Objective To explore the application of quality control circle ( QCC) on continuing nursing care among patients with high pressure sore risk. Methods A total of 218 patients, who discharged from hospital with high risk of getting pressure sore since July 2012 to December 2013 partly from the First People′s Hospital of Wujiang District and partly from community health center and nursing home, were equally divided into experimental group (110) and control group (108). The patients of experimental group treated with normal discharged education and traditional care while patients in the experimental group underwent the continuing nursing care. After 4 weeks discharged, it had been compared the knowledge and skill of pressure sore in caregivers, and the cure of pressure sore was observed at 8 weeks follow up after discharged. Results After 4 weeks QCC, the standard rate of knowledge and skill in caregivers was 90. 91% in the experimental group and 18. 52% in the control group (χ2 =115. 41,P<0. 01), while the occurrence rate of pressure sore was 6. 36%in the experimental group comparing with 29. 63% of the control group (χ2 =20. 08,P<0. 01). After 8 weeks QCC, the cured rate of pressure sore was 57. 14% of the experimental group compared with 12. 50% of the control group (χ2 =43. 111,P <0. 01). Conclusions Application of QCC on continuing nursing care can effectively reduce the incidence of pressure sore among patients at home and in community, as well as increase recovery rate. It is one of innovation for new medical arena.

Objective To explore the effects of simethicone on gastrointestinal hormones,intestinal floras and inflammatory process mediated by NOD-like receptor protein 3(NLRP3)inflammasome in patients with irritable bowel syndrome(IBS).Methods A total of 120 patients with IBS admitted to the hospital were prospectively enrolled as the research objects between January 1,2021 and December 31,2022,and they were randomly divided into control group(60 cases)and treatment group(60 cases).The control group was treated with compound eosinophil-Lactobacillus,while treatment group was additionally treated with simethicone.The curative effect after treatment,scores of gastrointestinal symptom rating scale(GSRS),levels of somatostatin(SS),vasoactive intestinal peptide(VIP),NLRP3 inflammasome,interleukin-8(IL-8)and interleukin-1β(IL-1β),counts of intestinal floras before and after treatment,and safety during treatment were compared between the two groups.Results After treatment,total response rate of treatment group was higher than that of control group(91.67% vs.76.67% ,P<0.05).After treatment,GSRS scores in both groups were decreased,which were lower in treatment group than control group(P<0.05).After treatment,levels of SS and VIP in both groups were decreased,which were lower in treatment group than control group(P<0.05).After treatment,counts of eosinophil-Lactobacillus and Bifidobacteria were increased in both groups,the difference was statistically significant(P<0.05),but there was no significant difference in counts of intestinal floras between the two groups(P>0.05).After treatment,levels of NLRP3 inflammasome,IL-8 and IL-1β were decreased in both groups,the difference was statistically significant(P<0.05),but there was no significant difference between the two groups(P>0.05).During treatment,there was no significant difference in side effects between the two groups(P>0.05).Conclusion Simethicone can significantly improve response rate of treatment,improve gastrointestinal symptoms and gastrointestinal hormones in IBS patients,which has no significant effects on intestinal floras and inflammatory process mediated by NLRP3 inflammasome,with good safety.

0.05 ). After once injection both observers considered the number of clearly recognized endocardial border segments increased significantly. The number evaluated by observers A increased from 2.68 ? 0.95 to 5.99 ? 0.10 while from 2.82 ? 1.03 to 5.99 ? 0.11 by observers B( P 0.05 ). The average contrast enhancement rate of LV endocardial border was 99.7 %. Perfluoropropane-albumin microsphere injection had no significant effection on vital signs such as blood prssure, heart rate and respiration. Electrocardiogram didn′t change markedly and the variance of the laboratory findings like blood and urine routine examination, hepatic and renal function was in normal range. Only one case( 0.33 %) had slight side-effects who suffered from mild nausea and diarrhea, which suggested the clinical safety of this contrast agent. Conclusions Perfluoropropane-albumin microsphere injection could enhance the resolution of LV endocardial borders and make the judgement of regional myocardial movement easier. It has little side-effects and will be appropriate for clinical use.