Objective To evaluate the efficacy and safety of DanHong injection in treatment of diabetic nephropathy.Methods 80 patients with diabetic nephropathy were selected and divided into two groups randomly after admission;40 cases for the observation group,received Danhong injection treatment ;40 cases as control group treated with losartan potassium tablets.Two treatment situations and adverse reactions were assessed after 4wk treatment.Results Effective rate in observation group was 50% significantly higher than that in control group of 27.5% (P<0.05,see Table 1);During treatment period both groups had no obvious adverse reactions,all patients can be tolerated.Conclusion Danhong injection for treatment of diabetic nephropathy was not only good,but also relatively safe.

Objective:To comparatively analyze the diagnostic value of patent foramen ovale and the degree of right-to-left shunt among the traditional Valsalva maneuver (VM), the modified Valsalva maneuver (mVM) and the compression of the inferior vena cava combined with modified Valsalva maneuver (CM).Methods:A total of 132 patients with migraine, dizziness, chest pain and other symptoms in Longgang District People′s Hospital of Shenzhen from January 2021 to December 2021 were prospectively enrolled. The detection rate of patent foramen ovale and the degree of right-to-left shunt were assessed among the rest state and after performing the auxiliary maneuvers including VM, mVM and CM respectively.Results:After performing the auxiliary maneuvers, the detection rate of patent foramen ovale was significantly increased (88.6% vs 59.8%) with statistical significance (χ 2=36.026, P<0.001). There was a significant difference in the degree of right-to-left shunt among the three auxiliary maneuvers (χ 2=25.581, P<0.001). CM was the most effective for the detection of the large right-to-left shunt, and the difference was statistically significant compared with VM and mVM ( P<0.001, P=0.002). Conclusions:Auxiliary maneuvers is crucial for the diagnosis of patent foramen ovale. Compared with VM and mVM, performing CM can further improve the detection rate of patent foramen ovale and increase the degree of right-to-left shunt.

Objective To investigate the potential effect of proteoglycan(PG) and glycosaminoglycan(GAG) on the bonding of etch and rinse adhesive to dentin,in order to improve the bonding effect of dentin.Methods Forty-two extracted molars were used to obtain standard dentin bonding surface,and the specimens were etched for 15 s with 37％ phosphoric acid and divided into three groups using a table of random numbers.Then the three groups undergone different incubating procedures as follow:specimens in chondroitinase ABC(C-ABC) group were incubated with C-ABC at 37 ℃ for 48 h in vibrator.Specimens in trypsin(TRY) group were incubated with trypsin,and specimens in the control group were incubated with deionized water for 48 h in the oscillators.Then specimens in each group were randomly assigned into two subgroups,A(AdperTM Single Bond 2) and B(Prime & Bond NT) (n=7).The microtensile bond strength(μTBS),fracture mode and bonding interface morphology of the specimens were evaluated via microtensile testing,stereo microscope and field emission scanning electron microscopy(FE-SEM) respectively after specimens being incubated in 37 ℃ water for 24 h.Results The immediate μTBS of C-ABC group bonding with adhesive A and B [(32.9±2.5) and (26.8±2.2) MPa] were significantly lower than that of the control group [(40.7±3.3) and (34.6±3.7) MPa](P＜0.05).While the immediate μTBS of TRY group [(49.0± 3.6) and (44.5± 3.0) MPa] were significantly higher than that of the control group(P＜0.05).Conclusions Dentin PG participates in the dentin bonding process.Removal of PG increased the immediate μTBS of dentin and total etching adhesives,while removal of GAG decreased the immediate μTBS.

Objective: To investigate the potential effect of proteoglycans (PG) and glycosaminoglycans (GAG) on the stability of resin-dentin bonds against artificial saliva storage. Methods: Seventy-two extracted molars were used to obtain standard dentin bonding surface, and the specimens were etched for 15 s with 37% phosphoric acid and divided into three groups using a table of random number. Then the three groups undergone different incubating procedures as follow: specimens in chondroitinase ABC (C-ABC) group were incubated with C-ABC, specimens in trypsin (TRY) group were incubated with trypsin, and specimens in the control group were incubated with deionized water. All specimens were incubated at 37 ℃ for 48 h in the oscillators. Then specimens in each group were randomly assigned into three subgroups (n=8) as follows: immediate control subgroup, aging subgroups with artificial saliva storage for 6 months and 12 months. Microtensile bond strength (μTBS), fracture mode, bonding interface morphology and nanoleakage were evaluated. Results: Immediately and with artificial saliva storage for 6 months and 12 mouths, the μTBS of TRY group ([49.04±3.57], [37.01±3.21] and [35.27±3.56] MPa) were significantly higher than those in the control group ([40.71±3.32], [28.87±2.34] and [24.20±2.07] MPa) (P<0.05). The immediate μTBS of C-ABC group ([32.94±2.45] MPa) was significantly lower than that of the control group (P<0.05). While with artificial saliva storage for 6 months and 12 mouths, the μTBS of C-ABC group ([26.46±2.45] and [22.50±2.58] MPa) were no differences with those of the control group (P>0.05). The ratio of cohesive fracture increased with the extension of aging time. Some narrow gaps were found in hybrid layer of the control group with artificial saliva storage for 6 months and 12 mouths. Conclusions Removal of PG increased the μTBS and durable bonds to dentin, while removal of GAG decreased the μTBS, however, it can be of help to create more durable bonds to dentin.