Objective To observe the clinical efficacy of bletilla striata gelantin (BSG) loaded exogenous high molecular weight (HMW) nerve growth factor (NGF) in the promotion of deep pressure sore healing. Methods The patients with deep pressure sore were randomly divided into four group: group A, as the control group, used iodophor-soaked sterile gauze for continuous wet compressing; group B, group C and group D, as the experiment group, received external application of BSG, HMW-NGF and HMW-NGF+BSG 3 times per day. The observation indicators included the pressure sore healing velocity, healing time, general reactions and local skin inflammatory reactions during medication on day 3, 7, 14, 21 and 30 of medication. Results BSG, HMW-NGF and HMW-NGF+BSG could all promote the wound healing of pressure sore and HMW-NGF+BSG has the most remarkable effect (healing days: A∶B∶C∶D=20.16 ± 4.58∶15.43±1.72∶15.80±1.48∶11.86±1.35d). Conclusion HMW-NGF+BSG can obviously accelerate the wound healing of pressure sore.