Objective To investigate surgical treatment and nursing of upper extremity arterial occlusive disease.Methods A total of 12 patients with upper extremity arterial occlusive disease from January 2001 to November 2014 in our hospital were treated by vascular transplantation. Patients received comprehensive preoperative examination,careful postoperative observation and specialist nursing.Nursing interventions were summarized with retrospective analysis.Results Patients after revascularization were followed up for 1 to 2 years.Graft vascular patency,hands ulcer healing and blood supply restoration were satisfied with effects.Conclusions The effects are satisfied after autologous vascular transplantation and artificial vascular transplantation work impressively on vascular reconstruction in patients with upper extremity arterial occlusive disease. Comprehensive preoperative examination, careful postoperative observation and nursing play an important role in the success of the surgery.