1.The distribution characteristics of monosomal karyotype in 123 elderly patients with acute myeloid leukemia
Hui LIU ; Lei PEI ; Shangyong NING ; Jiangtao LI ; Ru FENG
Chinese Journal of Geriatrics 2015;34(10):1091-1093
Objective To explore the distribution characteristics of monosomal karyotype (MK) in elderly patients with acute myeloid leukemia (AML).Methods The karyotype analysis was performed in 123 elderly patients with newly diagnosed AML in our center from Nov 2000 to Feb 2015.We retrospectively studied the distribution characteristics of monosomal karyotype in these patients.Results Among 123 elderly patients with AML,117 patients had enough metaphases chromosomes for analysis.Among the 117 patients,there were 16 cases with good-risk karyotype,54 cases with intermediate-risk karyotype,and 47 cases with adverse-risk karyotype.In the 47 patients with adverse-risk karyotype,43 cases had complex karyotypes (CK).In the 117 elderly AML patients,37 cases (31.6%) had monosomal karyotype (MK),22 AML cases were secondary to myelodysplastic syndrome (MDS-AML),among them 13 cases (55.0%) had MK.In the 95 cases with primary AML,the detection rate of MK was 25.3% (24 cases).The detection rate of MK+ AML was higher in MDS-AML patients than in de novo AML patients (P=0.000).Among the 37 patients with MK+AML,35 cases had complex karyotypes.30 (81.1%) MK+AML patients had two or more distinct autosomal monosomies and 7 (18.9%) MK+ AML patients had one single autosomal monosomy in the presence of structural abnormalities,and the incidence of autosomal monosomies was higher than that of single autosomal monosomy.The presence of--5 (27.0%),-4 (18.9%),-7 (16.3%) and-6 (13.5%) chromosomes was the most common autosomal monosomy among MK+ AML patients.Conclusions The detection rate of MK is relatively high in elderly AML patients.Two or more distinct autosomal monosomies are more common.The detection rate of MK+AML is higher in patients with MDS-AML than in patients with de novo AML.
2.Significance of COX2 and beta-catenin expression in nephroblastoma.
Xiao-Li HU ; Lin-Sheng ZHAO ; Lan-Yun SONG ; Pei-Ru NING
Chinese Journal of Pathology 2008;37(10):698-699
Child
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Child, Preschool
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Female
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Gene Expression Regulation, Neoplastic
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Humans
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Infant
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Male
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Wilms Tumor
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genetics
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metabolism
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Wnt Proteins
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genetics
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metabolism
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beta Catenin
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genetics
;
metabolism
3.Carcinoid tumor of common bile duct: report of a case in pediatric patient.
Lan-yun SONG ; Xiao-li HU ; Lin-sheng ZHAO ; Pei-ru NING
Chinese Journal of Pathology 2011;40(1):54-55
Adenocarcinoma
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metabolism
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pathology
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Carcinoid Tumor
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metabolism
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pathology
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surgery
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Child
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Chromogranin A
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metabolism
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Common Bile Duct
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pathology
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surgery
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Common Bile Duct Neoplasms
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metabolism
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pathology
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surgery
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Diagnosis, Differential
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Duodenum
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pathology
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surgery
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Gallbladder
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pathology
;
surgery
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Humans
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Keratins
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metabolism
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Lymphoma
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metabolism
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pathology
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Male
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Mucin-1
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metabolism
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Neoplasm Invasiveness
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Rhabdomyosarcoma
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metabolism
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pathology
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Stomach
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pathology
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surgery
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Synaptophysin
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metabolism
5.Epigastric heteropagus twins: report of a case.
Xiao-li HU ; Lan-yun SONG ; Lin-sheng ZHAO ; Pei-ru NING
Chinese Journal of Pathology 2009;38(7):491-492
Abnormalities, Multiple
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pathology
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surgery
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Humans
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Infant, Newborn
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Male
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Twins, Conjoined
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pathology
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surgery
6.Nephroblastomatosis and nephroblastoma: report of a case.
Xiao-li HU ; Lan-yun SONG ; Lin-sheng ZHAO ; Pei-ru NING ; Li ZHAO
Chinese Journal of Pathology 2013;42(12):841-842
Humans
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Infant
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Kidney Neoplasms
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metabolism
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pathology
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surgery
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Male
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Mucin-1
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metabolism
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Nephrectomy
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Precancerous Conditions
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metabolism
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pathology
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surgery
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Vimentin
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metabolism
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WT1 Proteins
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metabolism
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Wilms Tumor
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metabolism
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pathology
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surgery
9.Analysis of therapeutic effects and prognostic factors of autolo-gous peripheral stem-cell transplantation for 30 patients with mul-tiple myeloma
Ting WANG ; Hui LIU ; Jiangtao LI ; Ru FENG ; Yuan TIAN ; Baoli XING ; Xiaodong XU ; Lei PEI ; Shangyong NING
Chinese Journal of Clinical Oncology 2015;(1):24-27
Objective:To evaluate the clinical efficiency and prognostic factors of autologous peripheral blood stem cell trans-plantation (APBSCT) in 30 cases of multiple myeloma (MM). Methods:Two of the 30 patients received the second treatment of APB-SCT because of relapse after the first treatment. Thus, a total of 32 case-times of APBSCT were studied. Combination chemotherapy was inducted regularly before APBSCT (11 patients used bortezomib as an induction drug), and chemotherapy combined with the G-CSF regimen was used to mobilize peripheral blood stem cells. Preconditioning was based on melphalan. Results:Mononuclear cells in harvest were 6.41 × 108/kg, and CD34+cells in harvest were 4.75 × 106/kg. The median times of neutrophil and platelet engraftment were 9.5 and 11 d, respectively. The complete remission (CR) and very good partial remission (VGPR) rates were 37.5%and 34.4%af-ter APBSCT, respectively. The median overall survival (OS) was 67.27 months in all patients, and the median progression-free survival (PFS) was 29.77 months. The median PFS rates were 29 and 20 months in the patients who achieved CR and PR, respectively, and the median PFS was not observed in the patients who achieved VGPR. Statistical differences in PFS were detected between the CR+VGPR and PR groups (P=0.025). The CR rates were 63.6%and 23.8%in the bortezomib (bortezomib-based chemotherapy) and non-bortezo-mib groups (P=0.034), respectively. The median OS and PFS were not obtained in the bortezomib group, whereas the median PFS was 22 months in the non-bortezomib group (P=0.045). Conclusion: MM patients treated with bortezomib-based chemotherapy followed by APBSCT had prolonged PFS. APBSCT can improve the response and survival of MM patients.
10.The relationship between thrombin activatable fibrinolysis inhibitor and coronary heart disease
ZHAO Meng Nan ; TIAN Pei Ru ; QIU Li ; LI Yu Ning ; WANG Xiao Nan ; YI Bo Yu ; SHI Jing Pu
Journal of Preventive Medicine 2020;32(12):1208-1212
Objective:
To analyze the relationship between thrombin activatable fibrinolysis inhibitor ( TAFI ) and coronary heart disease ( CHD ), and to provide evidence for the prevention of CHD.
Methods:
The patients with CHD in Fushun Central Hospital in Liaoning Province were selected as the case group, the patients without CHD in the same hospital and period were selected as the control group. The demographic information and clinical examination results ( serum TAFI, lipid, glucose, etc. ) were collected to analyze the association between TAFI and CHD by logistic regression models.The multivariate logistic regression analysis was used to explore the relationship between TAFI and CHD.
Results:
There were 222 cases, including 100 cases of stable angina, 44 cases of unstable angina and 78 cases of acute myocardial infarction, and 222 controls. The median ages of cases and controls were 62 and 57 years old. The results of multivariate logistic regression analysis showed that serum TAFI>22.88 μg/mL ( P75 of controls ) was associated with the risk of CHD ( OR=1.619, 95%CI: 1.011-2.593 ), unstable angina ( OR=2.917, 95%CI: 1.433-5.939 ) and acute myocardial infarction ( OR=2.626, 95%CI: 1.007-6.847 ).
Conclusion
The high level of TAFI is related to CHD, unstable angina and acute myocardial infarction.