1.Progression of the mechanism study on experimental migraine treated with acupuncture in rat model.
Lu LIU ; Pei PEI ; Linpeng WANG
Chinese Acupuncture & Moxibustion 2016;36(3):331-336
In the paper, by taking acupuncture and migraine as the key words to retrieve CNKI and PubMed database, the literature analysis was done on the mechanism study on experimental migraine treated with acupuncture in rat model. The results showed that acupuncture mechanism study focused on the regulation and control of the relevant neurotransmitters/neuromodulators of migraine, such as calcitonin gene-related peptide (CGRP), serotonin (5-HT), nitric oxide (NO), etc. Moreover, in the paper, the review had been done on the neurotransmitters/neuromodulators involved in the study.
Acupuncture Points
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Acupuncture Therapy
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Animals
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Disease Models, Animal
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Humans
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Migraine Disorders
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genetics
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metabolism
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therapy
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Nitroglycerin
;
metabolism
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Rats
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Serotonin
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metabolism
3.Invasive urothelial carcinoma in bladder associated with bilateral benign ovarian Brenner tumor: report of a case.
Shan LU ; Fei PEI ; Song-lin LIAO
Chinese Journal of Pathology 2009;38(7):485-486
Aged
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Anion Exchange Protein 1, Erythrocyte
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metabolism
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Brenner Tumor
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metabolism
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pathology
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surgery
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Carcinoma, Transitional Cell
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metabolism
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pathology
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surgery
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Chromogranin A
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metabolism
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Cystectomy
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Female
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Humans
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Hysterectomy
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Membrane Proteins
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metabolism
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Neoplasms, Multiple Primary
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metabolism
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pathology
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surgery
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Ovarian Neoplasms
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metabolism
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pathology
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surgery
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Urinary Bladder Neoplasms
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metabolism
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pathology
;
surgery
4.Enhanced calcium release induced by tumor necrosis factor alpha in glomerular mesangial cells participated in hepatorenal syndrome
Journal of Chinese Physician 2013;(1):11-14
Objective To investigate the effect of tumor necrosis factor-α (TNF-α) on intracellular calcium concentration ([Ca2 +] i) and the contraction of glomerular mesangial cells (GMCs),and prove that hypercontractility of GMCs induced by TNF-α in hepatorenal syndrome(HRS) was connected with inositol 1,4,5-trisphophate receptors (IP3Rs).Methods GMCs were divided into TNF-α-treated 0 h,4h,and 24 h groups.Another 3 groups were blocked by 2-APB.The effect of TNF-α on [Ca2 +] i was identified and observed whether it could be blocked by 2-APB.Contraction of GMCs was determined by accessing the surface area of cells before and after contraction.Results TNF-α significantly increased ET-induced calcium release,in that we found higher [Ca2 +] i after stimulated by ET in TNF-α-treated 4 h group and 24 h group[4 h:(648.08 ±267.11) nmol/L; 24 h:(879.30 ±-260.29) nmol/L; 0 h:(619.93 ±258.94)nmol/L,F =5.486,4 h vs 0 h:P < 0.05 ; 24 h vs 0 h:P < 0.05 ;24 h vs 4 h:P > 0.05].This phenomenon can be totally blocked by 2-APB in all groups.The change in planar surface area in response to ET was slightly in control cells but significantly enhanced in TNF-α-treated cells [4 h:(2198 ± 340)μm2; 24h:(2260±553)μm2; 0 h:(2436±474)μm2,F =4.001,4 h vs0 h:P <0.05; 24 h vs0 h:P <0.05;24 h vs 4 h:P > 0.05].Conclusion TNF-α can enhance ET-induced sarcoplasmic reticulum Ca2 + release and increase the contractile responses of GMCs to ET,which is associated with IP3Rs.TNF-α is responsible for hyperconstractility of glomeruli in HRS.
5.The changes of barrier of gut in severe hepatitis
Dongyan LIU ; Xueheng LU ; Pei LIU
Clinical Medicine of China 2008;24(5):412-414
Objective To study the changes of IgA,secretory component(SC)and ZO-1,occludin of gut in severe hepatitis and to understand the reason of abdomen symptom in severe hepatitis patients.Methods IgA,SC,ZO-1 and occludin of gut were assayed by immunohistochemistry.Results Compared with the controls,the staining of IgA,SC,ZO-1 and occludin in severe hepatitis were notably decreased.Conclusion In severe hepatitis,IgA,SC,ZO-1 and occludin expression of gut decrease,leading to the abnormality of barrier of gut,which is one the reasons of resuhings in abdomen symptoms in severe hepatitis.
6.Drug Therapy for Vascular Dementia
International Journal of Cerebrovascular Diseases 2006;0(12):-
Various pathologic mechanisms and types of lesion have participated in cognitive impairment in patients with vascular dementia.A number of medications have been used in the treatment of patients with vascular dementia in clinical practice,including cholinesterase inhibitors, N-methy-D-aspartate receptor antagonists,calcium channel blockers and neurotrophic drugs. This article reviews the progress in research on the pharmacotherapy of vascular dementia.
7.Reflection on lemology teaching from the human infections with avian influenza A(H7N9)
Yuxia LU ; Changqing YANG ; Bei PEI
Chinese Journal of Medical Education Research 2013;(12):1235-1237,1238
The advent of human infections with avian influenza A(H7N9)and the emerging communicable disease has brought us profound thoughts on lemology teaching recently. We analyzed the exiting challenges of lemology teaching, including great changes in communicable diseases com-posing but limited class hours, decreasing of communicable diseases cases, medical students' psycho-logical apprehension, lack of teachers, more and more requirements in the prevention and treatment for communicable diseases from the public, etc. Several suggestions on how to further improve the lemology teaching quality were proposed including adjusting the curriculum arrangement, paing atten-tion to accumulate teaching cases, applying multi-media materials, taking full advantage of the teach-ing cases from specialized hospital, teaching students knowledge about themselves protection, improv-ing the quality of young teachers, emphasizing discipline characteristics and the importance of public health, reforming the teaching method and promoting the effect of teaching in communicable diseases.
8.The Construction and Development of Ethics Committee in Hospitals——From New Drug Research to the Ethical Management of Medical Treatment
Chinese Medical Ethics 1996;0(01):-
Ethics committee in hospitals aims to protect the rights of human subjects and patients,and provide ethical evaluation and justification for guaranteeing the quality of medical research and treatment.Based on experiences in recent years,this paper suggests the following methods in order to manage the activities of ethics committees and push its further development,such as to draft the ethics system,establish the criteria of ethics,implement the process administration and provide ethics training.
9.Association of serum and urine TWEAK with lupus nephritis activity and its underlying mechanism
Pei ZHANG ; Yonggui WU ; Min LU
Acta Universitatis Medicinalis Anhui 2015;(7):991-995
Objective To discuss the expression of tumor necrosis factor-like weak inducer of apoptosis ( TWEAK) in serum, urine and renal tissue in lupus nephritis( LN) . Methods The serum and urine levels of TWEAK were assessed by ELISA in LN patients and normal controls. Immunohistochemistry was used to detect the expressions of TWEAK in the kidney of patients and healthy controls. Results The serum and urine concentrations of TWEAK and MCP-1 were significantly higher in LN patients than those in healthy controls(P<0. 01). In addition,the level of serum TWEAK showed positive correlation with SLEDAI and negative correlation with serum C3 level ( P <0. 01),the expression of urine TWEAK showed positive correlation with SLEDAI (P<0. 05). In healthy renal tis-sues TWEAK was distributed mainly in renal tubules and rarely seen in glomerular while the expressions of TWEAK increased in renal tubular and glomeruli stainings were found in LN paitients. TWEAK could induce increased mac-rophage migration, may be involved in the pathological progression of lupus nephritis. Conclusion TWEAK may play key roles in the pathogenesis of LN. Meanwhile, TWEAK in serum and urine may be useful as markers of dis-ease activity. The change of TWEAK maybe associated with the pathology category of LN.
10.Neuroprotective effect of uric acid in ischemic stroke
Dandan LU ; Jing WANG ; Pei WANG
International Journal of Cerebrovascular Diseases 2015;23(7):546-549
Hyperuricemia is closely associated with hypertension,diabetes,coronary heart disease.However,numerous studies have shown that as a natural antioxidant,uric acid has a strong antioxidant effect.It can enhance the body's overall antioxidant capacity,scavenge free radicals in tissue,decrease the level of oxidative stress,and improve the outcomes in patients with stroke.It may provide a new target for the treatment of stroke through investigating the neuroprotective effect of uric acid on ischemic stroke.