Objective To investigate the application effect of comprehensive intervention on rehabilitation of schizophrenia patients in remission stage and residual period.Methods 300 patients with schizophrenia in the acute phase were divided into the observation group and the control group,the control group was given atypical antipsychotic drug treatment,the observation group was given mental health treatment based on the control group.Compliance,curative effects,side effects were compared between the two groups.234 patients were in remission and residual period were divided into comprehensive intervention treatment group and simple drug treatment group,quality of life,social function and cognitive function were compared between two groups.Results The total effective rate and compliance rate in the observation group were significantly higher than those of the control group(x2 =3.78,3.15,all P ＜ 0.05).Side effects scale(TESS) score in the observation group was significantly lower than that in the control group(t =2.58,P ＜ 0.05).In the remission phase and residual phase,the score of life quality,cognitive function score in comprehensive intervention group were significantly higher than those in the control group,the social function defect score was significantly lower than that in the control group(t =8.97,2.27,all P ＜ 0.05).Conclusion Comprehensive intervention is beneficial to reduce social function defects of schizophrenia patients,improve the therapeutic effect,and promote the recovery of cognitive function and quality of life.

ObjectiveTo investigate the delayed umbilical cord clamping in preterm children of anemia in premature children.Methods60 preterm children were randomly divided into study group and control group 30 patients in each group.The control group was taken regular off umbilical,the observation group delay 90s(after birth at least 2min) off umbilical.ResultsThe Hb, HCT, and SI in the postnatal 1,2,4,8 weeks were significantly lower than the observation group, the difference was statistically significant (all P ＜ 0.05), and the control group after birth in preterm children Ret in the first week was significantly higher than 2,4 in the observation group, the difference was statistically significant(all P ＜ 0.05) ; The observation group at 6 months the incidence of anemia(13.3％) and transfusion rate(6.7％) were significantly lower than the control group(43.3％ ,33.3％) ,the difference was statistically significant(all P ＜0.01).ConclusionDelyed umbilical cord clamping in preterm children could increase the redblood cells and iron reserves in preterm children, reduce the incidence of anemia caused by blood transfusion, was worthy of clinical application.

Objective To study the clinical effect of diazepam and phenobarbital in children with febrile convulsion.Methods Seventy cases of febrile convulsion patients were divided into control group (phenobarbital treatment,35 cases) and experiment group (diazepam combined with phenobarbital,35 cases) by random digits table method,and compared the efficacy and complications.Results Two groups were cured within 1 h.The effective rate within 30 min in experiment group was significantly higher than that in control group [88.6％ (31/35) vs.74.3％ (26/35)] (P ＜ 0.05).The recurrent rate in experiment group was significantly lower than that in control group [2.9％ (1/35) vs.14.3％ (5/35)] (P ＜ 0.05).The complications had no statistically significant differences between two groups(P ＞ 0.05).Conclusions Diazepam combined with phenobarbital are very effective for children with febrile convulsion,can greatly improve clinical efficacy,decrease recurrent rate,and won't produce adverse reaction and complications,are the ideal treatment in the clinical treatment.

Objective To discuss the curative effect of small incision thyroidectomy on thyroid nodule . Methods 94 patients with thyroid nodule were selected and divided into the small incision group and control group according to different modes of operation ,47 cases in each group .The patients in small incision group were given small incision thyroidectomy ,while the patients in control group were given the traditional big incision thyroidectomy .The curative effect and security in the two groups were observed and compared .Results The operation time,intraoperative amount of bleeding ,length of incision and length of hospital stay in the small incision group were (48.76 ±10.37) min, (39.57 ±7.68)mL,(3.57 ±0.68)cm(4.89 ±1.13)d,which were significantly less than those in the control group [(54.07 ±11.64)min,(64.16 ±7.98)mL,(6.88 ±0.65)cm,(5.47 ±1.32)d](t=2.13,3.12,3.96,2.14,P<0.05 or P<0.01).The incidence rate of adverse reactions in small incision group was 10.6%,which was significant-ly lower than 29.8%in control group (χ2 =5.34,P<0.05).Conclusion Compared with traditional mode of opera-tion,small incision thyroidectomy has following advantages on thyroid nodule ,smaller operation wound ,less intraopera-tive amount of bleeding ,quicker postoperative recovery ,better cosmetic effect ,less adverse reactions ,etc.

OBJECTIVE:To observe the efficacy and safety of methylprednisolone combined with entecavir in the treatment of primary nephrotic syndrome with hepatitis B virus infection. METHODS:23 primary nephrotic syndrome patients with hepatitis B virus infection were given 0.5 mg/times Entecavir tablet,orally,once a day,for 2 weeks,and added 0.8mg/(kg.d)Methylpredniso-lone tablet,orally,once a day,for 8 weeks,then the dose was maintained for 2-3 months every other day,and then decreased 4 mg for 4 weeks every other day,and the dose was decreased 4 mg every 2-4 weeks,until drug withdrawal. Entecavir tablet was used in the whole process of Methylprednisolone tablet,the dose was adjusted and gradually stopped based on HBV-DNA within 3 months of Entecavir tablet withdrawal. Liver and renal efficacy,24 h urine protein excretion,serum albumin(ALB),alanine ami-notransferase(ALT),aspartate aminotransferase(AST)levels before and after treatment of 2,6,12 and 15 months,and the inci-dence of adverse reactions of all patients were observed. RESULTS:The liver and renal efficacy were 100%;after treatment of 2, 6,12 and 15 months,24 h urine protein,ALT and AST were significantly lower than before and gradually decreased by time, ALB was significantly higher than before and gradually increased by time,the differences were statistically significant(P<0.05);the incidence of adverse reactions was 43.48%,and there were no obvious adverse reactions and no renal dysfunction. CONCLU-SIONS:Methylprednisolone combined with entecavir has significant efficacy in the treatment of primary nephrotic syndrome with hepatitis B virus infection,with good safety.

The author's retinoscopy with a double-door type of illumination is presented in this paper. It is an objective method for the measurement of refractive errors by using an elect ic retinoscope. Spherical lens are used to neutralize the illumination from the pupil of the Patient u til the size, intensity and rapidity of movement of the double-door illumination from the pupil becomes almost identical. When a lineal back slit srace has been revealed in the middle of the double-door illumination, with a point of re(?)lex light on the center corneal surface, the neutral point is determined. The main points of using this method are also discussed in this paper.

In the present experiment, we investigated the im munoprophylactic and immunotherapeutic effects of transferring spleen LAK cells or " LAK-88/DC " cells from 615 inbred mice against mouse leukemia. The results showed that transferring LAK cells or "LAK-88/DC" cells and injecting conditional medium for a week 21 days before L615 inoculation induced significant prophylactic effects, which cured 80% of the L615-sufferring mice. Injecting conditional medium alone was also effective, which cured 60% of the mice, While transferring LAK cells or "LAK-88/DC" cells at the same time with L615 inoculation or 1 day after L615 inoculation presented no apparent therapeutic effect. However, when combined with cyclophosphamide (CY) chemotherapy, the transfer of LAK cells or "LAK-88/DC " cells 5 days after L615 inoculation could prolong the mean survival time and even cured 25%-28.6% of the advanced L615 leukemic mice.

Several photosensitive materials of Chinese make have been used for the whole- body autoradiography of the tritium labelled and freeze-drid sections of mice.1 mCi of tritiated water was injected peritoneally into each mouse.Sections prepared from the mouse were placed in direct contact with fast X-ray films for ihdustrial use,made in Tianjin.After 22 days of exposure,satisfactory autoradiographs were obtained.When the X-ray film for medical use,made in Shanghai,was tried,no satisfactory autoradi- ograph was obtained after 30 days of exposure.Besides,the dry plate prepared in our laboratory from Nuclear Emulsion №4.has also been tried,but only an incomplete outline was seen on the autoradiograph even after 124 days of exposure.

Bone tissue engineering is the focus of recent research. Its status quo and tendency are discussed from scaffold, cell and tissue reconstruction. Based on this analysis, we want to shorten the distance before it's clinical application and give some reasonable methods.

High myopia is a complicated disease as it resembles with primary open-angle glaucoma(POAG)in appearance of the fundus.To avoid making mistake,we would think much of similarities and differences between them.Modern equipments give large number of informations about the fundus,which predominate to establish the quantitative analysis when following up other than early diagnosis.Visual field analysis is interfered by HM fundus dystrophy,also relationship with study curve,long wave motion and short wave motion.It is very important in diagnosis and differential diagnosis with routine methods in clinical work.The experience and judgment of the doctors are never replaced by equipment as yet.