Objective To investigate the application effect of comprehensive intervention on rehabilitation of schizophrenia patients in remission stage and residual period.Methods 300 patients with schizophrenia in the acute phase were divided into the observation group and the control group,the control group was given atypical antipsychotic drug treatment,the observation group was given mental health treatment based on the control group.Compliance,curative effects,side effects were compared between the two groups.234 patients were in remission and residual period were divided into comprehensive intervention treatment group and simple drug treatment group,quality of life,social function and cognitive function were compared between two groups.Results The total effective rate and compliance rate in the observation group were significantly higher than those of the control group(x2 =3.78,3.15,all P ＜ 0.05).Side effects scale(TESS) score in the observation group was significantly lower than that in the control group(t =2.58,P ＜ 0.05).In the remission phase and residual phase,the score of life quality,cognitive function score in comprehensive intervention group were significantly higher than those in the control group,the social function defect score was significantly lower than that in the control group(t =8.97,2.27,all P ＜ 0.05).Conclusion Comprehensive intervention is beneficial to reduce social function defects of schizophrenia patients,improve the therapeutic effect,and promote the recovery of cognitive function and quality of life.

Objective To explore the outcomes of radiotherapy and zoledronic acid in patients with bone metastasis.Methods 48 cancer patients with bone metastasis,were divided into two group,control group received radiotherapy only,therapy group received radiotherapy and zoledronic acid.Remission of ostalgia was evaluated after 3-6 months.Results The total effective of remission of ostalgia had no significant differences between two group(83.3 ％ vs 79.2％,P ＜ 0.05).But rate of complete remission therapy group was higher than that of control group(50.0％ vs 33.3％,P ＜ 0.05).The adverse reaction aer resemble between the two group.Conclusion The outcomes of radiotherapy and zoledronic acid in patients with bone metastasis is effectiveness for cases with bone metastasis,is worth spreading.

Objective To investigate the clinical effects of different dose of remifentanil with double-tube type laryngeal mask airway (LMA) ventilation in the aged patients undergoing total hip-arthroplasty (THA).Methods Sixty ASA class Ⅰ-Ⅱ grade patients undergoing THA were enrolled in the study.The patients were divided into three groups according to remifentanil dose with 20 cases each,0.2 μ g/ (kg· min)group,0.3 μ g/(kg· min) group and 0.4 μ g/(kg· min) group.Heart rate and mean arterial pressure (MAP)were measured immediately before anesthesia induction,immediately after anesthesia induction,immediately after inserting LMA,the set of operation,15 min during operation and discontinuation of anesthetic.Results All patients were successfully operated without intraoperative awareness.In 0.2 μ g/(kg·min) group,the patients suffered from the heart rate and MAP fluctuations,the high incidence of body movement (45.0％,9/20),and the maximum amount of propofol [(82.4 ± 21.6) mg].In 0.3 μg/(kg· min) group,heart rate and MAP had the better fluctuation,and patients might wake up faster postoperatively.In 0.4 μ g/(kg· min) group,heart rate and MAP significantly decreased,the amount of efedrina [(5.2 ± 4.3) mg] was the largest in the three groups,the recovery time [(5.2 ± 1.3) min] was the longest Conclusion Remifentanil 0.3 μg/(kg·min) compound with propofol with double-tube type LMA can be used for total intravenous anesthesia in the elderly patients with THA,with hemodynamic stability,fewer complications,and reliable ventilation.

Objective To study the clinical effect of diazepam and phenobarbital in children with febrile convulsion.Methods Seventy cases of febrile convulsion patients were divided into control group (phenobarbital treatment,35 cases) and experiment group (diazepam combined with phenobarbital,35 cases) by random digits table method,and compared the efficacy and complications.Results Two groups were cured within 1 h.The effective rate within 30 min in experiment group was significantly higher than that in control group [88.6％ (31/35) vs.74.3％ (26/35)] (P ＜ 0.05).The recurrent rate in experiment group was significantly lower than that in control group [2.9％ (1/35) vs.14.3％ (5/35)] (P ＜ 0.05).The complications had no statistically significant differences between two groups(P ＞ 0.05).Conclusions Diazepam combined with phenobarbital are very effective for children with febrile convulsion,can greatly improve clinical efficacy,decrease recurrent rate,and won't produce adverse reaction and complications,are the ideal treatment in the clinical treatment.

Carcinoma in Situ ; metabolism ; pathology ; Carcinoma, Endometrioid ; metabolism ; pathology ; Cystadenocarcinoma, Serous ; metabolism ; pathology ; Endometrial Neoplasms ; metabolism ; pathology ; Female ; Humans ; Tumor Suppressor Protein p53 ; metabolism

Objective To analyze the detection results of blood fat and proinsulin related indicators in the patients with type 2 diabetes mellitus(T2DM ) and to investigate the means for improving the patients′ clinical indicators .Methods 57 patients with T2DM in our hospital from February 2013 to February 2015 were divided into the research group ( ≥ 15 .6 mIU /L ,29 cases) and the control group (< 15 .6 mIU /L ,28 cases) according to the proinsulin level .All the cases took glucose ,at the same time the cor‐relation between the blood fat indexes with serum true insulin ,proinsulin and insulin resistance index of steady state insulin assess‐ment model was analyzed .Results Proinsulin ,serum true insulin ,2 h postprandial proinsulin ,2 h postprandial serum true insulin , insulin resistance index of steady state insulin assessment model all had correlation with and apolipoprotein B /apolipoprotein A1 . Conclusion The proinsulin level in the patients with T 2DM is increased ,thus the ratio of apolipoprotein B/apolipoprotein A1 will be accordingly increased .

Lipoxins possess a wide spectrum of adjustment function for various inflammatory cell functioning and the expression of inflammatory related genes,also progressing the inflammatory response by means of various cell.Lipoxins play an important role in the pathogenesis and clinical treatment of kidney diseases.

OBJECTIVE:To observe the efficacy and safety of methylprednisolone combined with entecavir in the treatment of primary nephrotic syndrome with hepatitis B virus infection. METHODS:23 primary nephrotic syndrome patients with hepatitis B virus infection were given 0.5 mg/times Entecavir tablet,orally,once a day,for 2 weeks,and added 0.8mg/(kg.d)Methylpredniso-lone tablet,orally,once a day,for 8 weeks,then the dose was maintained for 2-3 months every other day,and then decreased 4 mg for 4 weeks every other day,and the dose was decreased 4 mg every 2-4 weeks,until drug withdrawal. Entecavir tablet was used in the whole process of Methylprednisolone tablet,the dose was adjusted and gradually stopped based on HBV-DNA within 3 months of Entecavir tablet withdrawal. Liver and renal efficacy,24 h urine protein excretion,serum albumin(ALB),alanine ami-notransferase(ALT),aspartate aminotransferase(AST)levels before and after treatment of 2,6,12 and 15 months,and the inci-dence of adverse reactions of all patients were observed. RESULTS:The liver and renal efficacy were 100%;after treatment of 2, 6,12 and 15 months,24 h urine protein,ALT and AST were significantly lower than before and gradually decreased by time, ALB was significantly higher than before and gradually increased by time,the differences were statistically significant(P<0.05);the incidence of adverse reactions was 43.48%,and there were no obvious adverse reactions and no renal dysfunction. CONCLU-SIONS:Methylprednisolone combined with entecavir has significant efficacy in the treatment of primary nephrotic syndrome with hepatitis B virus infection,with good safety.