1.The effect of sulodexide on the incidence of cardiovascular outcomes in patients with vascular disorders.
Eugenio B. REYES ; Paula Victoria Catherine Y. CHENG-BROMEO ; Nigel Jeronimo C. SANTOS
Philippine Journal of Cardiology 2025;53(1):87-97
BACKGROUND AND OBJECTIVES
Among patients with macrovascular and microvascular disease, we investigated the association between sulodexide and cardiovascular (CV) outcomes and adverse events.
METHODSWe conducted a meta-analysis of randomized control trials (RCTs) reporting CV outcomes and adverse events in patients with vascular disease receiving sulodexide for any indication versus control. The following outcomes were investigated: any CV event, myocardial infarction, CV death, bleeding events and gastrointestinal symptoms.
RESULTSTwelve studies with a total of 8,436 patients were included. Sulodexide resulted in a significant reduction in CV events (OR 0.51 [95% confidence interval 0.41-0.73]; pCONCLUSION
Sulodexide has a beneficial effect among patients with macrovascular disease in terms of reducing the risk for MI, overall CV mortality and CV events. Larger RCTs are needed to corroborate these findings.
Human ; Sulodexide ; Glucuronyl Glucosamine Glycan Sulfate
2.Depression and anxiety in adult cardiology patients consulting through telemedicine during the COVID-19 pandemic using the validated Filipino version of the hospital anxiety and depression score (Hads-P).
Paula Victoria Catherine CHENG-BROMEO ; Jeffrey VALENCIA ; Michael Vic BELUSO ; Felix Eduardo PUNZALAN
Philippine Journal of Cardiology 2025;53(1):32-39
BACKGROUND AND OBJECTIVES
Depression and anxiety are common among patients with cardiovascular disease. With increased stress from the ongoing pandemic, it is important to evaluate these conditions. Hence, this study aimed to identify the prevalence of depression and anxiety among outpatient consults via telemedicine through the HADS-P questionnaire and to compare the clinical and socioeconomic profile of patients with HADS-P score of >/=11.
METHODSThis is a cross-sectional descriptive study including participants, outpatients in the cardiology clinic through an online survey regarding their socioeconomic demographic profile and the HADS-P questionnaire. Patients with scores of >/=11 for anxiety or depression were identified and the two groups were compared using a chi-square test analysis.
RESULTSOne hundred and twelve patients were recruited. Majority were females, with a partner, unemployed and living below the poverty line. The most common cardiovascular condition was ischemic heart disease and most patients were at least functional class II. The measured prevalence of probable anxiety and depression were 22% and 8%, respectively. A significant difference between the presence of both anxiety and depression was seen in participants with no partners; and for depression alone, in employed participants.
CONCLUSIONAnxiety and depression are common in this sample population. HADS-P is a simple way of screening patients for these conditions so that holistic care may be instituted and appropriate referrals for psychological intervention may be done.
Human ; Anxiety ; Depression ; Telemedicine