1.Risk factors for recurrence amongst high intermediate risk patients with endometrioid adenocarcinoma.
Agnes Y BAHNG ; Christina CHU ; Paul WILEYTO ; Stephen RUBIN ; Lilie L LIN
Journal of Gynecologic Oncology 2012;23(4):257-264
OBJECTIVE: To determine risk factors associated with recurrence in patients with high intermediate risk (HIR) endometrioid adenocarcinoma. METHODS: A retrospective analysis of patients with HIR endometrioid adenocarcinoma who underwent hysterectomy, bilateral salpingo-oophorectomy, with or without pelvic/para-aortic lymphadenectomy at the University of Pennsylvania between 1990 and 2009 was performed. RESULTS: A total of 103 women with HIR endometrial cancer were identified. Multivariable analysis revealed that > or =2/3 myometrial invasion (HR, 4.79; p=0.010) and grade 3 disease (HR, 3.04; p=0.045) were independently predictive of distant metastases. The 5-year distant metastases free survival (DMFS) for patients with neither or one of these risk factors was 89%, and the 5-year DMFS for patients with both risk factors was 48% (p<0.001). CONCLUSION: Patients with both grade 3 disease and deep third myometrial invasion have a high risk of distant metastases. Identifying these patients may be important in rationally selecting patients for systemic therapy.
Carcinoma, Endometrioid
;
Endometrial Neoplasms
;
Female
;
Humans
;
Hysterectomy
;
Lymph Node Excision
;
Neoplasm Metastasis
;
Pennsylvania
;
Recurrence
;
Retrospective Studies
;
Risk Factors
2.Risk factors for recurrence amongst high intermediate risk patients with endometrioid adenocarcinoma.
Agnes Y BAHNG ; Christina CHU ; Paul WILEYTO ; Stephen RUBIN ; Lilie L LIN
Journal of Gynecologic Oncology 2012;23(4):257-264
OBJECTIVE: To determine risk factors associated with recurrence in patients with high intermediate risk (HIR) endometrioid adenocarcinoma. METHODS: A retrospective analysis of patients with HIR endometrioid adenocarcinoma who underwent hysterectomy, bilateral salpingo-oophorectomy, with or without pelvic/para-aortic lymphadenectomy at the University of Pennsylvania between 1990 and 2009 was performed. RESULTS: A total of 103 women with HIR endometrial cancer were identified. Multivariable analysis revealed that > or =2/3 myometrial invasion (HR, 4.79; p=0.010) and grade 3 disease (HR, 3.04; p=0.045) were independently predictive of distant metastases. The 5-year distant metastases free survival (DMFS) for patients with neither or one of these risk factors was 89%, and the 5-year DMFS for patients with both risk factors was 48% (p<0.001). CONCLUSION: Patients with both grade 3 disease and deep third myometrial invasion have a high risk of distant metastases. Identifying these patients may be important in rationally selecting patients for systemic therapy.
Carcinoma, Endometrioid
;
Endometrial Neoplasms
;
Female
;
Humans
;
Hysterectomy
;
Lymph Node Excision
;
Neoplasm Metastasis
;
Pennsylvania
;
Recurrence
;
Retrospective Studies
;
Risk Factors
4.BNT162B2 COVID-19 mRNA vaccination did not promote substantial anti-syncytin-1 antibody production nor mRNA transfer to breast milk in an exploratory pilot study.
Citra N Z MATTAR ; Winston KOH ; Yiqi SEOW ; Shawn HOON ; Aparna VENKATESH ; Pradip DASHRAATH ; Li Min LIM ; Judith ONG ; Rachel LEE ; Nuryanti JOHANA ; Julie S L YEO ; David CHONG ; Lay Kok TAN ; Jerry K Y CHAN ; Mahesh CHOOLANI ; Paul Anantharajah TAMBYAH
Annals of the Academy of Medicine, Singapore 2022;51(5):309-312
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