Methods: Radiograms of 1,496 patients (555 males and 941 females) from the first to 9th decade were examined for this study. Sagittal and coronal alignment, disc space narrowing, spur formation including diffuse idiopathic spinal hyperostosis (DISH), spondylolisthesis, and ballooned discs associated with biconcave bodies due to osteoporosis were among the parameters of lumbar spine morphologies examined on high-quality radiographs by both human observers and computers. Results: The alignment of the lumbar spine altered after birth and set at growth maturity, and then the curve was maintained till the end of the 5th decade afterward and the curve gradually hypolordotic. There were three types of coronal alignment abnormalities can be seen: idiopathic, osteopathic, and discogenic (degenerative lumbar scoliosis [DLS]). DLS developed after 6th decade. There was no scoliosis associated with spondylolysis or the post-laminofacetectomy period. Disc space narrowing and corporal spur formation were not seen till the end of 3rd decade comparatively speaking, the corporal spurs generated in the non-scoliotic spine were smaller than those in the scoliotic spine. DISH began to appear in the 5th-decade patients and its incidences increased gradually afterward. Porosis-related vertebral body collapse started to happen after 6th decade. There are three different types of spondylolisthesis: anterior, posterior, and lateral. The lateral slip occurred only in the scoliotic spine. All types were related to degenerative discs. Conclusions It has been shown that the morphology of the lumbar spine changes throughout time.

Rlsacea is chronic disease of the eye and facial skin, which is common in Caucasian. Ocular rosacea is often difficult for ophthalmologists to diagnose, especially when skin manifestations are not evident yet. Early diagnosis and early treatment is important to prevent its serious complications including corneal opacity and corneal perforation. A case of ocular rosacea in a 52-year-old Korean lady is reported. The patient was presented with hyperemic conjunctiva and vascularization, infiltration and thinning of the peripheral cornea. She did not have any specific skin lesion. But 20 years ago, she had suffered from rosacea. After administation of oral tetracycline and topicale and topical corticosteroid, the signs and symptoms of the ocular rosacea was markedly improved.
Chronic Disease ; Conjunctiva ; Cornea ; Corneal Opacity ; Corneal Perforation ; Early Diagnosis ; Humans ; Middle Aged ; Rosacea* ; Skin ; Skin Manifestations ; Tetracycline*

Rlsacea is chronic disease of the eye and facial skin, which is common in Caucasian. Ocular rosacea is often difficult for ophthalmologists to diagnose, especially when skin manifestations are not evident yet. Early diagnosis and early treatment is important to prevent its serious complications including corneal opacity and corneal perforation. A case of ocular rosacea in a 52-year-old Korean lady is reported. The patient was presented with hyperemic conjunctiva and vascularization, infiltration and thinning of the peripheral cornea. She did not have any specific skin lesion. But 20 years ago, she had suffered from rosacea. After administation of oral tetracycline and topicale and topical corticosteroid, the signs and symptoms of the ocular rosacea was markedly improved.
Chronic Disease ; Conjunctiva ; Cornea ; Corneal Opacity ; Corneal Perforation ; Early Diagnosis ; Humans ; Middle Aged ; Rosacea* ; Skin ; Skin Manifestations ; Tetracycline*

We evaluated the clinical results of phacoemulsification and posterior chamber lens implantation in posttrabeculectomy eyes. 26 eyes operated during Jan. 1990 to Dec.1995 were evaluated retrospectively with preoperative and postoperative visual acuity, intraocular pressure(IOP) and antiglaucomatous agent usage.The cataract operations were done by clear corneal incisions avoiding the filtering bleb sites. The average interval between trabeculectomy and cataract surgery was 25 months. From a total of 26 eyes 11 had the diagnosis of primary open angle glaucoma(POAG) and 12 eyes chronic angle closure glaucoma(CACG). The preoperative visual acuity was 0.3 or less in 53.8%, and the postoperative visual acuity was 0.4 or better in 57.7%. The preoperative and postoperative IOPs were 14.4+/-4.3mmHg and 15.3+/-4.6mmHg respectively, showing a slight increase. Filtering bleb failure was observed in one eye in which trabeculectomy was formed twice. Antiglaucomatous agent usage decreased to 8 cases from an initial 10 cases. The preoperative IOP of the 8 cases was 17.3+/-5.1mmHg, while it was 13.1+/-3.3mmHg in the 18 cases in which the IOP was controlled without treatment. There was a significant difference between the two(P=0.03). There was a significant relationship between preoperative and postoperative antiglaucomatous agent usage(P=0.01). Taken individually, POAG showed a greater incidence of postoperative antiglaucomatous agent usage than CACG, but was insignificant(P=0.56).
Blister ; Cataract ; Diagnosis ; Incidence ; Phacoemulsification ; Retrospective Studies ; Trabeculectomy ; Visual Acuity

BACKGROUND/AIMS: Smooth muscle cells (SMCs) characteristically express serum response factor (SRF), which regulates their development. The role of SRF in SMC plasticity in the pathophysiological conditions of gastrointestinal (GI) tract is less characterized. METHODS: We generated SMC-specific Srf knockout mice and characterized the prenatally lethal phenotype using ultrasound biomicroscopy and histological analysis. We used small bowel partial obstruction surgeries and primary cell culture using cell-specific enhanced green fluorescent protein (EGFP) mouse lines to study phenotypic and molecular changes of SMCs by immunofluorescence, Western blotting, and quantitative polymerase chain reaction. Finally we examined SRF change in human rectal prolapse tissue by immunofluorescence. RESULTS: Congenital SMC-specific Srf knockout mice died before birth and displayed severe GI and cardiac defects. Partial obstruction resulted in an overall increase in SRF protein expression. However, individual SMCs appeared to gradually lose SRF in the hypertrophic muscle. Cells expressing low levels of SRF also expressed low levels of platelet-derived growth factor receptor alpha (PDGFRalphalow) and Ki67. SMCs grown in culture recaptured the phenotypic switch from differentiated SMCs to proliferative PDGFRalphalow cells. The immediate and dramatic reduction of Srf and Myh11 mRNA expression confirmed the phenotypic change. Human rectal prolapse tissue also demonstrated significant loss of SRF expression. CONCLUSIONS: SRF expression in SMCs is essential for prenatal development of the GI tract and heart. Following partial obstruction, SMCs down-regulate SRF to transition into proliferative PDGFRalphalow cells that may represent a phenotype responsible for their plasticity. These findings demonstrate that SRF also plays a critical role in the remodeling process following GI injury.
Animals ; Blotting, Western ; Fluorescent Antibody Technique ; Gastrointestinal Tract ; Heart ; Humans ; Mice ; Mice, Knockout ; Microscopy, Acoustic ; Muscle Cells ; Muscle, Smooth* ; Myocytes, Smooth Muscle ; Parturition ; Phenotype* ; Plastics ; Polymerase Chain Reaction ; Primary Cell Culture ; Receptors, Platelet-Derived Growth Factor ; Rectal Prolapse ; RNA, Messenger ; Serum Response Factor*