Aged ; Faculty ; Female ; Humans ; Middle Aged ; Pneumoconiosis

Aged ; Aged, 80 and over ; Coal Mining ; Humans ; Male ; Middle Aged ; Pneumoconiosis ; complications ; epidemiology ; Tuberculosis, Pulmonary ; complications ; epidemiology

Objective: To study the expressions of nm23 and CD44v6 proteins in non-small cell lung cancer (NSCLC) and their clinical significance. Methods: Expressions of nm23 and CD44v6 proteins were detected in 58 cases with NSCLC by two-step immunohistochemistry. Results: The overall positive rate of nm23 staining was 87.9% (51/58). There was a significant difference between T1-T2 group and T3-T4 group (P < 0.05). The overall positive rate of CD44v6 was 55.2% (32/58). It was significantly higher in squamous cell carcinoma than that in adenocarcinoma (85.7% vs 24%, P < 0.05) and significantly higher in moderate differentiated group than that in poor- and well-differentiated group (71.9% vs 44.4% and 35.3%, P < 0.05). The expressions of nm23 and CD44v6 were not associated with pTNM stage, lymph node metastasis, and survival rate (P > 0.05). Conclusion: The expressions of nm23 and CD44v6 correlated with the tumor size, pathological classification, differentiation degree of NSCLC but had no relation with pTNM stage and lymphnode metastasis.

Objective To analyze the characteristics of Han and Uygur patients with acute myocardial infarction (AMI)of coronary artery disease and its risk factors in Kashi area.Methods The clinical data of 98 cases of Han and Uygur 152 cases with AMI (including acute ST segment elevation myocardial infarction and acute non ST segment elevation myocardial infarction)were retrospectively analyzed.And risk factors were analyzed.Results Uygur patients with AMI in hypertension,diabetes,smoking,obesity and Han patients with no significant difference(P >0.05).In Uygur patients with AMI high density lipoprotein cholesterol(HDL -C)was (1.10 ±0.36)mmol/L,which was lower than Han patients (1.41 ±0.53)mmol/L(t =6.701,P <0.05),triglyceride(TG)[(2.21 ±1.40)mmol/L] higher than Han patients[(1.76 ±0.77)mmol/L](t =6.393,P <0.05),total cholesterol and low density lipoprotein cholesterol and Han patients compared with no significant difference(P >0.05).The level of fibrinogen(FIB)in Uygur AMI patients[(4.02 ±0.84)g/L]was higher than that in Han patients[(3.69 ±0.69)g/L](t =8.420,P =0.004).Uygur patients with acute myocardial infarction coronary angiography showed multiple lesions in the majority, the involvement of blood vessels in the anterior descending branch,there was no significant difference between the Han patients(P =0.713).No obvious abnormal vessels of Han and Uygur AMI patients in coronary angiography showed no statistically significant differences(P =0.003).Conclusion Uygur patients had more history of dyslipidemia,triglyceride and fibrinogen levels were higher than the Han nationality,low density lipoprotein levels were lower than that of the Han nationality.Patients with no obvious lesion in the coronary artery were less than the Han patients.

OBJECTIVETo analyse CT and high resolution computerized tomography (HRCT) diagnostic value and morphologic manifestation in coal miner's pneumoconiosis with pleural pathological changes.

METHODSOne hundred and thirty-one cases of coal miner patients with pneumoconiosis (0(+) type: 14 cases, type I: 46 cases, type II: 58 cases, type III: 13 cases) and 20 normal people as control group were first examined by routine CT scan at 4 fixed slices, followed by HRCT examination at the region of interest (ROI). Meanwhile, all of them had high-kV chest radiography.

RESULTSAccording to the national standard of the People's Republic of China in the diagnosis of coal miner's pneumoconiosis with pleural plaque, 68 cases of pleural disease making up 51.91% (68/131) were found (type I accounted for 17.65%, type II 63.24%, type III 19.12%). The morphologic manifestation of pleural pathology by HRCT could be classified into four types: (1) nodular type: 73.38%, (2) flat type: 18.71%, (3) irregular type: 7.91%, (4) mixed type. The pleural pathological changes were found in thoracic wall pleura (65.02%), surface of mediastinum (22.16%), and pericardium (12.80%), but not found in the top of lung and costo-phrenic angles. The thickness of pleura was often about 5 approximately 10 mm (88.17%).

CONCLUSIONPleural pathological changes were not seldom seen in coal miner's pneumoconiosis. HRCT is a reliable examination method aiding routine CT to show pleural pathological changes, thus it has a great diagnostic and practical value. It is necessary to make a further comparison study between pathology and imagology.

Adult ; Aged ; Aged, 80 and over ; Coal Mining ; Humans ; Lung ; diagnostic imaging ; pathology ; Male ; Middle Aged ; Pleura ; diagnostic imaging ; pathology ; Pleural Diseases ; diagnosis ; Pneumoconiosis ; diagnosis ; Tomography, X-Ray Computed ; methods

OBJECTIVETo study the diagnostic value of CT/HRCT for the coal workers' pneumoconiosis (CWP) with large opacities.

METHODSSixty-two patients with CWP were examined with both chest radiograph and CT/HRCT scan. Comparison was done.

RESULTSLarge opacities were found in 19 patients in the chest radiograph of 62 patients with CWP. The detection rate was 30.6%. Thirty large opacities were found using chest radiograph. Forty-three patients with large opacities were found using the CT/HRCT. The detection rate was 69.4%. One hundred and twenty-three large opacities were found using CT/HRCT. Ninety-three more large opacities were found by CT/HRCT than by chest radiograph. The total detection rate of large opacities by CT was 4.1 times than by chest radiograph. Both differences were statistically significant (chi2 = 18.58, P < 0.01). CT/HRCT found all patients with large opacities detected in the chest radiograph. Seventeen patients with Stage III large opacities (>or= 1.0 cm x 2.0 cm) were found by the chest radiograph. The detection rate was 27.4% (17/62). Twenty-seven large opacities were found using chest radiograph. Thirty-four patients with Stage III large opacities were found using the CT/HRCT. The detection rate was 54.8%. The found Stage III large opacities added up to 67. The found Stage III large opacities by CT/HRCT were 40 more than using chest radiograph. Both differences were statistically significant (chi2 = 9.63, P < 0.01). CT/HRCT was reliable to show the morphology, the inside structure, the tiny lesion and the special location of the large opacities of CWP. It could provide more important information for differential diagnosis.

CONCLUSIONCT/HRCT is significantly better than the chest radiograph in the diagnosis of complicated CWP. It can find the large opacities that the chest radiograph can not. It has a great diagnostic and practical value as an assistant examination method. CT/HRCT could be considered as the reference and evidence for staging progression in diagnosis of pneumoconiosis.

Adult ; Aged ; Aged, 80 and over ; Anthracosis ; diagnostic imaging ; Coal Mining ; Humans ; Male ; Middle Aged ; Tomography, X-Ray Computed ; methods

Objective To investigate the feasibility of LAMP detection in Pneumocystis carinii pneumonia rats and the changes of 1, 3-β-D-glucan.Methods 40 Wister rats were randomly divided into control group and lung infection group, 20 rats in each group.Specific primers were designed for pneumoniae carinii and LAMP technique was carried out to identify whether the rats were infected or not.The levels of 1, 3-β-D-glucan in peripheral blood and lung lavage fluid were detected by ELISA.Results Compared with the control group, there were 4 dead rats in the lung infection group, the body weight decreased significantly, and the lung weight and the percentage of the lung volume increased significantly (P＜0.05).LAMP method can detect Pneumocystis carinii, the control group was negative.Compared with the control group, the level of 1, 3-β-D-glucan in peripheral blood and lung lavage fluid in the lung infection group increased.And the 1, 3-β-D-glucan level in lung lavage fluid was higher than that in peripheral blood (P＜0.05).Conclusion In this study, we successfully constructed a rat model of Pneumocystis carinii pneumonia and established a simple and rapid method for LAMP detection of Pneumocystis carinii.1, 3-β-D-glucan and Pneumocystis carinii have some relevance.

Along with the further aging of Chinese population, the number of elderly patients with heart failure is mounting rapidly, while hemodynamic monitoring plays an important role in the treatment of elderly patients with complex hemodynamic states and multiple diseases. Pulse indicated continuous cardiac output (PICCO) can quickly, effectively, continuously and safely perform hemodynamic monitoring and guide precise treatment, which is of great practical significance for improving the quality of life, prognosis and prolonging the effective life time of elderly patients with heart failure. This article reviews the characteristics of senile heart failure, the clinical application, safety and characteristics of PICCO.

Objective: To explore the clinical, imaging and pathological characteristics of mandibular peripheral primitive neuroectodermal tumors, and to review relevant literature to improve the understanding and diagnosis of pPNET in mandible. Methods: The clinical and imaging features, pathological examination, treatment and prognosis of a case of mandibular pPNET diagnosed and treated at the First Affiliated Hospital of Xinjiang Medical University were observed, and analyzed a literature review. Results : The patient′s clinical manifestations were an enlarged mass of the mandible, hard texture, unclear borders, involving loose teeth, and numbness of the lower lip; CT and MRI showed osteolytic and aggressive growth patterns. The mandibular tumor was resected and the mandibular partial truncated resection was performed on the titanium plate. Postoperative pathological sections showed small round cell tumors under HE staining and Vimentin and Fli-1 were positive, and the pathological diagnosis was pPNET. The patient did not undergo chemoradiotherapy after surgery and died of tumor recurrence after 9 months of follow-up. A review of the relevant literature revealed that pPNETs are a group of small round cell tumors, which are more common in children and adolescents. pPNETs have a high degree of malignancy, a short course of disease and fast metastasis. The main route of metastasis is through the blood circulation. Most patients die within 2 years, the 3-year survival rate is only 30%, and the 5-year survival rate is less than 10%. Imaging is generally nonspecific; therefore, pPNETs are easily misdiagnosed. The final tumor type is determined by pathological HE staining and immunohistochemical characteristics. Current treatment methods are mainly complete surgical resection combined with postoperative radiotherapy and chemotherapy, but it is critical to provide individualized treatment to patients when necessary. Conclusion pPNETs have a high degree of malignancy, easy recurrence and poor prognosis, so early diagnosis and treatment are extremely important.

OBJECTIVE To investigate the types and differences of allergens in patients with allergic rhinitis(AR)in Kashgar,Xinjiang,and to provide a research basis for its treatment and prevention.METHODS A retrospective analysis was conducted on the data of AR patients diagnosed in the First People's Hospital of Kashgar from July 2015 to December 2020.The specific IgE(sIgE)results of peripheral venous blood and the types of allergens were analyzed.The patients were grouped according to gender,ethnicity and age,and the differences in allergens among the groups were further analyzed.RESULTS Among the sIgE test results of 528 AR patients,the highest positive rate was for dust mites(246 cases,46.6％),followed by egg,Alternaria alternata/Aspergillus fumigatus/Cladosporium herbarum and so on.There was a statistically significant difference in the dog epithelium allergen positive rate between males and females(P＜0.05),and a statistically significant difference in the positive rate of tomato allergen detection among different age groups,while there was no statistically significant difference in the allergen positive rate among different ethnic groups.CONCLUSION Dust mites,egg,and Alternaria alternata/Aspergillus fumigatus/Cladosporium herbarum are the most common allergens in patients with AR in Kashgar.