1.Prescribing rate, healthcare utilization, and expenditure of older adults using potentially inappropriate medications in China: A nationwide cross-sectional study.
Zinan ZHAO ; Mengyuan FU ; Can LI ; Zhiwen GONG ; Ting LI ; Kexin LING ; Huangqianyu LI ; Jianchun LI ; Weihang CAO ; Dongzhe HONG ; Xin HU ; Luwen SHI ; Xiaodong GUAN ; Pengfei JIN
Chinese Medical Journal 2025;138(23):3163-3167
BACKGROUND:
The use of potentially inappropriate medications (PIMs) is a major concern for medication safety as it may entail more harm than potential benefits for older adults. This study aimed to explore the prescribing rate, healthcare utilization, and expenditure of older adults using PIMs in China.
METHODS:
A cross-sectional analysis was conducted using a national representative database of all medical insurance beneficiaries across China, extracting ambulatory visit records of adults aged 65 years and above between 2015 and 2017. Descriptive analysis was conducted to measure the rate of patients exposed to PIM, prescribing rate of each PIM, average annual outpatient visits per patient, average total medication costs for each visit, average annual cost of PIMs for each patient, and average annual medication costs for each patient. Generalized linear model with logit link function and binomial distribution was used to examine the adjusted associations between PIMs and independent variables.
RESULTS:
In total, 845,278 (33.2%) participants were identified to be exposed to at least one PIM. Patients aged 75-84 years (38.1%, 969,809/2,545,430) and ≥85 years (37.9%, 964,718/2,545,430) were more likely to be prescribed with PIMs. Beneficiaries of the Urban Employee Basic Medical Insurance (UEBMI) and living in eastern and southern regions were more frequently prescribed with PIMs. Compared with patients without PIM exposure (7.5 visits, drug cost of RMB 1545.0 Yuan), patients with PIM exposure showed higher adjusted average annual number of outpatient visits (10.7 visits, β = 3.228, 95% confidence interval [CI] = 3.196-3.261) and higher annual drug costs (RMB 2461.8 Yuan, Coef. = 916.864, 95% CI = RMB 906.292-927.436 Yuan).
CONCLUSIONS
The results showed that the use of PIM among older adults was common in China. This study suggests that the use of PIM could be considered as a clear target, pending multidimensional efforts, to promote rational prescribing for older adults.
Humans
;
Aged
;
Cross-Sectional Studies
;
Aged, 80 and over
;
Male
;
Female
;
China
;
Inappropriate Prescribing/economics*
;
Patient Acceptance of Health Care/statistics & numerical data*
;
Potentially Inappropriate Medication List/statistics & numerical data*
;
Health Expenditures/statistics & numerical data*
2.Analysis of factors related to voice training compliance.
Caipeng LIU ; Jinshan YANG ; Wenjun CHEN ; Xin ZOU ; Yajing WANG ; Yiqing ZHENG ; Faya LIANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2025;39(7):610-623
Objective:To explore the factors influencing adherence to voice therapy among patients with voice disorders in China. Methods:Patients with voice disorders who visited the Voice Therapy Center at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, from February to May 2022 were enrolled in the study. Adherence was assessed using the URICA-Voice scale, while influencing factors were assessed through the Voice Handicap Index(VHI) scale and a general information questionnaire. Correlation analysis was conducted using univariate and multivariate logistic regression analysis. Results:A total of 247 patients were included in the study, comprising 57 males(23.08%) and 190 females(76.92%). The results revealed that: ①Female patients demonstrated higher likelihood of being in the contemplation stage(OR=0.22) compared to males. ②Patients with a monthly family income per capita>6 000 yuan were more likely to be in the contemplation stage than those with<3 000 yuan with an OR = 13.94. ③High vocal-demand occupations increased contemplation stage probability(OR=7.70) compared to moderate-demand occupations. ④Residence within 30-minute commute predicted action/maintenance stages(OR=7.14) versus≥60-minute commute. ⑤Patients whose occupations had high voice demands were more likely to be in the action and maintenance stages than those with average voice demands, with an OR of 16.20. Conclusion:Gender, monthly family income per capita, occupational voice demands, and distance to the hospital significantly impact the URICA-Voice compliance stages of patients. Patients who are female, have higher family income, have occupations with high voice demands, and live closer to the hospital exhibit higher compliance with voice training.
Humans
;
Male
;
Female
;
Voice Disorders/therapy*
;
Patient Compliance
;
Voice Training
;
Surveys and Questionnaires
;
China
;
Middle Aged
;
Adult
;
Voice Quality
;
Logistic Models
;
Aged
3.Factors associated with medication compliance among hypertensive patients in Barangay Sambag II, Cebu City.
Katrina Isabel A. Abesta ; Stacy Gayle N. Auza ; Avinash Suram ; Francis Keith A. Oludin ; Jonathan P. Abrenilla ; Joy Ochoyafie Oche ; Maria Dawn F. Amante ; Millicent C. Abayan ; Pamela Kaye B. Pandili ; Rex Moller Q. Palmes ; Yanilen A. Noynay ; Anacleto Clent L. Banaay jr. ; Marvin C. Masalunga
Acta Medica Philippina 2025;59(Early Access 2025):1-7
BACKGROUND
Medication compliance contributes to preventing significant morbidities, such as stroke, among hypertensive patients.
OBJECTIVEThis study aimed to examine the factors affecting hypertensive patients' medication compliance in Sambag II, Cebu City.
METHODSThis study is an observational cross-sectional study. The study was conducted in Barangay Sambag II of Cebu City and involved 170 random, voluntary, self-reporting hypertensive patients. The Tao Yamane formula was used to determine the sample size. An interviewer-guided survey questionnaire was utilized to collect the data for the pilot study. The data were analyzed using Cronbach’s Alpha Test for internal consistency and reliability.
RESULTSThree factors were shown to influence compliance with antihypertensive medications. These are the source of medication, access to medication, and symptoms experienced before intake of anti-hypertensive medications. A factor that significantly affects compliance is the source of medication, wherein hypertensive patients prefer medications from retail pharmacies compared to the free medications supplied by the local health center.
CONCLUSIONResidents of Sambag II, Cebu City preferred medications from retail pharmacies over the free medications provided by the local health center. Local health units may use this information to implement information drugs regarding the efficacy of medications provided by government agencies. Further studies are recommended to use subgroup analysis on factors influencing compliance and non-compliance to anti-hypertensive medicines.
Human ; Medication Compliance ; Medication Adherence ; Hypertension ; Stroke
4.Clinical exploration and practice of a 16-step new model of comfortable supragingival scaling.
Yue CHEN ; Jinyang LI ; Yazheng WANG ; Jing LI ; Jin LIU ; Yumeng ZHOU ; Ang LI
West China Journal of Stomatology 2025;43(5):628-635
Comfortable supragingival scaling uses ultrasonic cleaning with sedation and minimally invasive techniques to minimize the negative emotions of patients and improve patient compliance. At present, there is still much room for optimization of the environment, equipment, and operation steps for the development of comfortable supragingival scaling. On this basis, the Department of Periodontology, College of Stomatology, Xi'an Jiaotong University proposed a 16-step new model of comfortable supragingival scaling. The new model incorporates adjustments to the previous model concerning the environment, equipment, operational procedures, process links and services, comprising 16 steps for optimization and innovation. Clinical practice has confirmed that the 16-step new model of comfortable supra-gingival scaling can significantly improve patient satisfaction and adherence to medical treatment, and it has good promotional value.
Humans
;
Dental Scaling/instrumentation*
;
Patient Satisfaction
;
Patient Compliance
;
Gingiva
5.Towards integrated and quality-assured health service delivery: Making a case for health smart card in the Philippines
Kenneth Y. Hartigan-go ; Melissa Louise M. Prieto ; Angel Faye G. Castillo ; Ella Mae C. Eleazar
Acta Medica Philippina 2025;59(10):7-20
BACKGROUND AND OBJECTIVE
In the Philippines, patients are constrained from accessing their own records, restricting their ability to freely choose who to seek care from. To address this, the study makes a case for the development of the health smart card in the Philippines, an integrative tool unique to each citizen carrying their lifetime medical record.
METHODSThe prototype is developed using no-code programming technology and validated through a series of focus group discussions and stakeholder consultations with patients (n=4), healthcare administrators (n=4), and hospital personnel (n=13). It was then revised based on the collected insights and recommendations.
RESULTSFindings report that the current facility-centric model utilizing paper records constrains patients’ access to their records due to long wait times, slow turnaround periods, constant intra- and inter-hospital transfers, and even charging of fees to acquire a copy of their own data. The health smart card alternative was widely accepted by the participants, particularly for its contribution to increasing data accessibility, patient empowerment, and advancing patient data ownership. Nevertheless, several considerations for the upscale implementation of the health smart card emerged, including creating an interoperable environment through harmonizing standards and capacity-building programs, and ensuring data security through robust cybersecurity measures. Issues on scalability and funding of the project were also raised, centering on the critical role of the government in stepping up as regulator and potential funder. Concerns over potential abuse, dataveillance, and the digital divide are tackled, highlighting the need to account for socioeconomic factors to ensure that no one is left behind in the implementation.
CONCLUSIONThe study makes a case for the development and adoption of a health smart card to address the inaccessibility of records to patients. The study concludes by recommending the conduct of a pilot implementation to comprehensively demonstrate and analyze the features of the proposed scheme.
Health Smart Cards ; Patient Participation ; Philippines
6.Factors associated with medication compliance among hypertensive patients in Barangay Sambag II, Cebu City.
Katrina Isabel A. ABESTA ; Stacy Gayle N. AUZA ; Avinash SURAM ; Francis Keith A. OLUDIN ; Jonathan P. ABRENILLA ; Joy Ochoyafie OCHE ; Maria Dawn F. AMANTE ; Millicent C. ABAYAN ; Pamela Kaye B. PANDILI ; Rex Moller Q. PALMES ; Yanilen A. NOYNAY ; Anacleto Clent L. BANAAY JR. ; Marvin C. MASALUNGA
Acta Medica Philippina 2025;59(18):9-15
BACKGROUND
Medication compliance contributes to preventing significant morbidities, such as stroke, among hypertensive patients.
OBJECTIVEThis study aimed to examine the factors affecting hypertensive patients' medication compliance in Sambag II, Cebu City.
METHODSThis study is an observational cross-sectional study. The study was conducted in Barangay Sambag II of Cebu City and involved 170 random, voluntary, self-reporting hypertensive patients. The Tao Yamane formula was used to determine the sample size. An interviewer-guided survey questionnaire was utilized to collect the data for the pilot study. The data were analyzed using Cronbach’s Alpha Test for internal consistency and reliability.
RESULTSThree factors were shown to influence compliance with antihypertensive medications. These are the source of medication, access to medication, and symptoms experienced before intake of anti-hypertensive medications. A factor that significantly affects compliance is the source of medication, wherein hypertensive patients prefer medications from retail pharmacies compared to the free medications supplied by the local health center.
CONCLUSIONResidents of Sambag II, Cebu City preferred medications from retail pharmacies over the free medications provided by the local health center. Local health units may use this information to implement information drugs regarding the efficacy of medications provided by government agencies. Further studies are recommended to use subgroup analysis on factors influencing compliance and non-compliance to anti-hypertensive medicines.
Human ; Medication Compliance ; Medication Adherence ; Hypertension ; Stroke
7.Is satisfaction with the medication provisions of the Senior Citizens Act and frequency of senior identification card use associated with medication compliance among hypertensive patients in the Philippines?.
Nativity R. LABBAO ; Mary Kriznah S. HIDALGO ; Ram Joseph D. DOROLIAT ; Daisy-mae ALEGADO-BAGAOISAN ; Kevin Jace A. MIRANDA ; Rogie Royce Z. CARANDANG
Acta Medica Philippina 2025;59(17):16-23
BACKGROUND
Long-term treatment and medication compliance are critical for managing conditions like hypertension, yet only 20% of cases are well-controlled, mainly due to socioeconomic factors. The Expanded Senior Citizens Act of 2010 offers a 20% discount on medications to improve compliance, but many seniors need to be made aware of these benefits. Evaluating satisfaction with the Act, specifically regarding its medication-related provisions, is essential for enhancing compliance and health outcomes among senior citizens.
OBJECTIVEThis study examined the association between satisfaction with the medication provisions of the Senior Citizens Act, the frequency of senior identification card usage, and medication compliance among hypertensive patients.
METHODSWe conducted a community-based cross-sectional study with 458 hypertensive senior citizens in Dasmariñas City, Cavite, Philippines. Senior citizens were randomly selected and completed a survey using a validated, self-developed questionnaire and the Hill-Bone High Blood Pressure (HB-HBP) compliance scale. We performed linear regression analysis to examine the association between their satisfaction and the use of senior citizens’ benefits on their medication compliance.
RESULTSSenior citizens were 60-88 years old (mean 69; standard deviation [SD] 5.9). Thirty-eight percent were satisfied with the Senior Citizens Act and 49% regularly used their senior citizen card. Senior citizens scored an average of 46.82 (SD 4.96) on the HB-HBP compliance scale (possible range = 14-56), indicating high compliance. Those dissatisfied with the Senior Citizens Act were less compliant with their antihypertensive medications [B (unstandardized beta) = -1.65, 95% CI (Confidence Interval) = -2.70, -0.61]. Similarly, those who rarely or never used their senior identification cards (B = -1.54, 95% CI = -2.61, -0.48) and those who used them occasionally (B = -1.43, 95% CI = -2.57, -0.29) showed lower medication compliance compared to those who used them regularly.
CONCLUSIONSenior citizens who are satisfied with the medication provisions of the Act and regularly use their senior identification cards exhibit higher compliance with their antihypertensive medications than those with lower satisfaction and infrequent card usage. Interventions should prioritize educational sessions to inform senior citizens about the benefits of the Senior Citizens Act, including how to use their identification cards to access medication discounts effectively.
Human ; Hypertension ; Medication Adherence ; Philippines ; Satisfaction ; Personal Satisfaction
8.COVID-19 vaccine acceptance among kidney transplant recipients in Singapore.
Ian Tatt LIEW ; Hanis Abdul KADIR ; Sobhana THANGARAJU ; Quan Yao HO ; Eleanor NG ; Fiona FOO ; Terence KEE
Singapore medical journal 2025;66(2):73-80
INTRODUCTION:
A successful vaccination programme forms the cornerstone of controlling coronavirus disease 2019 (COVID-19). The unprecedented speed of COVID-19 vaccine development and lack of long-term data have raised fears regarding its safety and efficacy. Vaccine hesitancy can undermine the uptake, and hence success of the vaccination programme. Given the high complication rates of COVID-19 infections in kidney transplant recipients, it is particularly important to identify and address vaccine hesitancy in this population.
METHODS:
We conducted a cross-sectional survey among kidney transplant recipients attending transplant clinic between 5 April and 5 May 2021. The survey assessed attitudes towards COVID-19, willingness/hesitancy towards COVID-19 vaccination, vaccination concerns and prompts to vaccination. This was scored on a Likert scale with scores ranging from 'strongly disagree' - 1 point to 'strongly agree' - 5 points.
RESULTS:
One hundred and one completed responses were captured. Of these, 86% respondents reported to agree or strongly agree to vaccination. This was despite significant concerns of allograft rejection (mean score 4.12, standard deviation [SD] 0.97) and decreased immunosuppressant efficacy (mean score 4.14, SD 0.96) with vaccination. Multivariable model showed a positive association with transplant vintage of ≥ 5 years (median 2.41), lower educational levels of secondary school or less (median 5.82) and healthcare provider advocacy (median 1.88) in predicting vaccine acceptance.
CONCLUSIONS
Vaccine acceptance rate was high among kidney transplant recipients. Vaccine hesitancy remains a concern in those with a transplant vintage of less than 5 years and those with tertiary educational level. Healthcare provider advocacy is important in improving vaccine acceptance rates.
Humans
;
Kidney Transplantation
;
Singapore/epidemiology*
;
Male
;
Cross-Sectional Studies
;
Female
;
COVID-19 Vaccines
;
COVID-19/epidemiology*
;
Middle Aged
;
Adult
;
Transplant Recipients/psychology*
;
Patient Acceptance of Health Care/statistics & numerical data*
;
Vaccination Hesitancy/psychology*
;
Surveys and Questionnaires
;
Vaccination/psychology*
;
Aged
;
SARS-CoV-2
9.Adolescent self-harm and suicide attempts: An analysis of emergency department presentations in Singapore.
Darren Kai Siang CHONG ; Vicknesan Jeyan MARIMUTTU ; Pei Shan HOE ; Chu Shan Elaine CHEW ; Angelina Su Yin ANG
Annals of the Academy of Medicine, Singapore 2025;54(2):78-86
INTRODUCTION:
The rising rate of adolescent suicide, and the burden of self-harm and mental health disorders, pose significant threats to Singapore's future health outcomes and human potential. This study sought to examine the risk profile and healthcare utilisation patterns of Singaporean adolescents who presented to the emergency department (ED) for suicidal or self-harm behaviour.
METHOD:
A retrospective review of medical records for patients aged 10 to 19 years who visited Singapore's KK Women's and Children's Hospital ED for suicidal or self-harm attempts from January to December 2021 was conducted.
RESULTS:
A total of 221 patients were identified, with a predominance of female patients (85.5%) over males (14.5%). The mean age was 14.2 ± 1.4 years. Intentional drug overdose (52.0%) was the most commonly used method. Significantly more females presented for intentional paracetamol overdose (46.6% versus [vs] 28.1%, P=0.049), whereas jumping from a height was more common among males (18.8% vs 5.8%, P=0.022). The most frequently observed mental health challenges were stress-related and emotional coping difficulties (50.7%), followed by mood and anxiety symptoms (53.4%). A history of self-harm and suicidal behaviours were the most common psychosocial risk factors. Within the year prior to their ED presentation, 15.4% had accessed healthcare services for mild medical ailments, 19.5% for medically unexplained symptoms, and 17.2% for previous self-harm or suicide attempts.
CONCLUSION
Most cases involved psychosocial and emotional regulation difficulties, some of which displayed sex-specific patterns, rather than complex psychiatric disorders. The identified predictive factors can help inform Singapore's National Mental Health and Well-being Strategy, to guide targeted and transdiagnostic interventions in schools and community settings.
Humans
;
Adolescent
;
Singapore/epidemiology*
;
Female
;
Male
;
Suicide, Attempted/psychology*
;
Emergency Service, Hospital/statistics & numerical data*
;
Self-Injurious Behavior/psychology*
;
Retrospective Studies
;
Child
;
Young Adult
;
Drug Overdose/epidemiology*
;
Risk Factors
;
Acetaminophen/poisoning*
;
Patient Acceptance of Health Care/statistics & numerical data*
;
Sex Factors
10.iPARTY study: Increasing pre-exposure prophylaxis access and reach via telehealth for young men who have sex with men in Singapore 2022-2023.
Pei Hua LEE ; Justin Y LIM ; P Arun KUMAR ; Zhi Hui TAN ; Rayen Bing Hui TAN ; Chiaw Yee CHOY ; Rayner Kay Jin TAN ; Martin Tw CHIO ; Chen Seong WONG
Annals of the Academy of Medicine, Singapore 2025;54(3):160-169
INTRODUCTION:
Although pre-exposure prophylaxis (PrEP) has been available in Singapore since 2016, its uptake among gay, bisexual and other men-who-have-sex-with-men (GBMSM) is low. The iPARTY study was established to evaluate the acceptability and feasibility of PrEP and a PrEP teleconsultation service for young GBMSM aged 18 to 29 years.
METHOD:
A total of 53 young GBMSM were enrolled in the iPARTY study. They had a total of 5 in-person consultations and teleconsultations, at 12-week intervals. Laboratory tests and quarterly baseline surveys were performed to assess PrEP adherence, sexual behaviour, and incidence of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs).
RESULTS:
Thirty-five participants completed the entire 12-month follow-up. Most participants had positive experiences with PrEP teleconsultations. There was a statistically significant fall in participants' aggregate Patient Health Questionnaire-9 scores throughout the study. Self-reported PrEP adherence decreased over the course of the study, denoting improved mental health. Although self-reported condom use for anal intercourse and participants' risk perception of HIV decreased after PrEP adoption, there was no statisti-cally significant increase in STI incidence.
CONCLUSION
This pilot project has shown that PrEP services provide an opportunity for YMSM to access sexual health testing, treatment and counselling, and may even have tangible benefits on the mental health of this population. Teleconsultation is shown to be a suitable platform for the delivery of such services. Collaborative initiatives are crucial to further enhance the affordability and accessibility of PrEP in Singapore, and to improve patient adherence.
Adolescent
;
Adult
;
Humans
;
Male
;
Young Adult
;
Anti-HIV Agents/administration & dosage*
;
Feasibility Studies
;
Health Risk Behaviors
;
HIV Infections/psychology*
;
Incidence
;
Medication Adherence
;
Mental Health/statistics & numerical data*
;
Pilot Projects
;
Pre-Exposure Prophylaxis/statistics & numerical data*
;
Sexual and Gender Minorities/statistics & numerical data*
;
Sexually Transmitted Diseases/prevention & control*
;
Singapore/epidemiology*
;
Telemedicine/statistics & numerical data*
;
Homosexuality, Male/statistics & numerical data*


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