China ; Pathology, Oral ; trends

China ; Humans ; Pathology, Oral

The aim of this study was to determine the profile of patients referred to a specialist oral medicine and oral pathology unit in Kuala Lumpur by reviewing clinical dental records received in Oral Pathology Diagnostic Service (OPDS) in Faculty of Dentistry, UKM from 2001 until 2010. A total of 547 archival biopsy clinical dental records were reviewed and analysed using SPSS version 17.0. Oral and maxillofacial diseases were frequently seen in female (1.3:1), young adults (30.0%) of Malay ethnicity (64.6%). Most of the acquired specimens were from dental specialists (n=451, 84.8%), particularly from oral and maxillofacial surgeons (OMFS) (n=349, 63.8%) compared to general dental practitioners (GDPs) (n=81, 14.8%). Almost all of the biopsy specimens were of soft tissue origin (n=462, 84.4%), derived from lining mucosa (n=197, 36.0%) and were biopsied excisionally (n=325, 59.4%) more often than by incisional biopsy (n=207, 37.8%). A large proportion of the oral and maxillofacial diseases were of reactive (n=188, 34.4%) and inflammatory (n=121, 22.1%) cause. Tumours are mainly benign (n=69, 12.6%) with only small cases are malignant (n=34, 6.2%). The most common histological diagnoses were accounted by mucocele (n=56, 10.2%), pyogenic granuloma (n=47, 8.6%), fibroepithelial polyp (n=38, 6.9%), radicular cyst (n=33, 6.0%) and periapical granuloma (n=29, 5.3%). This study characterizes the clinical profile of patients seen in our oral medicine and oral pathology unit. Present findings can be used as a reference to the clinicians and pathologists in effective patient management and organization in the future.
Oral Medicine ; Biopsy ; Prevalence ; Pathology, Oral

PURPOSE: To evaluate the efficacy of a modified small bowel follow-through (SBFT) and to optimize this technique. MATERIALS AND METHODS: Ninety-nine subjects without small bowel pathology underwent modified SBFT using oral administration of methylcellulose after taking 100ml of 120% or 100, 150, or 200ml of 70% barium. Thirty-three and 39 normal subjects undergoing enteroclysis or conventional SBFT, respectively, were also evaluated for comparison of image qualities and transit time. RESULTS: Enteroclysis was the most successful ofthree types of small bowel examination for obtaining the best quality of bowel transradiency and distension. Modified SBFT was, however much superior to the conventional series for obtaining good bowel transradiency and rapid transity time (mean, 37-49 minutes). The use of 150ml of 70% barium was better than the other three modified techniques in achieving good bowel transradiency, rapid transit time, and less flocculation. CONCLUSION: Our modified SBFT is a simple and safe method for easily improving bowel transradiency and transit time.
Administration, Oral ; Barium ; Flocculation ; Methylcellulose* ; Pathology

Collecting, managing and processing course material requires of much costs and efforts while they include a variety of data types particularly in the health field. Some engineering work on the material may help reduce the workload and costs to some extent. With such benefits having in mind, this paper tries to develop multimedial database for the course material of Oral Pathology in dental schools. It provides structured analysis of data for the course material, in which a unit of disease is a central class with relation to many other classes. It also achieved data independence from server applications by using the method concept of object-oriented database(OODB), which will increase reusability of the course data. Using another important concept of OODB, the system devised many functional utilities on an Internet web server including lecture notes, case studies, disease search, and question and answer, and shows how they are operated. But the effectiveness for the part of student users may remain to be evaluated.
Humans ; Internet ; Learning* ; Pathology, Oral* ; Schools, Dental

Objectives: Diabetes mellitus is associated with a greater likelihood of developing certain oral mucosal disorders. This study was aimed at assessing the prevalence of oral mucosal lesions (OMLs) in patients with type 2 diabetes (DM2) and to investigate the association of such lesions with metabolic control of the disease. Methods: This cross-sectional study involved 391 patients with DM2 and 391 non-diabetic control subjects. Demographic information and data on the duration and type of diabetes, glycosylated hemoglobin (HbA1c) values, medical history, and current use of medication were obtained from medical records. Detailed oral examination was performed in accordance with international criteria. Results: The prevalence of OMLs was significantly higher among diabetic patients (45.5%) than among control subjects (38.4%) (P = 0.042). Patients with diabetes had a higher prevalence of geographic tongue (GT) (P = 0.017), denture stomatitis (P = 0.018), and angular cheilitis (P = 0.006) than controls. Overall, diabetic patients with poor metabolic control had a significantly higher prevalence of OMLs and xerostomia than patients with moderately and well-controlled disease (P < 0.05). Conclusions: The prevalence of OMLs was significantly higher in diabetic patients than in control subjects. Higher occurrence of OMLs was significantly associated with poor metabolic control.
Diabetes Mellitus, Type 2 ; Mouth Mucosa ; Pathology, Oral ; Prevalence

Humans ; Lichen Planus, Oral ; pathology ; Mouth Neoplasms ; pathology ; Precancerous Conditions ; pathology

OBJECTIVEThe purpose of this study was to investigate the relationship between apoptosis and proliferation of oral mucosa in lesions of leukoplakia and the role of apoptosis in the pathogenesis of this common oral disease.

METHODSThe mucosa was obtained from the leukoplakia lesions from 6 patients, with average age of 57 years, and all the patients had not received any treatment before this investigation. The lesions were located on the lip (1), gingiva (1), tongue (2) and buccal mucosa (2). All the patients did not have any systemic diseases. Other three normal oral mucosa tissues were collected as the control. In situ terminal deoxynucleotidyl transferase end-labeling (TUNEL) and avidin-biotin peroxidase complex (ABC) immunohistochemical assay were used to detect single-strand DNA breaks and proliferating cell nuclear antigens (PCNA). The negative control slides were treated with the tris saline buffer to substitute the terminal deoxynucleotidyl transferase (TdT) and PCNA-Ab in the assay. Five consecutive high power fields with the magnification of 400 were used to search for positive stained keratinocytes.

RESULTSCompared with the normal mucosa, the keratinocytes in leukoplakia showed positive apoptotic signals in the nucleus of suprabasal epithelial layers, while PCNA-positive stain was present in the basal position. In the connective tissue, positive apoptotic signals were found in lymphocytes and the endothelia of blood vessels.

CONCLUSIONThe results indicate that the death of cells in leukoplakia is partly due to apoptosis which may play an important role in the genesis of oral leukoplakia.

Aged ; Apoptosis ; Epithelial Cells ; pathology ; Female ; Humans ; Keratinocytes ; pathology ; Leukoplakia, Oral ; pathology ; Male ; Middle Aged ; Mouth Mucosa ; pathology

OBJECTIVETo analyze the clinical and pathological features of 40 patients with secondary syphilis.

METHODSA total of 40 cases of secondary syphilis confirmed by serology were collected during 1994-2004 and were first diagnosed on presentation with oral lesions.

RESULTSThe white patch in oral mucosa was found in 32 cases with painless or slight pain in most cases. The most common site of the lesion was the tongue. The histological examination on eight cases was initially misdiagnosed as oral candidosis or lichen planus, but confirmed as syphilis after serology revealed nonspecific inflammation with intraepithelial microabscess and dense perivascular infiltration of lymphocytes and plasma cells in connective tissue. The symptoms showed dramatic improvement in 16 cases after benzathine penicillin treatment.

CONCLUSIONSThe oral manifestations of syphilis have specific clinical and pathological feature and attention should be paid to the suspicious oral lesions when patients are first presented in a dental office.

Adult ; Female ; Humans ; Male ; Middle Aged ; Mouth Mucosa ; pathology ; Oral Ulcer ; etiology ; Syphilis ; complications ; diagnosis ; pathology

Adult ; Blister ; pathology ; Female ; Humans ; Lichen Planus, Oral ; pathology ; Middle Aged