Humans ; Parvoviridae Infections ; virology ; Parvovirus B19, Human ; genetics ; metabolism ; physiology

Bocavirus ; isolation & purification ; Child, Preschool ; Humans ; Infant ; Parvoviridae Infections ; diagnosis ; etiology ; Respiratory Tract Infections ; diagnosis ; etiology

Bocavirus ; isolation & purification ; Humans ; Infant ; Male ; Oligonucleotide Array Sequence Analysis ; methods ; Parvoviridae Infections ; diagnosis ; Pneumonia ; diagnosis

The association between aplastic crisis and human parvovirus (HPV) B19 infection is well described in patients with sickle cell anemia. This association has also been described, although much less frequently, in patients with hereditary spherocytosis (HS). However, most cases of aplastic crises in patients with HS and induced by HPV B19 have been reported in children or adolescents. In this paper, we describe an aplastic crisis induced by HPV B19 in an adult with HS. A 34-year-old female presented with presyncope, febrile sensation, and myalgia. The complete blood counts showed severe anemia. The peripheral blood smear revealed spherocytosis with reticulocytopenia and pancytopenia. The direct Coombs' test was negative; the osmotic fragility test was positive. In the bone marrow aspirates, a few giant pronormoblasts with deep blue cytoplasm, pseudopods, and intracellular inclusion bodies were observed. The patient was given eight units of packed red blood cells. HPV B19 infection was proven by the presence of IgM antibodies to HPV B19 and the detection of viral DNA using the PCR technique. To the best of our knowledge, this is the first report in Korea that describes an adult with aplastic crisis presenting initially with HS.
Adult ; Anemia, Aplastic/*etiology ; Female ; Humans ; Parvoviridae Infections/*complications/diagnosis ; Parvovirus B19, Human ; Spherocytosis, Hereditary/*diagnosis

Gastroenteritis ; etiology ; virology ; Human bocavirus ; isolation & purification ; Humans ; Parvoviridae Infections ; diagnosis ; Respiratory Tract Diseases ; etiology ; virology

Until now, more than seventeen parvovirus have been reported which can infect mammals and poultries. The infected cells appeared different properties of apoptosis and death, present a typical cytopathic effect. NS1 is a major nonstructural protein of parvovirus, with a conservative structure and function, which plays an important role in the viral life cycle. In addition to the influence on viral replication, the NS1 also participates in apoptosis induced by viruses. Parvovirus induced apoptosis which is mainly mediated by mitochondrial pathway, this review summarized the latest research progresses of parvovirus induced apoptosis.
Animals ; Apoptosis ; Humans ; Parvoviridae Infections ; physiopathology ; veterinary ; virology ; Parvovirus ; genetics ; metabolism ; Viral Nonstructural Proteins ; genetics ; metabolism

Child ; China ; epidemiology ; Female ; Human bocavirus ; Humans ; Infant ; Infant, Newborn ; Male ; Parvoviridae Infections ; epidemiology ; virology ; Respiratory Tract Infections ; epidemiology ; virology

China ; epidemiology ; Epidemiologic Studies ; Human bocavirus ; isolation & purification ; Humans ; Molecular Epidemiology ; Parvoviridae Infections ; epidemiology ; Respiratory Tract Infections ; epidemiology ; virology

Porcine bocavirus (PBoV) was considered as a new member of the genus Bocavirus of the subfamily Parvovirinae of the family Parvoviridae, which was discovered in Swedish swine herds with postweaning multisystemic wasting syndrome (PMWS) in 2009. At present, as an emerging pathogen, it was paid great attention by researchers at home and abroad. This paper referred to some published literatures and reviewed several aspects of PBoV including its finding, classification, genome structure and replication, epidemiology, associativity with diseases, cultural and diagnostic methods.
Animals ; Biomedical Research ; Bocavirus ; classification ; genetics ; isolation & purification ; physiology ; Parvoviridae Infections ; diagnosis ; veterinary ; virology ; Swine ; Swine Diseases ; diagnosis ; virology

Human bocavirus (HBoV) is classified in the family of parvovirdae, genus bocavirus. Besides parvovirus B19 and human parvovirus 4 (PARV4), HBoV isone of the parvoviruses currently known to infect and cause illness in human. So far, four different HBoVs (HBoV1-4) have been successively reported. The incidence of HBoVs infection varies widely, the clinical presentations of patients are different, and HBoVs are often co-detected with other pathogens. There are already quite a few report of HBoVs infection, and this article reviews and discusses the biological characters, epidemic characters, pathogenic mechanism, phylogenetic analyses of HBoVs and the epidemiological situation in China.
China ; epidemiology ; Gastrointestinal Diseases ; etiology ; Human bocavirus ; classification ; genetics ; immunology ; isolation & purification ; Humans ; Parvoviridae Infections ; epidemiology ; Phylogeny