1.Drug Therapy in Parkinson's Disease.
Journal of the Korean Medical Association 2000;43(9):902-923
No abstract available.
Drug Therapy*
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Parkinson Disease*
4.Effects of resveratrol-induced cellular autophagy in control of neurodegenerative diseases.
Acta Pharmaceutica Sinica 2016;51(1):18-22
Cellular autophagy is a major degradative pathway for clearance of aggregate-prone proteins and damaged organelles. It plays an important role in regulating cellular homeostasis, cell growth and development, and disease development. Dysfunctional autophagy contributes to the pathology of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, in which specific pathological protein accumulation occurs. A growing body of evidence suggests that resveratrol plays a significantly role in the regulation of autophagy and clearance of pathological proteins. Resveratrol is a potential drug for neurodegenerative diseases therapy. This review focuses on the effects of resveratrol on cellular autophagy and clinical application in the control of neurodegenerative diseases.
Alzheimer Disease
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Autophagy
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Humans
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Huntington Disease
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Neurodegenerative Diseases
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drug therapy
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Parkinson Disease
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Stilbenes
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pharmacology
6.Carnosine and diseases of central nervous system.
Yao SHEN ; Wei-Wei HU ; Zhong CHEN
Journal of Zhejiang University. Medical sciences 2007;36(2):199-203
The naturally-occurring dipeptide carnosine (beta-alanyl-L-histidine) is found exclusively in animal tissues, such as brain and skeletal muscle tissues. Carnosine is a potent hydrophilic antioxidant, antiglycating agent, reactive oxygen species scavenger and pH-buffer. Recent reports suggest that carnosine has potential therapeutic applications in many diseases of central nervous system, such as Alzheimer's disease, Parkinson's disease and cerebral ischemic diseases. To investigate the relationship between carnosine and diseases of central nervous system, and to research and develop carnosine drugs will shed light on a new way for treatment of diseases of central nervous system.
Alzheimer Disease
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drug therapy
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Brain Diseases
;
drug therapy
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Brain Ischemia
;
drug therapy
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Carnosine
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therapeutic use
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Central Nervous System Diseases
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drug therapy
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Humans
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Parkinson Disease
;
drug therapy
7.Clinical spectrum of Parkinson's disease.
Singapore medical journal 2007;48(5):484-author reply 486
8.Efficacy of Unilateral Pallidotomy for Parkinson's Diesease.
Woo Jin CHO ; Kyung Jin LEE ; Cheul JI ; Sung Chan PARK ; Hea Kwan PARK ; Jung Ki JO ; Kyung Keun CHO ; Hyung Kyun RHA ; Joon Ki KANG ; Chang Rak CHOI
Journal of Korean Neurosurgical Society 2001;30(8):976-980
OBJECTIVES: For Parkinsonian patients who had not reacted favorably on drug therapy are good candidate for ventroposterolateral pallidotomy, although not curative. We studied these patients after unilateral pallidotomy, to confirm the effectiveness and safety of this procedure. METHODS: We evaluated the 17 patients with idiopathic Parkinson's diesease who had undergone unilateral posteroventral pallidotomy. All patients responded to levodopa initially. Mean age was 55 years(38-75years), and mean duration of disease was 9.8 years(3-20years). Pre-and postoperative evaluation at 3 month intervals included Unified Parkinson's Disease Rating scale(UPDRS) scoring, Hoehn and Yahr(H and Y) staging, and neuropsychological examinations. RESULTS: Pallidotomy significantly improved parkinsonian symptom(tremor, rigidity, bradykinesia, dyskinesia, sensory symptom). Nine of 10 patients who showed dyskinesia preoperatively significant improvement. The mean dose of levodopa in 9 patients was lowered. The mean H and Y score and UPDRS score were improved in on and/or off time in 15 patients. Among patients who were not improved, one patient worsened, and the others showed no change. The mean overall UPDRS off score changed from 76 preoperatively to 44(33%) at 6 months and from 70 to 52(25%) at 1 year. Transient surgical morbidity was showen in four patients and included dysarthria, hypotonia and confusion. CONCLUSION: We conclude that pallidotomy is safe and effective in patients who have levodopa-reponsive parkinsonism with severe symptom fluctuation. Unilateral pallidotomy also considered helpful to ipsilateral symptom. Unilateral pallidotomy can improve all of parkinsonian's symptom and allow to reduce the levodopa medication. Most of patients show satisfactory results.
Drug Therapy
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Dysarthria
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Dyskinesias
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Humans
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Hypokinesia
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Levodopa
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Muscle Hypotonia
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Pallidotomy*
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Parkinson Disease
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Parkinsonian Disorders
9.ATP-sensitive potassium channels: novel potential roles in Parkinson's disease.
Jie ZENG ; Gang WANG ; Sheng-Di CHEN
Neuroscience Bulletin 2007;23(6):370-376
The ATP-sensitive potassium (K(ATP)) channels which extensively distribute in diverse tissues (e.g. vascular smooth muscle, cardiac cells, and pancreas) are well-established for characteristics like vasodilatation, myocardial protection against ischemia, and insulin secretion. The aim of this review is to get insight into the novel roles of K(ATP) channels in Parkinson's disease (PD), with consideration of the specificities K(ATP) channels in the central nervous system (CNS), such as the control of neuronal excitability, action potential, mitochondrial function and neurotransmitter release.
Humans
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KATP Channels
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drug effects
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physiology
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Mitochondria
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metabolism
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Parkinson Disease
;
metabolism
;
therapy