1.A case of HTLV-I associated myelopathy(HAM) in Korea.
Jae Hyeon PARK ; Byun In LEE ; Sae Il LEE ; Mitsuhiro OSAME
Yonsei Medical Journal 1991;32(2):190-194
We report the first Korean case of HTLV-I associated myelopathy (HAM), which was confirmed by Western blot assay of serum and cerebrospinal fluid. Interestingly, the proband's wife was a Japanese Korean who had lived in the endemic area of HAM, Kyushu. Japan, Investigations revealed significantly elevated anti HTLV-I antibody titers in the serum, but not in the CSF, suggesting that she was a carrier of HTLV-I. Considering that the patient had not had a previous blood transfusion, the most common route of HTLV-I, it is likely that the patient was infected by his wife through sexual intercourse. Although previous reports suggest that the transmission of HTLV-I is essentially from man to man or man to woman, our case suggests that woman to man transmission also occurs.
Adult
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Blotting, Western
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HTLV-I Antibodies/analysis
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Human
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Korea/epidemiology
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Male
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Paraparesis, Tropical Spastic/*epidemiology/immunology
2.The Seroepidemiologic Study for Human T-cell Lymphotropic Virus Type I(HTLV-I) Infection in Residents of Cheju-Do.
June Myung KIM ; Eung KIM ; Chang Hyun CHOI ; Suk Min KANG ; Won Chun KIM ; Tai Young YOON ; Jung Myung CHOI ; Sun Young PARK ; Dong Joon LEW
Korean Journal of Infectious Diseases 1997;29(3):171-181
BACKGROUND: Human T-cell lymphotropic virus type I (HTLV-I) is a retrovirus that has been identified as a cause of adult T-cell leukemia/lymphoma and tropical spastic paraparesis. HTLV-I infection is highly endemic in the southwestern islands of Japan, Caribbean basin, South America, and Africa. In 1993, we showed that the seroprevalence of antibodies to HTLV-I was 0.13% among blood donors in Korea, but surprisingly, 0.80% in Cheju-Do adjacent to endemic areas of Japan. So this study was designed to reevaluate the seroprevalence of antibodies to HTLV-I among residents in Cheju-Do. METHODS: Total 2,372 residents in Cheju-Do were tested from December 1995 to March 1996. Anti-HTLV-I antibodies were detected by the microtiter particle agglutination test. RESULTS: Among total 2,372 residents, 19 were anti-HTLV-I positive. So the overall positive rate of anti-HTLV-I antibodies was 0.80%. The positive rate in females was higher than in males (0.82% vs 0.78%). The positive rate was 1.45% in the age group of 20-29 years, 1.41% in 40-49 years, 0.91% in 0-9 years, 0.70% in 30-39 years, and 0.54% in 50-59 years. The mean age of seropositive cases is 35.2 in males and 35.4 in females, with a mean of 35.3. Geographically, high positive rate was observed in Sogwipo-City (1.37%) and Namcheju-Gun (0.83%) compared to those of Pukcheju-Gun (0.64%) and Cheju-City (0.61%), which showed high seroprevalence in districts adjacent to endemic areas of Japan. Any specific risk factors or associated disorders of HTLV-I infection could not be found among the seropositive cases. CONCLUSION: The seroprevalence of antibodies to HTLV-I in Cheju-Do was noted to be very high by the microtiter particle agglutination test. So henceforth serosurvey by confirmative laboratory tests is needed, and if high seroprevalence is showed from it, screening of blood donors for HTLV-I in Cheju-Do should be considered to prevent transfusion-associated HTLV-I infection.
Adult
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Africa
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Agglutination Tests
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Antibodies
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Blood Donors
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Caribbean Region
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Epidemiology
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Female
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HTLV-I Infections
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Human T-lymphotropic virus 1
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Humans*
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Islands
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Japan
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Jeju-do*
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Korea
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Male
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Mass Screening
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Paraparesis, Tropical Spastic
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Retroviridae
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Risk Factors
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Seroepidemiologic Studies*
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South America
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T-Lymphocytes*
3.Nucleotide sequence analysis of HTLV-I isolate from a Korean patient with HAM/TSP.
Mineki SAITO ; Takashi MORITOYO ; Jae Hyeon PARK ; Byung In LEE ; Jin Soo KIM ; Jun ichi FUJISAWA ; Mitsuhiro OSAME ; Mitsuaki YOSHIDA
Yonsei Medical Journal 1993;34(4):321-327
Limited nucleotide sequences of human T-cell lymphotropic virus type I (HTLV-1) provirus isolated from the first case of a Korean patient with HTLV-I associated myelopathy and tropical spastic paraparesis (HAM/TSP) were analysed and compared with other isolates from different regions of the world. The sequences of the env, LTR regions (536bp, 690bp respectively) showed 98.7%, 99.3% homologies with the prototype HTLV-I, ATK-1, isolated from a Japanese Adult T-cell leukemia (ATL) patient. A comparison between other isolates from different geographical origins revealed that the Korean HTLV-I isolate is more closely related to Japanese isolates than to those from other geographical origins
Adult
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Base Sequence
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Case Report
;
DNA, Viral/genetics
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Human
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Human T-lymphotropic virus 1/*genetics/isolation & purification
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Korea/ethnology
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Male
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Molecular Probes/genetics
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Molecular Sequence Data
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Paraparesis, Tropical
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Spastic/epidemiology/ethnology/*genetics/*microbiology