1.Thymoma associated with severe diarrhoea and anaemia.
Feng GE ; Ze-jian LI ; Zhi-li CAO
Chinese Medical Journal 2006;119(6):526-528
Adult
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Aged
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Anemia
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etiology
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Diarrhea
;
etiology
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Humans
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Male
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Paraneoplastic Syndromes
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etiology
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Thymoma
;
complications
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Thymus Neoplasms
;
complications
4.A Case of Uterine Cervical Cancer Presenting with Granulocytosis.
Heui June AHN ; Yeon Hee PARK ; Yoon Hwan CHANG ; Sun Hoo PARK ; Min Suk KIM ; Baek Yeol RYOO ; Sung Hyun YANG
The Korean Journal of Internal Medicine 2005;20(3):247-250
Granulocytosis occurs in 40% of patients with lung and gastrointestinal cancers, 20% of patients with breast cancer, 30% of patients with brain tumor and ovarian cancer and 10% of patients with renal cell carcinoma. Granulocytosis occurs because of production of G-CSF, GM-CSF and IL-6. Uterine cervical carcinoma with granulocytosis as a paraneoplastic syndrome, however, has been rarely reported. We recently witnessed a case of invasive squamous cell carcinoma of the uterine cervix with granulocytosis. Leukocytosis developed up to 69, 000/micro L, and then normalized after chemo-radiotherapy. There was no evidence of infection, tumor necrosis, glucocorticoid administration, or myeloproliferative disease by examination of a bone marrow aspirate when granulocytosis appeared. This phenomenon was probably associated with the secretion of hematopoietic growth factors such as G-CSF, GM-CSF and IL-6 by the tumor. We suggest that, like some other solid tumors, cervical cancer can present with granulocytosis as a paraneoplastic syndrome.
Uterine Neoplasms/complications/*diagnosis
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Uterine Cervical Neoplasms/complications/*diagnosis/physiopathology
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Paraneoplastic Syndromes/*etiology
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Middle Aged
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Leukocytosis/*etiology
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Humans
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Granulocytes/*pathology
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Female
5.Mechanism of alopecia in patients with paraneoplastic pemphigus.
Ya-gang ZUO ; Bao-xi WANG ; Dong-lai MA ; Bing-qing CAO ; Jing-hui ZHAO ; Ying GUO
Acta Academiae Medicinae Sinicae 2005;27(3):354-356
OBJECTIVETo investigate the relationship between the levels of antidesmoglein (DSG) 1, 3 antibodies in the sera of patients with paraneoplastic pemphigus (PNP) and alopecia.
METHODSSera from PNP patients, bullous pemphigoid patients, and normal healthy subjects were collected and 2 tissue samples from 2 healthy scalps were resected. Anti-DSG 1, 3 antibodies in the sera of PNP patients were detected by enzyme-linked immunosorbent assay (ELISA). Indirect immunofluorescent assay was used to detect whether the antibodies in the sera of PNP patients binds with the follicular epithelium of normal healthy scalp.
RESULTSAnti-DSG3 autoantibody was strongly positive and anti-DSG1 weakly positive in one patient, while both two antibodies were negative in the other patient. Their sera could bind to keratinocytes and follicular epithelium in human scalp. Immunofluorescent signals were found on the intercellular epidermal cell surface and outer root sheath of the follicular epithelium. However, the immunofluorescent signals in the section incubating with serum of bullous pemphigoid were only found on basal membrane zone. No signals were found in the section incubating with normal healthy serum.
CONCLUSIONAlopecia in PNP patients are correlated with the anti-DSG3.
Adult ; Alopecia ; etiology ; immunology ; Autoantibodies ; blood ; Desmoglein 1 ; immunology ; Desmoglein 3 ; immunology ; Female ; Humans ; Male ; Paraneoplastic Syndromes ; complications ; immunology ; Pemphigus ; complications ; immunology
6.Heart failure as the first manifestation of renal cell carcinoma.
Chee Meng LEE ; Allen SIM ; Gunasegaran KURUGULASIGAMONEY ; Lay Guat NG
Korean Journal of Urology 2015;56(1):82-85
We report the rare case of a patient with advanced renal cell carcinoma (RCC) who initially presented to the hospital with symptoms of cardiac failure. Preoperative cardiac studies did not reveal any underlying ischemia. After resection of a large 14-cm left renal tumor, cardiac function was noted to improve dramatically. We discuss this case of concomitant RCC and nonischemic cardiomyopathy.
Asian Continental Ancestry Group
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Carcinoma, Renal Cell/*diagnosis/surgery
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Cardiomyopathies/*diagnosis
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Female
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Heart Failure/*etiology
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Humans
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Middle Aged
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Paraneoplastic Syndromes/complications
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Thalassemia/complications
8.A case of membranoproliferative glomerulonephritis associated with metastatic colon cancer.
Jung Hwa RYU ; Soon Sup CHUNG ; Dong Ryeol RYU ; Seung Jung KIM ; Duk Hee KANG ; Sun Hee SUNG ; Kyu Bok CHOI
The Korean Journal of Internal Medicine 2013;28(2):254-257
No abstract available.
Adenocarcinoma/*secondary/surgery
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Chemotherapy, Adjuvant
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Colectomy
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Glomerulonephritis, Membranoproliferative/diagnosis/*etiology/therapy
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Hepatectomy
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Humans
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Liver Neoplasms/*secondary/surgery
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Male
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Middle Aged
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Paraneoplastic Syndromes/diagnosis/*etiology/therapy
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Renal Dialysis
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Renal Insufficiency/etiology
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Sigmoid Neoplasms/*pathology/surgery
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Treatment Outcome
9.Inflammatory Myofibroblastic Tumor on Intercostal Nerve Presenting as Paraneoplastic Pemphigus with Fatal Pulmonary Involvement.
Dong Hyun LEE ; Sun Ho LEE ; Joo Kyung SUNG
Journal of Korean Medical Science 2007;22(4):735-739
Inflammatory myofibroblastic tumors (IMTs) are benign neoplasms that can occur at different anatomic sites with nonspecific clinical symptoms. A 48-yr-old woman presented with a 2-month history of a relapsed oral ulcer, progressive dyspnea, and a thoracic pain induced by breathing. A tumorous mass was noticed in the right costodiaphragmatic recess on chest computed tomography and magnetic resonance imaging, and the patient underwent a right costotransversectomy with excision of the tumor, which originated from the 12th intercostal nerve. Histology and immunohistochemistry showed that the tumor was an IMT of the intercostal nerve. The patient's postoperative course was not favorable; dyspnea persisted after surgery, and a progressive pulmonary compromise developed. The cause of the respiratory failure was found to be bronchiolitis obliterans, which in this case proved to be a fatal complication of paraneoplastic pemphigus associated with an IMT. This case of IMT of the spinal nerve in the paravertebral region is unique in terms of its location and presentation in combination with paraneoplastic pemphigus, which is rare. A brief review of the heterogeneous theories concerning the pathogenesis, clinicopathological features, and differential diagnosis of this disease entity is presented.
Diagnosis, Differential
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Fatal Outcome
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Female
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Granuloma, Plasma Cell/complications/*pathology
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Humans
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Intercostal Nerves/*pathology
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Lung Diseases/etiology/pathology
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Middle Aged
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Paraneoplastic Syndromes/etiology/*pathology
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Pemphigus/etiology/*pathology
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Peripheral Nervous System Neoplasms/complications/*pathology
10.Malignant acanthosis nigricans in a patient with a gastrointestinal stromal tumor.
Keon Woo PARK ; Do Hyoung LIM ; Soon Il LEE
The Korean Journal of Internal Medicine 2013;28(5):632-633
No abstract available.
Acanthosis Nigricans/diagnosis/*etiology
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Biopsy
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Gastrointestinal Stromal Tumors/chemistry/*complications/pathology
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Humans
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Immunohistochemistry
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Laparoscopy
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Male
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Middle Aged
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Paraneoplastic Syndromes/diagnosis/*etiology
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Peritoneal Neoplasms/chemistry/*complications/pathology
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Proto-Oncogene Proteins c-kit/analysis
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Tomography, X-Ray Computed
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Tumor Markers, Biological/analysis