Study was carried out in 162 bronchial cancer patients (83 males, 75 females) in National Institute of Tuberculosis and Lung Diseases from November 1991 to October 1994. Paraneoplastic syndrome account for 51.8% including the symptoms of bone-articular and connective tissues, 43.6% hematology 22.8%, skin 6.8%, endocrino-metabolism 3.1% and kidney 0.6%. Paraneoplastic syndromes of bone-articular connective tissue, include pain manifestations of bones and joints, finger clubbed, symptoms of hematology: anemia, neutrophilia, eosiniphilia and polyplastocytosis; symptoms of skin: hypertrichosis, keratodermia, chloasma cutaneous dystrophy in two feet, vascularmotrice disturbance of inferior limbs; symptoms endocrino-metabolism: hyperuricemia, inaddition, there are some manifestations on kidney and chronical glomerulo-nephritis
Paraneoplastic Syndromes ; Bronchial Neoplasms ; Diseases ; diagnosis ; Therapeutics

Encephalitis ; diagnosis ; pathology ; Humans ; Lymphoma ; diagnosis ; pathology ; Male ; Middle Aged ; Paraneoplastic Syndromes ; diagnosis ; pathology

Aged ; Colonic Neoplasms ; diagnosis ; Humans ; Male ; Paraneoplastic Syndromes ; diagnosis ; Pemphigus ; diagnosis

Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Motor Neuron Disease ; diagnosis ; Paraneoplastic Syndromes, Nervous System ; diagnosis

PURPOSE: Recent advances and wider application of imaging diagnostic techniques, especially ultrasonography(USG) and computed tomography(CT), account for the increasing incidentaloma in adrenal and renal tumors. We have studied these incidentalomas to investigate the incidences, occasions of detection, pathological findings, prognosis and other clinical properties. MATERIALS AND METHODS: The 186 cases of adrenal and renal tumors, treated surgically in Kyoungpook National University Hospital between 1987 and 1997 were reviewed and compared incidentally detected group(59cases) to symptomatically suspected group(127cases). RESULTS: The analysis of 186 cases demonstrated a marked increase in the frequency of incidentaloma from 15.6%(1987?1992) to 43.1%(1993?1997). The proportions of incidentaloma in adrenal and renal tumors were 20.4% in adrenal tumor, 36.4% in renal tumor and 31.7% in total. The chief method of detection was USG(57.6%), followed by CT(33.9%) and IVP(6.8%). The main reasons for examination leading to the diagnosis in incidentaloma were evaluation of unrelated symptoms(44.1%), follow up of other diseases(35.6%), general health check(18.6%) and during other operation(1.7%). In case of adrenal incidentaloma, the mean tumor diameter was larger than in suspected group(4.8+/-3.4cm vs 3.1+/-2.3cm). The main histologic diagnosis of adrenal incidentaloma was adrenal adenoma and hormonally functional tumors were less than suspected group (63.6% vs 88.4%). In case of renal incidentaloma, the mean tumor diameter was smaller than in suspected group(5.3+/-2.1cm vs 8.7+/-2.2cm) and paraneoplastic syndromes were less than in suspected group(20.8% vs 57.1%). The grade and stage of renal incidentaloma were lower and survival rate was higher than suspected group(5 year survival rate, 83.3% vs 64.3%). CONCLUSIONS: These results indicated that abdominal USG or CT should be performed with special attention to adrenal and renal lesions, where at a health examination or evaluation to unrelated disease.
Adenoma ; Carcinoma, Renal Cell ; Diagnosis ; Follow-Up Studies ; Incidence ; Paraneoplastic Syndromes ; Prognosis ; Survival Rate

Although, renal carcinoma represent 2 to 3% of all human cancers, the impredictable nature, and unique clinical and biological features of renal carcinoma place it among the most interesting of human malignancies. Total surgical excisions offers the only certain cure for nephrocarcinoma, but additional benefit may be achieved by utilization of adjuvantive methods including surgical excision of metastasis, radiation, chemotherapy, and immunotherapy. So, 28 patients with renal cell carcinoma were analyzed retrospectively in order to 1) determine the effectiveness of systemic chemotherapy-hormonal and non-hormonal, 2) identify the clinical features of renal cell carcinoma that may be important in prognosis and 3) characterize the paraneoplastic features of renal cell carcinoma. The classic triad of signs and symptoms including pain, hematuria, and palpable tumor mass presents in only 7%. Paraneoplastic syndrome occurred in up to 28.6% Metastasis was present at diagnosis in 25 % of the cases and developed within 1 year in an additional 10.7%. Surgery was employed to 23 patients for the purpose of complete cure of the disease or palliation and adjuvantive therapy was employed either to palliate symptoms or to attempt eradication of metastatic deposits to 9 patients with or without surgery. Most of metastatic disease was unresponsive objectively to either primary nephrectomy or to a variety of chemotherapy trial. Improving diagnostic capabilities and the introduction of more sophisticated diagnostic equipment promise to provide still earlier identification of patients with renal cell carcinoma and to allow surgical intervention at curable stages of disease.
Carcinoma, Renal Cell* ; Diagnosis ; Diagnostic Equipment ; Drug Therapy ; Hematuria ; Humans ; Immunotherapy ; Neoplasm Metastasis ; Nephrectomy ; Paraneoplastic Syndromes ; Prognosis ; Retrospective Studies

A paraneoplastic syndrome is a disease or symptom that is the consequence of the presence of cancer in the body but is not due to the local presence of cancer cells. Thus, successful treatment of the underlying tumor often improves such syndromes. Amylase-producing lung cancer, multiple myeloma, and ovarian cancer are reported only rarely. In Korea, no cases of hyperamylasemia have been reported in patients with primary peritoneal carcinoma. We report an interesting case of hyperamylasemia suspected to have been induced by primary peritoneal carcinoma. The patient's amylase isoenzyme patterns indicated salivary-type amylase. Hyperamylasemia was reduced in parallel with the response to chemotherapy. These data confirmed the diagnosis of amylase-producing primary peritoneal carcinoma.
Amylases ; Diagnosis ; Drug Therapy ; Humans ; Hyperamylasemia ; Korea ; Lung Neoplasms ; Multiple Myeloma ; Ovarian Neoplasms ; Paraneoplastic Syndromes ; Peritoneal Neoplasms

The paraneoplastic nephrotic syndrome can be diagnosed by clinical and immunologic features. We have had a case of paraneoplastic nephrotic syndrome in the patients with aadeno-carcinoma of the lung, whose diagnosis was made by excluding other causes of nephrotic syndrome. The type of renal lesion was membranous glomerulopathy which commonly occurs in carcinoma. The quantity of proteinuria in this patient had decreased according to the improvement of lung cancer with combination chemotherapy. After fourth chemotherapy he was refractory to treatment, and unfortunately he had passed away with cardiac tamponade.
Adenocarcinoma* ; Cardiac Tamponade ; Diagnosis ; Drug Therapy ; Drug Therapy, Combination ; Glomerulonephritis, Membranous* ; Humans ; Lung Neoplasms ; Lung* ; Nephrotic Syndrome ; Paraneoplastic Syndromes ; Proteinuria

The nephrotic syndrome that occurs in the absence of renal vein thrombosis, amyloidosis, neoplastic infiltration of the kidneys is an unusual but a well recognized paraneoplastic syndrome. The most frequently reported neoplasms associated with nephrotic syndrome are Hodgkin's disease and various carcinomas. The most common renal lesions are membranous glomerulonephritis(MGN) associated with carcinomas and minimal change lesions associated with Hodgkin's disease. Approximately 40% to 45% of patients clinically manifest the MGN symptoms prior to the diagnosis of the tumor, 40% simultaneously with the tumor and the remaining 15% to 20% following the tumor. Therefore, evaluating the underlying malignancy in patients with MGN is important. Here we report a patient with squamous cell lung cancer, which was detected 12 months after a MGN had been diagnosed, with a review of the relevant literature.
Amyloidosis ; Diagnosis ; Glomerulonephritis, Membranous* ; Hodgkin Disease ; Humans ; Kidney ; Lung Neoplasms* ; Lung* ; Nephrotic Syndrome ; Paraneoplastic Syndromes ; Renal Veins ; Thrombosis

BACKGROUND/AIMS: Patients with hepatocellular carcinoma (HCC) may manifest paraneoplastic syndromes such as hypercholesterolemia, hypoglycemia, hypercalcemia and erythrocytosis. This study was aimed at evaluating the incidence and clinical significance of paraneoplastic syndromes in Korean HCC patients. METHODS: The medical records of 165 HCC patients who were diagnosed and died in the Kyung Hee University Hospital, were reviewed retrospectively. The following variables were analyzed: age, gender, hepatitis markers, platelet, liver function test, alpha-fetoprotein (AFP), Child-Pugh score, tumor features, and the duration of their survival. RESULTS: In total, paraneoplastic syndromes were presented in 43.6% of the HCC patients during the course of their disease. Hypercholesterolemia was solely presented in 14.5%, hypoglycemia in 12.7% and hypercalcemia in 7.8%. The patients who presented with more than 2 syndromes were 8.5%. While 80% of erythrocytosis (4/5) and 51.6% of hypercholesterolemia (16/31) was presented at the time of HCC diagnosis, hypoglycemia and hypercalcemia mainly occurred as terminal events. The patients with paraneoplastic syndromes were younger and had higher rates of portal vein thrombosis, bi-lobar tumor involvement and tumor more of more than 10 cm in diameter, compared to those patients without them. The proportion of patients with a serum AFP more than 400 ng/mL tended to be higher in the patients with paraneoplastic syndromes. The HCC patients with paraneoplastic syndromes, except for erythrocytosis, had a shorter survival than those patients without them. CONCLUSIONS: Paraneoplastic syndromes are not infrequently presented in HCC patients, especially at an advanced stage, and the survival of these patients is relatively shorter.
Aged ; Carcinoma, Hepatocellular/*complications/mortality ; English Abstract ; Female ; Humans ; Liver Neoplasms/*complications/mortality ; Male ; Middle Aged ; Paraneoplastic Syndromes/complications/diagnosis