No abstract available.
Limbic Encephalitis* ; Paraneoplastic Syndromes

Paraneoplastic pemphigus (PNP) is an autoimmune blistering skin disease associated with neoplasms. Clinically, it is characterized by severe mucosal erosions and various cutaneous lesions. Suprabasal acantholysis and cleft with scattered necrotic keratinocytes are the unique histopathological features of PNP. The pathogenic autoantibodies existed in PNP sera, and their production was correlated with the associated tumor. Early detection and resection of the tumor are essential for the treatment of the disease.
Humans ; Paraneoplastic Syndromes ; Pemphigus

Germ cell tumor is the most prevalent ovarian tumor in young women between 10 and 30 years of age.[1] However, immature teratomas account for only 20% of the malignant ovarian tumors found in the adolescent age group.[2] More uncommon is the occurrence of immature teratoma causing anti‑N‑methyl‑D‑aspartate receptor (Anti‑NMDAR) encephalitis and Guillain‑Barré Syndrome (GBS). This is a case of a 15‑year‑old female, nulligravid, who initially presented sudden behavioral change and symmetrical weakness of both lower and upper extremities with concomitant seizure episodes and with palpable lower abdominal mass. The patient was diagnosed to have GBS and treated with intravenous immunoglobulin causing resolution of neurologic symptoms months after. During the management of GBS, the patient noted increasing abdominal girth. Tumor markers showed elevated alpha‑fetoprotein, CA125, and lactate dehydrogenase. An imaging study revealed predominantly solid ovarian mass hence malignancy was considered. Once the medical condition stabilized, the patient underwent fertility‑sparing surgery with the final histopathologic result of immature teratoma. The aim of this report is to present a case of anti‑NMDAR encephalitis and GBS as paraneoplastic manifestation of immature teratoma.
Encephalitis ; Paraneoplastic Syndromes

No abstract available.
Dexamethasone ; Paraneoplastic Syndromes, Ocular ; Plasma

Background: Paraneoplastic syndrome is a rare syndrome on lung cancer patients in Vietnam and in the world. Objective: To define the percentage of the common paraneoplastic syndromes on lung cancer patients and research the clinical and investigations of these syndromes. Subjects and method: A study included 570 patients diagnosed lung cancer based on histopathological and cytological evidences, treated in Department of Respiratory in Bach Mai Hospital from 2003 to 2005. This was a descriptive, retrospective study. Results and conclusions: 19.47% of the patients had common paraneoplastic syndromes. Pierre Marie's syndrome was the most common (65.8%), followed by Schwartz-Bartter's syndrome (25.2%). 64.8% of the patients were 50 to 69 years old, 88.3% were men, 83.8% were smokers. 66.6% of patients were the severe periods. 30.7% of patients were diagnosed histologically adenocarcinoma. 12.8% of patients had Pierre Marie's syndrome, 5.3% had Schwartz-Bartter's syndrome, 1.9% had hypercalcemia of malignancy and 1.9% had thromboembolism.
Lung Neoplasms/ pathology ; Paraneoplastic Syndromes/ pathology

Study was carried out in 162 bronchial cancer patients (83 males, 75 females) in National Institute of Tuberculosis and Lung Diseases from November 1991 to October 1994. Paraneoplastic syndrome account for 51.8% including the symptoms of bone-articular and connective tissues, 43.6% hematology 22.8%, skin 6.8%, endocrino-metabolism 3.1% and kidney 0.6%. Paraneoplastic syndromes of bone-articular connective tissue, include pain manifestations of bones and joints, finger clubbed, symptoms of hematology: anemia, neutrophilia, eosiniphilia and polyplastocytosis; symptoms of skin: hypertrichosis, keratodermia, chloasma cutaneous dystrophy in two feet, vascularmotrice disturbance of inferior limbs; symptoms endocrino-metabolism: hyperuricemia, inaddition, there are some manifestations on kidney and chronical glomerulo-nephritis
Paraneoplastic Syndromes ; Bronchial Neoplasms ; Diseases ; diagnosis ; Therapeutics

Renal cell carcinoma constitutes approximately 2% of all new malignancies and accounts for majority of all primary renal malignant tumors. Because of its bizarre clinical and biologic behaviors, renal cell carcinoma is one of the most interesting malignant tumors. Many paraneoplastic syndromes associated with renal cell carcinoma are known to return to normal following removal of primary lesion. We report a case of renal cell carcinoma with hyperglycemia corrected after radical nephrectomy.
Carcinoma, Renal Cell* ; Hyperglycemia* ; Nephrectomy* ; Paraneoplastic Syndromes

Head and Neck Neoplasms ; Humans ; Paraneoplastic Syndromes

No abstract available.
Chorea ; Paraneoplastic Syndromes ; Small Cell Lung Carcinoma

Sensory neuropathy is characterized by pure sensory dysfunction, ultimately evolving into areflexia and severe sensory ataxia in spite of the preservation of the other functions in the nervous system such as motor function. This disorder is known to be commonly found in cancer patients as a paraneoplastic syndrome, but nowadays many reports are made that sensory neuropathy is not merely related to malignancy but also with autoimmune disorders such as Sjogren's syndrome or polyclonal gammopathy, etc. Hence we report two patients who have been diagnosed as chronic idiopathic ataxic sensory neuropathy through electrophysiological and histopathological studies without any evidence of cancer or any other known cause.
Ataxia ; Humans ; Nervous System ; Paraneoplastic Syndromes ; Sjogren's Syndrome