1.A Case of Ectopic Adrenocorticotropic Hormone Syndrome in Small Cell Lung Cancer.
Chaiho JEONG ; Jinhee LEE ; Seongyul RYU ; Hwa Young LEE ; Ah Young SHIN ; Ju Sang KIM ; Joong Hyun AHN ; Hye Seon KANG
Tuberculosis and Respiratory Diseases 2015;78(4):436-439
Small cell lung cancer (SCLC), which originated from neuroendocrine tissue, can develop into paraneoplastic endocrine syndromes, such as Cushing syndrome, because of an inappropriate secretion of ectopic adrenocorticotropic hormone (ACTH). This paraneoplastic syndrome is known to be a poor prognostic factor in SCLC. The reason for poor survival may be because of a higher risk of infection associated with hypercortisolemia. Therefore, early detection and appropriate treatment for this syndrome is necessary. But the diagnosis is challenging and the source of ACTH production can be difficult to identify. We report a 69-year-old male patient who had severe hypokalemia, metabolic alkalosis, and hypertension as manifestations of an ACTH-secreting small cell carcinoma of the lung. He was treated with ketoconazole and spironolactone to control the ACTH dependent Cushing syndrome. He survived for 15 months after chemotherapy, which is unusual considering the poor outcome of the ectopic ATH syndrome associated with SCLC.
ACTH Syndrome, Ectopic
;
Adrenocorticotropic Hormone*
;
Aged
;
Alkalosis
;
Carcinoma, Small Cell
;
Cushing Syndrome
;
Diagnosis
;
Drug Therapy
;
Humans
;
Hypertension
;
Hypokalemia
;
Ketoconazole
;
Lung
;
Male
;
Paraneoplastic Endocrine Syndromes
;
Paraneoplastic Syndromes
;
Small Cell Lung Carcinoma*
;
Spironolactone
2.Anti-Ri-Antibody-Associated Paraneoplastic Syndrome in a Man with Breast Cancer Showing a Reversible Pontine Lesion on MRI.
Heeyoung KIM ; Youngmin LIM ; Kwang Kuk KIM
Journal of Clinical Neurology 2009;5(3):151-152
BACKGROUND: Paraneoplastic neurological disorders associated with anti-Ri-antibodies, which are typically present with opsoclonus-myoclonus-ataxia. Most cases with anti-Ri-antibodyassociated paraneoplastic syndrome due to breast cancer occur in women - its occurrence in men is extremely rare. CASE REPORT: We present herein the case of a male patient with breast cancer who had atypical anti-Ri-antibody-associated paraneoplastic syndrome presenting as complete horizontal ophthalmoplegia, left trigeminal sensory symptoms, and truncal ataxia. Following the diagnosis of paraneoplastic syndrome, chemotherapy and immunomodulating treatment including intravenous immunoglobulin and oral prednisolone were administered. Although the patient was negative for serum anti-Ri-antibodies 14 weeks later, his symptoms persisted. CONCLUSIONS: To our knowledge, this is the first case report of ophthalmoplegia without opsoclonus-myoclonus in a male anti-Ri-antibody-positive patient with breast cancer.
Ataxia
;
Breast
;
Breast Neoplasms
;
Female
;
Humans
;
Immunoglobulins
;
Male
;
Multiple Endocrine Neoplasia Type 1
;
Nervous System Diseases
;
Ophthalmoplegia
;
Paraneoplastic Syndromes
;
Prednisolone
3.A case of nasopharyngeal carcinoma accompanying erythroderma.
Feng LIN ; Qingfeng LIN ; Xiangdong LU
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2013;27(3):162-163
We describe a 58-years-old man with a primary nasopharyngeal carcinoma accompanying erythroderma. His first symptoms were systemic scattered erythema and itching for six months. Lower right cervical lymphadenectasis was found by physical examination. A neoplasm in nasopharynx could be seen with nasal endoscope. The pathology of the neoplasm was non-keratinizing carcinoma. This case illustrates that "erythroderma" could be a paraneoplastic effect of nasopharyngeal carcinoma.
Carcinoma
;
Dermatitis, Exfoliative
;
complications
;
Humans
;
Male
;
Middle Aged
;
Nasopharyngeal Carcinoma
;
Nasopharyngeal Neoplasms
;
complications
;
Paraneoplastic Endocrine Syndromes
;
complications
4.Syndrome of inappropriate antidiuretic hormone secretion following irinotecan-cisplatin administration as a treatment for recurrent ovarian clear cell carcinoma.
Do Youn KWON ; Gwan Hee HAN ; Roshani ULAK ; Kyung Do KI ; Jong Min LEE ; Seon Kyung LEE
Obstetrics & Gynecology Science 2017;60(1):115-117
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) has various causes including central nervous system disorders, pulmonary and endocrine diseases, paraneoplastic syndromes, and use of certain drugs. SIADH induced by chemotherapy with irinotecan-cisplatin is not a common complication. Here, we review a case of SIADH after treatment with irinotecan-cisplatin. A 45-year-old woman received adjuvant chemotherapy (paclitaxel-carboplatin) for ovarian clear cell carcinoma, but the cancer recurred within 9 months of chemotherapy. Subsequently, a second line of combination chemotherapy containing irinotecan-cisplatin was initiated. However, 5 days after chemotherapy administration, her general condition began to deteriorate; her hematological tests revealed hyponatremia. Therefore, it is imperative to consider the possibility of SIADH in patients being treated with irinotecan-cisplatin–based chemotherapy. Proper monitoring of serum sodium levels and assessment of clinical symptoms should be performed in such patients for early diagnosis and prompt management.
Central Nervous System Diseases
;
Chemotherapy, Adjuvant
;
Cisplatin
;
Drug Therapy
;
Drug Therapy, Combination
;
Early Diagnosis
;
Endocrine System Diseases
;
Female
;
Hematologic Tests
;
Humans
;
Hyponatremia
;
Inappropriate ADH Syndrome
;
Middle Aged
;
Paraneoplastic Syndromes
;
Sodium
5.Zollinger-Ellison Syndrome: A Case Report.
Dong Jin JUNG ; Hyun Kwon HA ; Pyo Nyun KIM ; Moon Gyu LEE ; Yong Ho AUH
Journal of the Korean Radiological Society 1999;41(6):1173-1176
Zollinger-Ellison syndrome (ZES) involves hypergastinemia produced by a gastrin-secreting tumor. Not only can it cause an ulcer but may also behave as a malignant lesion, metastasizing to the liver or other organs. The development of potent antisecretory agents for controlling acid secretion as well as techniques for localizing these islet cell tumors, has led to greatly improved survival rates. We describe a case of Zollinger-Ellison syndrome, emphasising the radiologic findings, and including a review of the literature.
Adenoma, Islet Cell
;
Liver
;
Survival Rate
;
Ulcer
;
Zollinger-Ellison Syndrome*
6.A Case of Zollinger-Ellison Syndrome with Gastrinoma Localized by 111In-Pentetreotide Scan.
Hyeon Jo JEONG ; Jin Sook RYU ; Jae Seung KIM ; Dae Hyuk MOON ; Hwoon Yong JUNG ; Hyun Kwon HA ; Hee Kyung LEE
Korean Journal of Nuclear Medicine 1999;33(6):537-542
In patient with Zollinger-Ellison syndrome, it is difficult to localize gastrinoma because the tumor is frequently small and multiple. However, accurate localization of the tumor is important for the treatment. Among various imaging modalities, somatostatin receptor scintigraphy (SRS) has been recognized to be the most sensitive tool for the detection of neuroendocrine tumors such as gastrinomas based on the presence of high-affinity binding sites for somatostatin. Recently, we experienced a case of Zollinger-Ellison syndrome caused by gastrinomas which was localized by SRS. This is the first case report of gastrinoma detected by SRS in Korea. SRS can facilitate tumor detection in patient with Zollinger-Ellison syndrome and should be considered as the first-line diagnostic method in the early course of the disease.
Binding Sites
;
Gastrinoma*
;
Humans
;
Korea
;
Neuroendocrine Tumors
;
Radionuclide Imaging
;
Receptors, Somatostatin
;
Somatostatin
;
Zollinger-Ellison Syndrome*
7.Atypical Thymic Carcinoid in a Patient with Zollinger-Ellison Syndrome
Jiyun LEE ; Kwanyong HYUN ; Mi Hyoung MOON ; Seok Whan MOON ; Jae Kil PARK ; Si Young CHOI ; Young Jo SA ; Kyung Soo KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 2019;52(6):420-424
Atypical thymic carcinoid is an extremely rare tumor with a poor prognosis. In addition to its known association with multiple endocrine neoplasia type 1, its hallmark characteristics include local invasion and early distant metastasis. In this report, we share our experience treating atypical thymic carcinoid in a patient with Zollinger-Ellison syndrome.
Carcinoid Tumor
;
Humans
;
Multiple Endocrine Neoplasia Type 1
;
Neoplasm Metastasis
;
Neuroendocrine Tumors
;
Prognosis
;
Zollinger-Ellison Syndrome
8.A Case of Multiple Gastric Carcinoids Associated with Chronic Atrophic Gastritis and Hypergastrinemia.
Myoung Kuk JANG ; Gin Hyug LEE ; Sung Sook LEE ; Chan Sun PARK ; Jeong Sik BYEON ; Yun Jung LEE ; Seung Jae MYUNG ; Hwoon Yong JUNG ; Suk Kyun YANG ; Weon Seon HONG ; Jin Ho KIM ; Young Il MIN ; Jung Sun KIM
Korean Journal of Gastrointestinal Endoscopy 2003;27(2):70-75
Gastric carcinoid tumors are so rare that they constitute less than 1% of total primary gastric tumors. They are classified into 3 types: (1) gastric carcionoid associated with chronic atrophic gastritis (type I), (2) gastric carcinoids associated with Zollinger-Ellison syndrome (ZES) or multiple endocrine neoplasm (MEN) type 1 (type II), and (3) sporadic gastric carcinoid (type III). A 55-year-old man underwent a medical check-up. Five polypoid masses were incidentally detected in the cardia, fundus and midbody whose size ranged from 0.5 cm to 1.6 cm in diameter. Tumor cells were strongly positive for cytokeratin, synaptophysin and chromogranin staining. Biopsies from the body and fundus showed severe atrophy. Fasting serum gastrin level was highly increased, 1,098 pg/mL. There was, however, no evidence of the presence of ZES or MEN type 1. The patient underwent total gastrectomy for complete resection and has remained free of any complications with normal serum gastrin level.
Atrophy
;
Biopsy
;
Carcinoid Tumor*
;
Cardia
;
Fasting
;
Gastrectomy
;
Gastrins
;
Gastritis, Atrophic*
;
Humans
;
Keratins
;
Male
;
Middle Aged
;
Synaptophysin
;
Zollinger-Ellison Syndrome
9.A Case of Endoscopic Treatment of Multiple Carcinoid Tumors in Stomach.
Sang Wook CHO ; Jun Ki KIM ; Seong Ha SHIN ; Young Chun GO ; Jeong Young CHOI ; Myung Weon KANG ; Yuen Keun LIM ; Hyang Soon YEO ; Kyung Soo KIM
Korean Journal of Gastrointestinal Endoscopy 2001;22(1):36-40
Multiple carcinoid tumors in stomach are very rare tumors and associated with pernicious anemia, chronic atrophic gastritis and Zollinger-Ellison syndrome. These are believed to be due to hypergastrinemia, resulting in chronic stimulation of enterochromaffine-like (ECL) cells, leading to hyperplasia, metaplasia and ultimately neoplasia. The carcinoid tumor is potentially malignant, even though it may grow slowly, so the treatment of choice must be endoscopic lumpectomy or surgical gastrectomy. The prognosis depends on the site of the tumor and its size. Most carcinoid tumors are less than 1 cm in size and metastasis is uncommon but metastasis in tumors with size over 2 cm is common. A case of multiple carcinoid tumors in stomach, which was successfully removed by endoscopy, is herein reported.
Anemia, Pernicious
;
Carcinoid Tumor*
;
Endoscopy
;
Gastrectomy
;
Gastrins
;
Gastritis, Atrophic
;
Hyperplasia
;
Mastectomy, Segmental
;
Metaplasia
;
Neoplasm Metastasis
;
Prognosis
;
Stomach*
;
Zollinger-Ellison Syndrome
10.Synchronous Peripancreatic Lymph Node Gastrinoma and Gastric Neuroendocrine Tumor Type 2.
Hee Woo LEE ; Jun Won CHUNG ; Yoon Jae KIM ; Kwang Ahn KWON ; Eui Joo KIM ; Keon Kuk KIM ; Woon Ki LEE ; Sun Jin SYM
Clinical Endoscopy 2016;49(5):483-487
A 34-year-old man was referred to our hospital with gastric polypoid lesions and biopsy-confirmed neuroendocrine tumor (NET). Computed tomography (CT) revealed a 3×3.5×8-cm retroperitoneal mass behind the pancreas, with multiple hepatic metastases. His serum gastrin level was elevated to 1,396 pg/mL. We performed a wedge resection of the stomach, a right hemi-hepatectomy, and a retroperitoneal mass excision. After careful review of the clinical, radiological, histopathological, and immunohistochemical findings, peripancreatic gastrinoma, and synchronous gastric NET were ultimately diagnosed. We reviewed a CT scan that had been performed 6 years previously after surgery for a duodenal perforation. There was no evidence of gastric or hepatic lesions, but the retroperitoneal mass was present at the same site. Had gastrinoma been detected earlier, our patient could have been cured using less invasive treatment. This case demonstrates how important it is to consider Zollinger-Ellison syndrome in patients with a recurrent or aggressive ulcer.
Adult
;
Gastrinoma*
;
Gastrins
;
Humans
;
Lymph Nodes*
;
Neoplasm Metastasis
;
Neuroendocrine Tumors*
;
Pancreas
;
Stomach
;
Tomography, X-Ray Computed
;
Ulcer
;
Zollinger-Ellison Syndrome