1.DNA flow cytometry in pheochromocytoma and paraganglioma.
Woo Hee JUNG ; Woo Ick YANG ; Chanil PARK ; In Joon CHOI
Yonsei Medical Journal 1992;33(3):249-257
Flow cytometric DNA analysis was performed on 19 adrenal pheochromocytomas and 6 extra-adrenal paragangliomas in parallel with clinical and histopathological review to determine the usefulness of this technique to predict biologic behavior of these tumors. In pheochromocytomas and paragangliomas, tetraploidy or near-tetraploidy occurred in 32% and 33% and aneuploidy in 10% and none respectively. A case of malignant pheochromocytoma had diploid DNA content. Occurrence of aneuploidy or tetraploidy is frequent in clinically benign tumors in conjunction with a marked degree of nuclear atypia and cannot be a predictor of malignancy.
Adolescent
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Adrenal Gland Neoplasms/*genetics/pathology
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Adult
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Age Factors
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Child
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DNA, Neoplasm/*analysis
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Female
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*Flow Cytometry
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Human
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Male
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Middle Age
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Mitosis
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Paraganglioma/*genetics/pathology
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Pheochromocytoma/*genetics/pathology
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Ploidies
2.Clinicopathological features and molecular genetic analysis of endolymphatic sac tumor: report of 2 cases.
Qiu RAO ; Xiao-jun ZHOU ; Xing-zao JIN ; Heng-hui MA ; Hang-bo ZHOU ; Zhen-feng LU
Chinese Journal of Pathology 2010;39(6):412-413
Adenoma
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metabolism
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pathology
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Adult
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Carcinoma, Renal Cell
;
metabolism
;
pathology
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Diagnosis, Differential
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Ear Neoplasms
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complications
;
genetics
;
metabolism
;
pathology
;
surgery
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Endolymphatic Sac
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Female
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Follow-Up Studies
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Humans
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Kidney Neoplasms
;
metabolism
;
pathology
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Middle Aged
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Paraganglioma
;
metabolism
;
pathology
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Point Mutation
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Von Hippel-Lindau Tumor Suppressor Protein
;
genetics
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von Hippel-Lindau Disease
;
complications
;
genetics
;
metabolism