1.Development of the Korea-Polyenvironmental Risk Score for Psychosis
Eun-Jin JEON ; Shi-Hyun KANG ; Yan-Hong PIAO ; Sung-Wan KIM ; Jung-Jin KIM ; Bong-Ju LEE ; Je-Chun YU ; Kyu-Young LEE ; Seung-Hee WON ; Seung-Hwan LEE ; Seung-Hyun KIM ; Eui-Tae KIM ; Clara Tammy KIM ; Dominic OLIVER ; Paolo FUSAR-POLI ; Fatima Zahra RAMI ; Young-Chul CHUNG
Psychiatry Investigation 2022;19(3):197-206
Objective:
Comprehensive understanding of polyenvironmental risk factors for the development of psychosis is important. Based on a review of related evidence, we developed the Korea Polyenvironmental Risk Score (K-PERS) for psychosis. We investigated whether the K-PERS can differentiate patients with schizophrenia spectrum disorders (SSDs) from healthy controls (HCs).
Methods:
We reviewed existing tools for measuring polyenvironmental risk factors for psychosis, including the Maudsley Environmental Risk Score (ERS), polyenviromic risk score (PERS), and Psychosis Polyrisk Score (PPS). Using odds ratios and relative risks for Western studies and the “population proportion” (PP) of risk factors for Korean data, we developed the K-PERS, and compared the scores thereon between patients with SSDs and HCs. In addition, correlation was performed between the K-PERS and Positive and Negative Syndrome Scale (PANSS).
Results:
We first constructed the “K-PERS-I,” comprising five factors based on the PPS, and then the “K-PERS-II” comprising six factors based on the ERS. The instruments accurately predicted participants’ status (case vs. control). In addition, the K-PERS-I and -II scores exhibited significant negative correlations with the negative symptom factor score of the PANSS.
Conclusion
The K-PERS is the first comprehensive tool developed based on PP data obtained from Korean studies that measures polyenvironmental risk factors for psychosis. Using pilot data, the K-PERS predicted patient status (SSD vs. HC). Further research is warranted to examine the relationship of K-PERS scores with clinical outcomes of psychosis and schizophrenia.
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