1.Pathology of Chronic Pancreatitis.
Korean Journal of Hepato-Biliary-Pancreatic Surgery 2003;7(2):169-176
No abstract available.
Pancreatitis, Chronic*
;
Pathology*
2.The Protective Role of Endoscopic Sphincterotomy and/or Cholecystectomy for Recurrence of Acute Biliary Pancreatitis.
The Korean Journal of Gastroenterology 2015;65(5):265-267
No abstract available.
Female
;
Humans
;
Male
;
Pancreatitis/*pathology
3.Non-alcoholic duct-destructive chronic pancreatitis: recognition before definitive treatment.
Jun Pyo CHUNG ; Sang Kyu NA ; Young Nyun PARK ; Jeong Sik YU ; Dong Sup YOON ; Se Joon LEE ; Si Young SONG ; Kwan Sik LEE ; Jae Bock CHUNG ; Sang In LEE ; Jin Kyung KANG
Yonsei Medical Journal 1999;40(5):518-522
Non-alcoholic duct-destructive chronic pancreatitis is a new entity that differs morphologically and pathogenetically from alcoholic chronic pancreatitis. Some clinical and imaging features of this entity resemble those of pancreatic cancer, and hence most of the reported cases underwent pancreatic resections including an invasive pancreaticoduodenectomy. Recognition of this new entity before a definitive treatment is therefore important to avoid an unnecessary pancreatic resection. Recently, we experienced a case of non-alcoholic duct-destructive chronic pancreatitis in an 80-year-old man presenting with obstructive jaundice and whose radiologic features were characteristic as originally described. Recognition of this new entity before definitive treatment enabled us to manage this patient optimally. In addition, the relation between non-alcoholic duct-destructive chronic pancreatitis and chronic pancreatitis with diffuse irregular narrowing of the main pancreatic duct is discussed.
Aged
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Aged, 80 and over
;
Case Report
;
Chronic Disease
;
Human
;
Male
;
Pancreatitis/pathology
;
Pancreatitis/diagnosis*
5.Multifocal IgG4-related Autoimmune Pancreatitis:Report of One Case.
Wan Ling DENG ; Juan LI ; Liang ZHU ; Ming HE ; Hua Dan XUE ; Zheng Yu JIN
Acta Academiae Medicinae Sinicae 2019;41(4):575-578
Autoimmune pancreatitis(AIP)is radiologically characterized by sausage-like diffuse swelling of the pancreatic parenchyma but may also be found as a localized mass that is easily misdiagnosed as a pancreatic neoplasm.AIP presenting as multifocal masses is rare.Here we report a case of multifocal IgG4-related AIP,in which the lesions grew in size and finally fused to become radiologically typical.
Humans
;
Immunoglobulin G4-Related Disease
;
diagnosis
;
pathology
;
Pancreas
;
pathology
;
Pancreatic Neoplasms
;
Pancreatitis
;
diagnosis
;
pathology
7.Primary hyperparathyroidism presenting as acute gallstone pancreatitis.
Jian-hong HE ; Quan-bao ZHANG ; Yu-min LI ; You-quan ZHU ; Xun LI ; Bin SHI
Chinese Medical Journal 2010;123(10):1351-1352
Female
;
Gallstones
;
pathology
;
surgery
;
Humans
;
Hyperparathyroidism, Primary
;
diagnosis
;
surgery
;
Pancreatitis
;
pathology
;
surgery
;
Young Adult
8.Role of CaMK II in pancreatic injury in mice with severe acute pancreatitis.
Wen JIANG ; Jun WU ; Jia Rong ZENG ; Guang Xu JING ; Li Jun TANG ; Hong Yu SUN
Journal of Southern Medical University 2022;42(2):286-292
OBJECTIVE:
To investigate the expression of Ca2+/calmodulin-dependent protein kinase II (CaMK Ⅱ) in pancreatic tissues of mice with severe acute pancreatitis (SAP) and explore the protective effect of KN93, a CaMK Ⅱ inhibitor, against pancreatic injury in SAP and the possible mechanism.
METHODS:
Thirty-six healthy male C57 mice were randomly divided into sham operation group, SAP group, KN93 group and SAP + KN93 group (n=9). Serum and pancreatic tissue samples were collected 24 h after modeling. The pathological changes in the pancreatic tissues were observed using HE staining. Serum lipase and amylase activities and the levels of inflammatory factors were detected using ELISA. Western blotting was used to detect the expressions of CaMK Ⅱ, p-CaMK Ⅱ, p-NF-κB, MAPK and p-MAPK in mouse pancreas.
RESULTS:
Compared with those in sham operation group, the expressions of p-CaMK Ⅱ, p-NF-κB and p-MAPK were significantly increased in SAP group (P < 0.05). KN93 treatment obviously alleviated pathological injuries of the pancreas in SAP mice, and significantly lowered serum levels of lipase, amylase and inflammatory factors (TNF-α and IL-6) and phosphorylation levels of NF-κB, ERK and MAPK proteins (P < 0.05).
CONCLUSION
The activity of CaMK Ⅱ is significantly increased in the pancreatic tissue of SAP mice. KN93 can alleviate pancreatic injury and inflammation in SAP mice possibly through the ERK/MAPK signaling pathway.
Acute Disease
;
Animals
;
Inflammation/metabolism*
;
Male
;
Mice
;
NF-kappa B/metabolism*
;
Pancreas/pathology*
;
Pancreatitis/pathology*
9.Ferroptosis and its emerging roles in acute pancreatitis.
Hongyao LI ; Yujie LIN ; Ling ZHANG ; Jing ZHAO ; Peiwu LI
Chinese Medical Journal 2022;135(17):2026-2034
Acute pancreatitis (AP) is a common and potentially life-threatening pancreatic inflammatory disease. Although it is usually self-limiting, up to 20% of patients will develop into severe AP. It may lead to systemic inflammatory response syndrome and multiple organ dysfunction, affecting the lungs, kidneys, liver, heart, etc. Surviving patients usually have sequelae of varying degrees, such as chronic hyperglycemia after AP (CHAP), pancreatic exocrine insufficiency, and chronic pancreatitis. Lacking specific target treatments is the main reason for high mortality and morbidity, which means that more research on the pathogenesis of AP is needed. Ferroptosis is a newly discovered regulated cell death (RCD), originally described in cancer cells, involving the accumulation of iron and the depletion of plasma membrane polyunsaturated fatty acids, and a caspase-independent RCD. It is closely related to neurological diseases, myocardial infarction, ischemia/reperfusion injury, cancer, etc. Research in the past years has also found the effects of ferroptosis in AP, pancreatic cancer, and AP complications, such as acute lung injury and acute kidney injury. This article reviews the research progress of ferroptosis and its association with the pathophysiological mechanisms of AP, trying to provide new insight into the pathogenesis and treatment of AP, facilitating the development of better-targeted drugs.
Humans
;
Pancreatitis/pathology*
;
Acute Disease
;
Ferroptosis
;
Pancreas/pathology*
;
Acute Lung Injury/metabolism*
10.Acute necrotizing pancreatitis and postmortem autolysis of pancreas.
Guang-Hua YE ; Yi-Gu ZHANG ; Lin-Sheng YU ; Xing-Biao LI ; Jun-Ge HAN
Journal of Forensic Medicine 2008;24(2):94-101
OBJECTIVE:
To compare the pathomorphologic changes between the pancreas in acute necrotizing pancreatitis (ANP) and that in acute deaths of rats (within 48 hours) so as to find the distinctions.
METHODS:
The animal models of ANP and other acute deaths (electroshock, mechanic asphyxia/strangle, and acute poisoning with tetramine) were established according to the criteria. Half-quantitative grading and image quantitative analysis methods were employed to observe the gross and microscopic changes of the pancreases.
RESULTS:
Three features including inflammation infiltrate, fat necrosis and calcium deposit in the ANP group were considerably different from that in other acutely died rat group (P<0.05).
CONCLUSION
Inflammation infiltrate, fat necrosis and calcium deposit are the most important pathologic features found in ANP by common light microscope, distinguishing ANP from postmortem pancreatic autolysis.
Animals
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Autolysis
;
Female
;
Forensic Pathology
;
Male
;
Pancreas/pathology*
;
Pancreatitis, Acute Necrotizing/pathology*
;
Poisoning/pathology*
;
Postmortem Changes
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Rats
;
Rats, Sprague-Dawley