Chronic pancreatitis is a progressive inflammatory disease resulting from repeated episodes of acute pancreatitis that impair exocrine function and eventually produce endocrine insufficiency. Some causes of chronic pancreatitis appear to be associated with alterations in the serine-protease inhibitor, Kazal type 1 (SPINK1), cationic trypsinogen (PRSS1), and cystic fibrosis-transmembrane conductance regulator (CFTR) genes, or with structural disorders in the pancreaticobiliary ductal system, such as pancreatic divisum or anomalous pancreaticobiliary ductal union (APBDU). However, it is unusual to observe both genetic alteration and structural anomaly. Here, we report 2 cases with both APBDU and a mutation in the SPINK1 genes, and we discuss the implications of these findings in clinical practice.
Pancreatitis ; Pancreatitis, Chronic ; Trypsinogen

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Pancreatitis, Chronic*

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Pancreatitis, Chronic*

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Pancreatitis, Chronic*

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Pancreatitis, Chronic*

Chronic pancreatitis (CP) is an inflammatory disease and causes chronic pain, exocrine and endocrine function failure. Pain is major indication for surgical procedure indication in CP. Advances in noninvasive treatment now allow for better therapeutic options at an early stage of CP. However, many data show that surgical procedure may produce superior results to endoscopic treatment in CP management. Considerable controversy remains with respect to the surgical management of chronic pancreatitis. There are many surgical options to control chronic pain in CP, therefore preoperative assessment is important to choose optimal surgical management. Effective surgical procedures and timing of surgery for chronic pancreatitis remain unclear. This review comprehensively assesses the evidence for these different approaches to surgical intervention in chronic pancreatitis.
Chronic Pain ; Pancreatitis ; Pancreatitis, Chronic* ; Surgeons*

No abstract available.
Pancreatitis, Chronic* ; Pathology*

The main cause of the chronic pancreatitis were the chronic alcoholism (64%). The other etiology were hyperlipiderma (8%), malnutriation especially 16% patients had clinical biological and histogical evidences related protein malnutriation. The clinical condition were various: the abdominal pain were most common (92%). The position of pain, regardless the acute pain attack can help the diagnosis. The most comon complications were the disorder of glucose toleration (48%) and false cyst in the pancreas (32%), disorder of exocrine functions (24%) in long term studied group.
Pancreatitis, Chronic ; etiology ; diagnosis

The article presented a first 52-year woman with chronic pancreatitis and pancreatic stone who underwent Frey’s procedure at ViÖt - §øc Hospital in January 2002. This patient had admitted to hospital due to abdominal pain with vomiting. The general condition was poor; body weight was 35 kg. Skin and mucous membrane was not yellow. The patient had not edema or subcutaneous hemorrhage, blood pressure was 150/100 mmHg, and pulse was 85 rates per minute. She had history of uncontrolled hypertension. The postoperative outcome was good. The patient could eat light meal by 3 days after operation. Drain catheters were removed after 72 hours. She was free from pain. Sutures were removed after 7 days and she was released after 12 days. After 2-month follow-up, she had normal diet and activities
Pancreatitis, Chronic ; surgery ; therapeutics

Pancreatic pseudoaneurysms are possible complications of chronic pancreatitis. These may present as hemosuccus pancreaticus, a rare cause of upper gastrointestinal tract bleeding where a pseudoaneurysm erodes into an adjacent pseudocyst or pancreatic duct, manifesting as bleeding through the pancreatic duct into the duodenal papilla. We report a case of a 32-year-old male with a history of chronic pancreatitis presenting as intermittent upper gastrointestinal tract bleeding secondary to hemosuccus pancreaticus from a pancreatic pseudoaneurysm. The patient underwent multiple sessions of endovascular embolization, which successfully controlled the bleeding despite some failed attempts; thus, a potentially morbid last-resort surgery was avoided.
pseudoaneurysm ; chronic pancreatitis