1.Impact of octreotide on pancreatic fistula after pancreaticoduodenectomy: a prospective study.
Rui KONG ; Jisheng HU ; Le LI ; Gang WANG ; Hua CHEN ; Xuewei BAI ; Yongwei WANG ; Linfeng WU ; Hongchi JIANG ; Bei SUN
Chinese Journal of Surgery 2016;54(1):21-24
OBJECTIVETo investigate the effect of utilizing octreotide during perioperative period on pancreatic fistula after pancreaticoduodenectomy (PD).
METHODSThree hundreds and six patients admitted from January 2010 to October 2014, who prepared to undergo pancreaticoduodenectomy (PD) were randomly divided into octreotide group (147 cases) and control group (159 cases). In octreotide group, octreotide was used in subcutaneous injection instantly after PD, each 8 hours until postoperative 10(th) day, and patients in control group were injected with the same volume of saline. Differences of pancreatic fistula (Grade A, Grade B, Grade C), hospitalization days and treatment cost were compared. χ(2) test, t-test and Fisher exact test were used to analyzed to the data, respectively.
RESULTSNo statistical significance (P>0.05) between two groups in the incidence of pancreatic fistula after PD (Grade A: 8.8% vs. 10.2%, Grade B: 2.7% vs. 4.4%, Grade C: 0.7% vs. 1.3%; χ(2)=0.197, 0.700, 0.288; P=0.657, 0.403, 0.591), the length of hospitalization((12.1±1.2)days vs. (13.0±1.2)days)(t=1.711, P=0.104) and treatment cost (79 700±6 700 vs. 77 600±5 200)(t=1.378, P=0.185). When accompanied with high risk factors, such as soft texture of pancreas, pancreatic duct size less than 3 mm, BMI≥25 kg/m(2) and diabetes, compared with control group, octreotide group had the lower incidence rate of pancreatic fistula and clinical correlative pancreatic fistula(all P<0.05) after PD.
CONCLUSIONSGenerally, octreotide makes no contribution to reduce the incidence of pancreatic fistula after PD. However, for patients who is accompanied with high risk factors, such as soft texture of pancreas, pancreatic duct size less than 3 mm, BMI≥25 kg/m(2) and diabetes, octreotide can effectively prevent pancreatic fistula after PD.
Anastomosis, Surgical ; Humans ; Incidence ; Octreotide ; therapeutic use ; Pancreas ; pathology ; Pancreatectomy ; Pancreatic Ducts ; pathology ; Pancreatic Fistula ; drug therapy ; Pancreaticoduodenectomy ; adverse effects ; Perioperative Period ; Prospective Studies
2.Serotonin and pancreatic duct function.
Satoru NARUSE ; Atsushi SUZUKI ; Hiroshi ISHIGURO ; Motoji KITAGAWA ; Shigeru BH KO ; Toshiyuki YOSHIKAWA ; Akiko YAMAMOTO ; Hiroyuki HAMADA ; Tetsuo HAYAKAWA
Journal of Korean Medical Science 2000;15(Suppl):S27-S28
1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.
5-Methoxytryptamine/pharmacology
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Acetylcholine/pharmacology
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Animal
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Calcium/metabolism
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Guinea Pigs
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Pancreatic Ducts/metabolism*
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Pancreatic Ducts/drug effects
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Secretin/pharmacology
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Serotonin/pharmacology
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Serotonin/metabolism*
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Serotonin/analogs & derivatives*
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Vasodilator Agents/pharmacology
3.A novel Na+-dependent transporter and NHE3 mediate H+ efflux in the luminal membrane of the pancreatic duct: regulation by cAMP.
Min Goo LEE ; Wooin AHN ; Joo Young CHOI ; Shmuel MUALLEM ; Kyung Hwan KIM
Journal of Korean Medical Science 2000;15(Suppl):S29-S30
No abstract available.
1-Methyl-3-isobutylxanthine/pharmacology
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Ammonium Compounds/pharmacology
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Animal
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Biological Transport/physiology
;
Biological Transport/drug effects
;
Cell Membrane/metabolism
;
Cyclic AMP/metabolism*
;
Forskolin/pharmacology
;
Guanidines/pharmacology
;
Mice
;
Mice, Knockout
;
Pancreatic Ducts/metabolism*
;
Phosphodiesterase Inhibitors/pharmacology
;
Protons
;
Sodium-Hydrogen Antiporter/metabolism*
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Sodium-Hydrogen Antiporter/genetics
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Sulfones/pharmacology