China ; Humans ; Pancreas ; pathology

Humans ; Sarcoma, Ewing/pathology* ; Pancreas/pathology*

Carcinosarcoma is a rare neoplasm that most commonly affects the uterus. In the pancreas, fewer than thirty cases are reported worldwide. We present a 47-year-old female with epigastric pain, and jaundice. Histopathology revealed a pancreatic head mass showing a biphasic tumor composed of seventy percent Pancreatic Ductal Adenocarcinoma, and thirty percent High Grade Sarcoma with immunohistochemistry using Pancytokeratin, Vimentin, Desmin, S-100, Smooth Muscle Actin, CD34, and Ki-67.
Pancreas ; Carcinosarcoma ; Immunohistochemistry ; Pathology, Surgical ; Diagnosis

Carcinoma/pathology* ; Giant Cells/pathology* ; Humans ; Osteoclasts/pathology* ; Pancreas/pathology* ; Pancreatic Neoplasms/surgery*

Congenital duodenal obstruction is a rare cause of neonatal intestinal obstruction caused by various intrinsic and extrinsic congenital lesions. Annular pancreas is one of the causes of extrinsic duodenal obstruction and a duodenal web is one of the causes of intrinsic duodenal obstruction. The simultaneous occurrence of an extrinsic and intrinsic pathology is rare. Only four such cases have been reported in literature. We present a similar case of male neonate with partial duodenal obstruction caused by annular pancreas and an intrinsic duodenal web.
Duodenal Obstruction* ; Humans ; Infant, Newborn ; Intestinal Obstruction ; Male ; Pancreas* ; Pathology

Congenital duodenal obstruction is a rare cause of neonatal intestinal obstruction caused by various intrinsic and extrinsic congenital lesions. Annular pancreas is one of the causes of extrinsic duodenal obstruction and a duodenal web is one of the causes of intrinsic duodenal obstruction. The simultaneous occurrence of an extrinsic and intrinsic pathology is rare. Only four such cases have been reported in literature. We present a similar case of male neonate with partial duodenal obstruction caused by annular pancreas and an intrinsic duodenal web.
Duodenal Obstruction* ; Humans ; Infant, Newborn ; Intestinal Obstruction ; Male ; Pancreas* ; Pathology

Autoimmune pancreatitis(AIP)is radiologically characterized by sausage-like diffuse swelling of the pancreatic parenchyma but may also be found as a localized mass that is easily misdiagnosed as a pancreatic neoplasm.AIP presenting as multifocal masses is rare.Here we report a case of multifocal IgG4-related AIP,in which the lesions grew in size and finally fused to become radiologically typical.
Humans ; Immunoglobulin G4-Related Disease ; diagnosis ; pathology ; Pancreas ; pathology ; Pancreatic Neoplasms ; Pancreatitis ; diagnosis ; pathology

Pancreatic cancer is a malignant tumor of digestive system with poor prognosis,and surgical resection is still the only hope for a radical cure. Although the current consensus and guidelines describe in detail the standard and extended range of lymph node dissection,the selection of specific range of lymph node dissection and its impact on prognosis are still controversial. Current studies have not only proposed some improved extent of lymph node dissection, such as total mesopancreas excision and Heidelberg triangle dissection, but also suggested different extent of lymph node dissection for ventral and dorsal pancreatic head cancer. In addition, the prognosis of pancreatic head cancer in uncinate process and non-uncinate process is different after para-aortic lymph node dissection, which is worthy of further study. Neoadjuvant therapy or conversion therapy provides more surgical opportunities for patients with pancreatic cancer. For these patients, Heidelberg triangle dissection has potential value in improving prognosis. This paper summarizes the exploration and latest progress of standard and extended lymph node dissection, lymph node dissection of specific site of pancreatic head cancer and the extent of lymph node dissection after neoadjuvant/transformation therapy in recent years.
Humans ; Lymph Node Excision ; Pancreatic Neoplasms/pathology* ; Lymph Nodes/pathology* ; Pancreas/pathology* ; Prognosis

OBJECTIVETo elucidate the clinicopathological features of solid pseudopapillary tumor (SPT) of the pancreas.

METHODSEight patients with SPT of the pancreas admitted from August 1996 to March 2005 were retrospectively analyzed.

RESULTSAll the 8 patients were female with an average age of 25.3 (13-41) years. The primary clinical manifestations included abdominal mass (n = 3), vague abdominal pain (n = 3), and duodenal obstruction (n = 1). SPT was occasionally found in one patient during physical examination. Six tumors located at the head and the other two in the body and tail of the pancreas. Pancreaticoduodenectomies were performed in 4 patients, tumor enucleations in 2, distal pancreatectomies in 1, and palliative internal drainage with a cystoenterotomy in the other one with an unresectable huge cystic lesion. All patients were alive on an average follow-up of 37.8 (8-103) months.

CONCLUSIONSPT occurs mainly in adolescent and young females, and satisfactory outcome may be achieved with active and appropriate surgeries.

Adolescent ; Adult ; Carcinoma, Papillary ; diagnosis ; pathology ; Female ; Humans ; Pancreas ; pathology ; Pancreatic Neoplasms ; diagnosis ; pathology ; Prognosis

Acute pancreatitis (AP) is a common and potentially life-threatening pancreatic inflammatory disease. Although it is usually self-limiting, up to 20% of patients will develop into severe AP. It may lead to systemic inflammatory response syndrome and multiple organ dysfunction, affecting the lungs, kidneys, liver, heart, etc. Surviving patients usually have sequelae of varying degrees, such as chronic hyperglycemia after AP (CHAP), pancreatic exocrine insufficiency, and chronic pancreatitis. Lacking specific target treatments is the main reason for high mortality and morbidity, which means that more research on the pathogenesis of AP is needed. Ferroptosis is a newly discovered regulated cell death (RCD), originally described in cancer cells, involving the accumulation of iron and the depletion of plasma membrane polyunsaturated fatty acids, and a caspase-independent RCD. It is closely related to neurological diseases, myocardial infarction, ischemia/reperfusion injury, cancer, etc. Research in the past years has also found the effects of ferroptosis in AP, pancreatic cancer, and AP complications, such as acute lung injury and acute kidney injury. This article reviews the research progress of ferroptosis and its association with the pathophysiological mechanisms of AP, trying to provide new insight into the pathogenesis and treatment of AP, facilitating the development of better-targeted drugs.
Humans ; Pancreatitis/pathology* ; Acute Disease ; Ferroptosis ; Pancreas/pathology* ; Acute Lung Injury/metabolism*