New military transformation and modernization of Chinese army brings new challenges to medical equipment of PLA. This paper introduces challenges by development of science and technology, flourish of economy, medical reform and military transformation.

Objective:Examining the difference in the protein profiling of endometrium between the blastocyst-adhering side and the side without blastocyst adhering,in order to study the asynchrony of blastocysts adhesion between two uteri.Methods:The endometrium with and without blastocyst adhering from the mice pregnant for 5 days were analyzed by two-dimensional gel electrophoresis and imaging analysis.Results:The number of matched protein spots between two gels was up to 82.5%.760 and 720 protein spots with a molecular mass between 14.0～75.4 and isoelectric points (pI)from 4～7 were catalogued from silver-stained gels of the blastocyst-adhering endometrium and the endometrium without blastocyst adhering respectively.At least 60 proteins were up-regulated or down-regulated by over two folds between two groups.Conclusion:the different expression of protein profile may be a cause underlying the the asynchrony of blastocysts adhesion between two uteri.

Objective To investigate the distribution of pathogenic microbes in blood culture and analysis of drug resis-tance of common pathogens in children with acute leukemia.Methods BACTE-FX system made by BD company was applied for the blood culture of children with acute leukemia. API or VITEK-2 Compact bacterial identiifcation system was used for iden-tiifcation of bacteria. Antimicrobial susceptibility testing was performed by disk diffusion method.Results Among 6400 blood culture samples in children with acute leukemia, 713 cases were positive at the rate of 11.1%. Among 655 strains ifrst isolated from the patient, Gram-positive bacteria were 52.5% (344/655) and dominated byStaphylococcus. Strains resistant to vancomy-cin and linezolid were not found. 278 strains (42.5%) were Gram-negative bacteria , andS.marcescens andE.coli were dominat-ed. Gram-negetive bacteria showed high antibacterial activity to imipenem with the sensitive rate of 100%. 33 strains (5%) were fungi.Conclusions Staphylococcus,S.marcescens, and E.coli were the most important bacteria in blood culture of children with acute leukemia. We can offer effective help for clinical treatment with the susceptibility testing.

AIM: To investigate the effect of exercise training(EX) on the arterial baroreflex and possible mechanisms in rats with chronic heart failure(CHF).METHODS: Experiments were carried out in four groups: EX-CHF,CHF,EX-sham,and sham. CHF was induced by left coronary artery ligation,and EX consisted of 4 weeks of treadmill running. Baroreflex function,plasma angiotensin II(Ang II) and central AT1 receptor expression were determined.RESULTS: (1) The average slope and maximal gain of the baroreflex curve in CHF rats were lower than those in sham rats(P<0.01). EX significantly enhanced baroreflex parameters in CHF group but not in sham group.(2) EX decreased plasma Ang II in CHF rats ［(137±27)ng/L vs (263±55)ng/L,P<0.01］,but had no significant effect on plasma Ang II in sham rats ［(75±17)ng/L vs (92±21)ng/L］.(3) Expression of AT1R protein in the PVN of CHF rats was higher than that in sham rats(1.20±0.21 vs 0.70±0.14,P<0.01). EX reduced AT1R protein level in CHF rats(0.90±0.13),but had no impact in sham rats(0.60±0.16).CONCLUSION: EX restores the attenuated arterial baroreflex function in CHF rats,involving in decrease of plasma Ang II and downregulation of AT1R in the PVN.

OBJECTIVE:To optimize the formula of the compound ginkgo leaves tablets.METHODS:The formula(dosage of low-substituted hydroxypropyl cellulose;the ratio between crude drug and loading agent and the dosage of micro-crystalline cellulose)was optimized using orthogonal design and multi-index(tablet weight variation and disintegration de-gree)comprehensive score method.RESULTS:The optimized formula was the following:the dosage of low-substituted hy-droxypropyl cellulose was5%;the ratio between crude drug and loading agent was1∶1and the dosage of microcrystalline cellulose was10%.CONCLUSION:The tablets are reasonable in formula and the forming quality of which is also good.

To meet the requirements of military medical readiness and to win in informatized war, striding development of Chinese medical equipment has to be performed. This paper presents related guiding ideology, principle, mission, objective and countermeasures.

Objective To analyze the quantitative change of 18 elements in Culex quinquefasciatus Larvae infected by Lagenidium giganteum (Oomycetes:lagenidiales), and to explore possible mechanism of mosquito-killing by the fungus. Methods. Elements in the mosquito larvae at different developmental stages from infected and non-infected (control) groups were detected with automatic bioassay machine. Results . At the early stage of infection, content of Ca and Cu in the infected group was markedly lower while the content of Co and Cd were higher than the control. In 24 hrs after infection, the content of Ca, Mg, Na, P, Fe, Zn, Cu, Mn and Cr was significantly lower while that of K, Mo, Co, Ni, Al, Cd and Pb were higher than those in non-infected larvae. No marked difference was found for the content of Sr and B between the two groups. In 48 hrs after infection, considerable difference was found in 17 elements between infected and non-infected larvae, with only one exception of Sr. Conclusion . Many elements which play an important role in maintaining the vitality of the mosquito larvae decreased and some of the heavy metal elements accumulated after the infection of Lagenidium giganteum. This might be a part of the killing mechanism to Culex quinquefasciatus larvae.

As the people's life quality improved, more and more attention has been paid to indoor air pollution. The SBS (sick building syndrome) resulting from indoor air pollution has become an unavoidable problem in the modern life. Indoor air pollution has been listed as one of the five most dangerous environmental factors to human health. The present paper mainly analysed the prominent indoor air pollutants such as formaldehyde, radon, ammonia, nitrogen oxides and VOCs, which affect indoor air quality, and also pointed out the research direction and the high lights in this field in future.

Objective To summarize the modernization of information demand of clinical teaching and management of nursing interns, evaluate the effect of development of the nursing intern teaching management information platform in the clinical effect. Methods Through literature retrieval, inductive method, on the basis of the needs analysis of nursing interns, clinical teachers, Nursing Education Center personnel a total of 41 people were divided into 5 groups with 5-7 people each. Brainstorming method was used to build the initial module and design the questionnaire and the interview outline. The clinical teaching teacher questionnaire was investigated in 101 part and in-depth interviews. Results The recovery of 100 valid questionnaires, the effective questionnaire 99.0%(100/101) and in-depth interviews with 15 excellent clinical teachers, the final 7 first level indices and 55 two level indices; finally running test platform development and 6 months, again the clinical teacher interviews, trial platform had a satisfactory result. Conclusion The nursing intern teaching management information platform is helpful to improve the teaching quality of nursing interns and management efficiency.

Urinary albumin is a biomarker for kidney damage and is widely applied in clinical practice.With more evidence on urinary albumin, it is also recognized as a risk factor for cardiovascular disease and all-cause mortality.This paper focuses on thecurrent status of pre-analytical, mid-analytical and post-analytical process and discusses the progress in standardization of measurement for urinary albumin and the issues which call for the attention of clinical laboratorian.