1.Illegal Drug Advertisements: Causes and Countermeasures
China Pharmacy 2007;0(31):-
OBJECTIVE: To provide references for the control of drug advertisements in China. METHODS: The reasons accountable for the illegal drug advertisements that failed to be eliminated were investigated thoroughly by summarizing their manifestation patterns, meanwhile some corresponding countermeasures were brought forward. RESULT & CONCLUSION: The department concerned should strengthen the control of drug advertisements, purify drug advertisement market, and prevent the hidden danger of drug safety from happening.
2.Diabetes and osteoporosis
Chinese Journal of Practical Internal Medicine 2001;0(10):-
Diabetic Osteoporosis is a general metabolic bone disease having fracture tendency because of osteopenia in unit volume,microstructural changes of bone tissue,decreased bone strength and increased friability,which is one of important complications of diabetes mellitus in skeletal system.Studies on bone involvement in patients with diabetes mellitus have generated conflicting results,largely because of the pathogenetic complexity of the condition.There are many factors,including advantageous and disadvantageous factors,influence the probability of osteoporotic fractures in diabetics.Adequate glycemic control,and calcium and vitamin D intakes,and the prevention and treatment of diabetic complications are key elements in the elimination of osteoporosis in diabetes mellitus.Patients with osteoporosis and diabetes should be offered the same pharmacological treatments as non-diabetics.
3.Comments of spleen-yin theory of doctors of Ming Dynasty
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(04):-
Spleen-yin theory was the innovation of doctors in Ming Dynasty for Piwei theory of Dongyuan based on the inheritance of nourishing yin theory of Danxi. But because of rise of stomach yin theory, spleen yin theory was ignored gradually. This article revealed the neutralizing therapeutic conception contained in this theory, which was hoped to be applyed into medical practice and to be deepened furtherly.
4.The Application of Customer Relationship Management in Retail Drugstores
China Pharmacy 1991;0(04):-
OBJECTIVE:To provide advices on how to apply to the theory of customer relationship management in retail drugstores.METHODS:The theory of customer relationship management was briefly expounded and its application in the real management of drugstores was analyzed.RESULTS&CONCLUSION:Only after the retail drugstore putting the ideas of customer relationship management into their everyday work according to their own features can their function brought into full play.
5.The structure-function relationship analysis of VEGI: Y111 is an important residue in biological activity
Min ZHANG ; Jingjuan YAO ; Xin PAN ; Wei PAN ; Zhongtian QI
Chinese Pharmacological Bulletin 1987;0(03):-
Aim Vascular endothelial cell growth inhibitor(VEGI) is a recently discovered novel member of the TNF superfamily,which is expressed predominantly in endothelial cells.As an endothelial cell-specific negative regulator of angiogenesis,the relationship between structure and function of VEGI is not understood at present.Methods In order to explore the functional key amino acids of VEGI,four mutants of VEGI(E45→R,G47→A,Y111→F,Y111→T) were construced by site-directed mutagenesis,and recombinant proteins were generated from E.coli.Four mutant proteins behaved similar to the wild type VEGI in various physico-chemical assays.The proliferation of HUVEC and chick choriallantic membrane assay were performed to study the activity of four mutants.Results The mutant E45→R significantly decreased the biological activity,and the mutant G47→A caused a slight drop on activity,but the mutants Y111→F,Y111→T almost completely abolished biological activity.Conclusion It suggests that Y111 is an important residue in biological activity,which may play a direct role in receptor recognition.Moreover,the tyrosine ring and hydroxy group of the amino acid are important determinant of biological activity.Additionally,E45 also plays an important role in biological activity of VEGI.
6.Clinical comparison of intraosseous versus traditional infusion in critical pediatric patients under resuscitation
Yingrong LIN ; Qi PAN ; Lingling LUO ; Danfeng PAN
Chinese Journal of Primary Medicine and Pharmacy 2016;23(21):3240-3243
Objective To compare the clinical effect of intraosseous versus traditional infusion in critical pediatric patients under resuscitation.Methods 56 critical pediatric patients under resuscitation,who were difficult to establish a venous access,were divided into two groups:intraosseous infusion group (IOI group)and traditional group.The clinical characteristics,lab tests,clinical efficacy and complications of all patients were recorded in detail. Results The general characteristics of two groups were comparable.The mean operation time to establish an emergency infusion access in the IOI group was (1.01 ±0.53)min,which was significantly shorter than (8.97 ±2.36)min of the traditional group(t =4.856,P <0.01).The IOI group had a greater efficacy over the traditional group (50.0% vs 36.7%),in the IOI group,the patients showed obvious positive effect and less patients had no efficacy(χ2 =18.476, P <0.05 ).In addition,lower complication rate and mortality were observed in the IOI group.Conclusion For critical pediatric patients under resuscitation whose intravascular access cannot be achieved through peripheral venous,intraosseous infusion is prior to traditional infusion.
7.Studies on the clinical characteristics of intestinal infection caused by Aeromonas and drug susceptibility of the strains
Jian PAN ; Tingju ZHANG ; Jie QI
International Journal of Laboratory Medicine 2014;(8):971-972
Objective To analyze the clinical characteristics of intestinal infection caused by Aeromonas and their drug suscepti-bility .Methods The data of 52 patients infected with Aeromonas were analyzed retrospectively .Aeromonas strains were identified with Vitek Ⅱ Compact .Drug susceptibility was determined by disk diffusion methods .Cefoxitin combined with ceftazidime ,aztreo-nam ,cefotaxime and ceftriaxone were used to detect inducible expression of AmpC β-lactamase .Results Abdominal pain ,watery di-arrhea ,tenesmus occurred in 75 .0% ,48 .1% ,and 38 .0% of the patients ,respectively .White blood cell tests were positive in 50 .0%patients′stools .52 strains of Aeromonas were isolated ,including 38 strains of Aeromonas hydrophila ,13 strains of Aeromonas so-bria ,and 1 strain of Aeromonas veronii .All strains were sensitive to carbapenems ,the second ,third generation of cephalosporins , monobactam ,fluoroquinolone ,aminoglycosides .The susceptibility rates to chloramphenicol ,trimethoprim-sulfamethoxazole ,cefox-itin ,cefazolin ,and amoxicillin/clavulanic acid were 94 .2% ,92 .3% ,76 .9% ,51 .9% and 23 .1% ,respectively .75 .0% isolates exhibi-ted inducible expression of AmpC β-lactamas .Conclusion Diarrhea caused by A eromonas has different clinical manifestations .Ceph-alosporins ,monobactam ,fluoroquinolone ,aminoglycosides are available for empirical therapy of diarrhea caused by A eromonas .But the third generation of cephalosporins should be cautiously used because of high prevalence of inducible AmpC β-lactamase in A ero-monas .
8.Real-time quantification of microRNAs by RNA-tailing and primer-extension RT-PCR
Qi ZHANG ; Xiangjun HE ; Xiuying PAN
Journal of Peking University(Health Sciences) 2004;0(01):-
Objective: To optimize and evaluate the modified RNA-tailing and primer-extension RT-PCR method in relative quantification of microRNAs (miRNAs) in several kinds of tissues. Methods: Small-sized RNAs (
9.Comparative Analysis of Computed Tomography and Conventional Radiography in Diagnosis of Hip Joint Trauma
Qi KE ; Zhouxin XU ; Xianwei PAN
Journal of Practical Radiology 2000;0(02):-
Objective:To compare the efficacy of computed tomography(CT)and comventional X-ray plain film in assessing hip joint trauma.Methods:76 patients with hip joint trauma were studied by CT and X-ray plain film.The efficacy of CT and X-ray plain film in assessing the acetabular fracture,femoral head and neck fracture,intra-articular loose bone fragment,dislocation of hip joint,and para-articular soft tissue injuries was evaluated and compared.Results:CT was superior to X-ray plain film in demonstrating acetabular fracture,femoral head fracture and intraarticular loose bone fragment.CT was also effectively in revealing of intra-articular effusion and hemorrhage,paraarticular soft swelling.Conclusion:CT was a necessary way to evaluated hip joint trauma,and was more effective than X-ray plain film in diagnosis of hip joint trauma.
10.The Waters classification of glenohumeral joint deformity secondary to shoulder internal rotational contracture of brachial plexux birth palsy
Shufeng WANG ; Yongwen PAN ; Qi HU
Chinese Journal of Orthopaedics 1996;0(09):-
Objective To evaluate the correlation between the Waters classification based on shoulder CT or MRI scan and passive shoulder external rotational angle before operation in the glenohumeral joint deformity caused by shoulder internal rotational contracture secondary brachial plexus birth palsy.Methods 33 patients suffered the shoulder internal rotational contracture secondary brachial plexus birth palsy (Tassin classification Ⅱ 19, Ⅲ 13, Ⅳ 1) including 12 girls and 21 boys, ranging from 10 months to 16 years old with an average of 4.5 years old, underwent either CT or MR examination in shoulder joint. The retroversion of the glenoid (glenoscapular angle) and the ratio of humeral head posterior subluxation were measured on the CT or MRI images according to the method described by Friedman. The deformity of glenohumeral joint was classificated according to the Waters criteria, while the passive shoulder external rotational angle was measured at neutral position in involved shoulder joint. The correlation between the external rotation and the deformity was analysed. Results 33 cases with shoulder internal rotational contracture secondary brachial plexus birth palsy were evaluated according to the Waters criteria. 4 cases were classified as typeⅠdeformity, 4 cases as typeⅡ, 7 cases as type Ⅲ, 6 cases as type Ⅳ; 5 cases as typeⅤ; 7 case as type Ⅵ. The type of glenohumeral deformity was significantly associated with the limited range of passive external rotation of the shoulder joint. Conclusion The Waters classification of the glenohumeral deformity according to the Waters criteria can accurately demonstrated the deformity of the glenohumeral joint caused by shoulder internal rotational contracture secondary to brachial plexus birth palsy.