Ischemic stroke is one of the major diseases of causing adult disability and death.Age,sex,smoking,hypertension,and diabetes,etc.are the risk factors for ischemic stroke,but they can only partially explain the reasons of stroke onset.Twins,families,and single-gene genetic stroke studies have shown that ischemic stroke has obvious genetic predisposition.In recent years,genomics has made remarkable progress in ischemic stroke study and has shown that many new single nucleotide polymorphisms or genes are associated with ischemic stroke and its risk factors.However,the contribution of these genetic genes for ischemic stroke is still too small and the repetitive studies are needed for further confirmation.

Objective To establish the quality standard for Kangyuan Granula. Methods Radix Astragali, Radix Paeoniae Alba, Fructus Lycii and Radix et Rhizoma Glycyrrhizae in this prescription were identified by TLC. The content of the Paeoniflorin was determined by HPLC. The column of AichromBond-AQ-C18 (4.6 mm?150 mm, 5 ?m) was used, the mobile phase was Water-Acetonitrile (85∶15), at the flow of 1.0 mL/min, the column temperature of 30 ℃, and peaks were detected at 230 nm. Results The characteristic of identification by TLC was distinct and highly specific. The linear range of Paeoniflorin was 0.0545～0.545 ?g, r =0.999 5, the average recovery was 97.90%, RSD=1.06% (n =6). Conclusion The method was easy to operate with accurate result and good reproducibility. It can be used effectively for the quality control of this preparation.

Currently targeted therapy of breast cancer therapy has become the hot research field and a kind of brand-new biological treatment mode after three traditional pattern of the surgery, radiotherapy and chemotherapy for breast cancer. Molecular targeted therapy is aimed at the target that may cause cancer cells, such as protocarcinogenic genes and tumor-suppressor genes, cell signaling pathways, cytokines and receptors, antiangiogenesis etc. It can reverse malignant biology behavior to inhibit tumor cell growth from the molecular level and has the advantages of high specific effects and low side effects. This paper focuses on the drug of the molecular targeted therapy for breast cancer and the latest progress of targeted therapy.

OBJECTIVE: To establish a bacterial endotoxin test method for fluorescein sodium injection.METHODS: Based on the bacterial endotoxin test method stated in Chinese Pharmacopoeia 2005 edition(second part),an interference test was conduced on different batches of fluorescein sodium samples using tachypleus amebocyte lysate from different companies.RESULTS: At a concentration of no more than 0.75 mg?mL-1,fluorescein sodium showed no interfere with the bacterial endotoxin test.CONCLUSION: It is feasible for bacterial endotoxin test of fluorescein sodium injection be conducted in a limit value of 0.15 EU?mL-1.

Objective To explore the clinical value of early arterial phase (EAP) enhanced imaging with MSCT in detecting liver focal lesions.Methods 100 patients with liver focal lesions were examined with MSCT scan.The images were analyzed.Results There were 85.0％ of the 100 cases that demonstrated EAP enhancement,which was hemangioma of liver(100.0％),hepatapostema (100.0％),hepatocellular carcinoma (95.0％),liver metastasis (84.0％),and cholangiocellular carcinoma(25.0％) in descending order.The abnormal vascular lesions and heterogeneous enhancement had high sensitivity and specificity for hepatocellular carcinoma,and the edge nodular enhancement for hemangioma,and the ring enhancement for metastases.Conclusion The EAP enhanced imaging with MSCT in detecting liver focal lesions has great applicative value.

Medical institutes in the United States,the United Kingdom and Canada have systematically explored and published standard of physician competence,such as ACGME six-critical-components,GMC good medical practice and CanMEDS,which has led to changes in the content,item format and clinical skill test of foreign medical incensing exam.Foreign research inspires Chinese counterparts to study and develop the Chinese standard of physician competence so as to continuously enhance the medical licensing exam.

Putting emphasis on medical science education and looking down on medical humanistic education is the situation in medical colleges.Reasons of absence of medical humanistic education are as follows,one is the insufficient understanding of medical humanism and the other is the lack of practice.Learning traditional culture can make up for the deficiency of medical humanities education.Caring life and humanitarian spirit is the main value of traditional culture and expounding medical humanitarian spirit plays an important part in medical humanities education.Traditional culture education will cultivate student's virtue,open up the wisdom and construct the harmonious spiritual home.

Objective To investigate the clinical efficacy and safety of phaocemulsification and intraocular lens combined with goniosynechialysis(Phaco + IOL + GSL) for treating the patients with primary angle closure glaucoma(PACG) with cataract.Methods 136 cases (141 eyes) PACG and cataract patients underwent the surgical treatment,their clinical data were retrospectively analyzed.67 cases(69 eyes) underwent Phaco + IOL + GSL surgical treatment(treatment group) and 69 cases (72 eyes) underwent Phaco + IOL + TBL surgical treatment (control group).The surgical treatment effects were compared and analyzed between two groups.Results At postoperative 1-month,3-months,6-months and 12-months,the intraocular pressure of treatment group was (13.32 ± 1.63) mm Hg,(14.43 ± 1.84)nn Hg,(14.65 ± 1.80) mm Hg and (14.73 ± 1.88)mm Hg respectively,the visual acuity was (0.423 ± 0.091),(0.472 ± 0.088),(0.615 ± 0.109) and (0.682 ± 0.127) respectively,the anterior chamber depth was (2.75 ± 0.59) mm,(2.97 ± 0.56) mm,(3.25 ± 0.58) mm and (3.41 ± 0.64) mm respectively.The intraocular pressure of control group was (17.35 ± 2.13)mm Hg,(16.87 ± 2.15) mm Hg,(16.31 ± 2.00) mm Hg and (15.68 ±2.02)ram Hg respectively,the visual acuity was (0.321 ±0.069),(0.362 ±0.062),(0.354 ±0.069)and (0.381 ±0.088) respectively,the anterior chamber depth was (2.21 ±0.48)mm,(2.35 ±0.40)mm,(2.41 ±0.47)mm and (2.43 ± 0.56)mm respectively.Compared with the control group,the intraocular pressure significantly reduced,visual acuity significantly increased and anterior chamber depth significantly increased of treatment group in posto perative 1-month,3-months,6-months and 12-months(all P ＜0.05).There were no serious complications in the two groups.Concluslon The triple therapy of Phaco + IOL + GSL has better clinical efficacy and security,and the therapy is worthy of clinical application.

Locally advanced non-small cell lung cancer (LA-NSCLC) usually is inoperable because of tumor progress.At present,concurrent chemoradiotherapy has become standard regimen of these patients,which has gotten remarkable effectiveness.This article is a summarization on concurrent chemoradiotherapy for LA-NSCLC.

ObjectiveTo explore the influence of different hemostatic measures of laparoscopic ovarian cyst removed on ovarian function.MethodsSeventy patients with ovarian cyst who performed laparoscopic ovarian cysts removed between January 2009 and December 2010 were randomly divided into group Ⅰ (23 cases) and group Ⅱ (47 cases) by mechanical sampling.Group Ⅰ with bleeding electrocautery,group Ⅱ with suture.Estradiol,follicle puncture hormone (FSH),luteinizing hormone (LH),number of sinusoidal follicles,normal ovarian function and the number of declining ovarian reserve were compared in two groups before operation and after 6 months operation.ResultsAfter operation,the proportion of group Ⅱ with normal ovarian function was significantly higher than that of group Ⅰ[80.9％(38/47) vs.39.1％(9/23),P ＜ 0.05 ],estradiol and number of sinusoidal follicles were significantly higher than those of group Ⅰ [( 198.4 ± 24.4) pmol/L vs.( 153.4 ± 16.8) pmol/L,7.1 ± 2.4 vs.5.8 ± 0.9](P＜ 0.05),FSH and FSH/LH were significantly lower than those of group Ⅰ[ ( 10.58 ± 4.57) U/L vs. ( 13.72 ± 2.58) U/L,2.34 ± 1.32 vs.2.82 ± 0.88 ] (P ＜ 0.05).ConclusionDuring laparoscopic ovarian cyst removed,using electrocautery can significantly reduce residual ovarian function,but using suture hemostasis can effectively protect residualovarian function.