1.New progress of molecular targeted therapy for breast cancer
Chinese Journal of Disease Control & Prevention 2008;0(06):-
Currently targeted therapy of breast cancer therapy has become the hot research field and a kind of brand-new biological treatment mode after three traditional pattern of the surgery, radiotherapy and chemotherapy for breast cancer. Molecular targeted therapy is aimed at the target that may cause cancer cells, such as protocarcinogenic genes and tumor-suppressor genes, cell signaling pathways, cytokines and receptors, antiangiogenesis etc. It can reverse malignant biology behavior to inhibit tumor cell growth from the molecular level and has the advantages of high specific effects and low side effects. This paper focuses on the drug of the molecular targeted therapy for breast cancer and the latest progress of targeted therapy.
2.Method of Bacterial Endotoxin Test of Fluorescein Sodium Injection
China Pharmacy 2005;0(13):-
OBJECTIVE: To establish a bacterial endotoxin test method for fluorescein sodium injection.METHODS: Based on the bacterial endotoxin test method stated in Chinese Pharmacopoeia 2005 edition(second part),an interference test was conduced on different batches of fluorescein sodium samples using tachypleus amebocyte lysate from different companies.RESULTS: At a concentration of no more than 0.75 mg?mL-1,fluorescein sodium showed no interfere with the bacterial endotoxin test.CONCLUSION: It is feasible for bacterial endotoxin test of fluorescein sodium injection be conducted in a limit value of 0.15 EU?mL-1.
3.Advances in genomics for ischaemic stroke
International Journal of Cerebrovascular Diseases 2012;(10):751-756
Ischemic stroke is one of the major diseases of causing adult disability and death.Age,sex,smoking,hypertension,and diabetes,etc.are the risk factors for ischemic stroke,but they can only partially explain the reasons of stroke onset.Twins,families,and single-gene genetic stroke studies have shown that ischemic stroke has obvious genetic predisposition.In recent years,genomics has made remarkable progress in ischemic stroke study and has shown that many new single nucleotide polymorphisms or genes are associated with ischemic stroke and its risk factors.However,the contribution of these genetic genes for ischemic stroke is still too small and the repetitive studies are needed for further confirmation.
4.Study on Quality Standard for Kangyuan Granula
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(10):-
Objective To establish the quality standard for Kangyuan Granula. Methods Radix Astragali, Radix Paeoniae Alba, Fructus Lycii and Radix et Rhizoma Glycyrrhizae in this prescription were identified by TLC. The content of the Paeoniflorin was determined by HPLC. The column of AichromBond-AQ-C18 (4.6 mm?150 mm, 5 ?m) was used, the mobile phase was Water-Acetonitrile (85∶15), at the flow of 1.0 mL/min, the column temperature of 30 ℃, and peaks were detected at 230 nm. Results The characteristic of identification by TLC was distinct and highly specific. The linear range of Paeoniflorin was 0.0545~0.545 ?g, r =0.999 5, the average recovery was 97.90%, RSD=1.06% (n =6). Conclusion The method was easy to operate with accurate result and good reproducibility. It can be used effectively for the quality control of this preparation.
5.Attention should be paid to the measurement of cardiac troponin in emergency room
Chinese Journal of Laboratory Medicine 2017;40(6):411-413
Cardiac troponin (cTn) is currently the most sensitive and specific marker of myocardial injuryandhas been widely used in clinical practice.Measurement of cardiac troponin in emergency room is every important in the diagnosis of acute heart disease, attention should be paid to cTn specimen type, turnaroud time and rapid detection methods and other issues when use cTn in emergency settings, in order to provide rapid and accurate results.
6.CHEN Ying-yi's experience in treating chronic diarrhea
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(07):-
The article summed up the experience of CHEN Ying-yi in treating chronic diarrhea.Chen held that the main pathogenesis of chronic diarrhea were the disharmony between the liver and the spleen,commonly impairing the function of kidney,therefore the treatment principle should focus on regulating the liver and invigorating the spleen. Invigorating the spleen should distinguish replenishing qi,tonigying yin and warming yang.Regulating the liver had to discriminate the excess and defi ciency of liver's conveyance and dispersion.Long-time diarrhea will impair the function of kidney.If it damaged the kidney-yang,we should warm up Governor Vessel to lift the kidney-yang.If it damaged the kidney-yin,we should nourish kidney-yin by replenishing kidney-yang.In this article,the author listed the basic prescription of CHEN Ying-yi in treating chronic diarrhea and his clinical experience,which can be used as references in clinic practice.
7.TRANILAST ADMINISTRATION TIME FOR SUPPRESSION OF BURN SCAR HYPERPLASY
Modern Hospital 2015;15(5):96-97,100
Objective To study the clinical effects of oral administration of tranilast to suppress burn scar hyperplasy when the burn wounds began repairing or were completely healed.Methods Sixty burn patients from July 2011 to December 2013 were randomly divided into groups A and B, 30 patients in each group.Thirty patients were treated with orally-administered tranilast at the beginning of wound repair, while the other patients were treated with orally administered tranilast when the burn wounds were completely healed.The therapeutic effect of these two groups was compared.Results Six months after burn wound healing, Vancouver scar scale was applied to evaluate the ther-apeutic effect.No significant differences were found between these two groups ( p>0.05) , and no adverse reactions were observed.Conclusion No significant differences in clinical effects of oral tranilast administered at the begin-ning of burn wound repair and at the time point of complete healing.
8.Cultivating graduate students’communication and mentoring ability
Chinese Journal of Medical Education Research 2003;0(04):-
This paper discusses practice of training graduate students’communication and mentoring ability.The mentors help the graduate students communicate with the undergraduates to grasp the experiment skills through evaluation on the spot. Communication and discussion skills are used to transmit the graduate students’ standards and expectation to help them get the correct contents.The strategies help undergraduates become outstanding experimentalists and improve quality of graduate training.
9.Our thoughts for Traditional Chinese Medicine talented persons
Chinese Journal of Medical Education Research 2003;0(04):-
On the base of the character of TCM itself,both the independent founded col-leges of TCM,or a TCM specialty in western medical college should follow the objective rules of the TCM education to exerst most of the advantages,and the outstanding features and to train the qualified TCM talented persons,in order to develop the TCM education healthily.
10.The surgical treatment of pectus excavatum in infants
Journal of Chongqing Medical University 1987;0(01):-
Objective:To review the surgical experience with pectus excavatum deformities in infants.Methods:Retrospective study was carried out on 43 infants with pectus excavatum deformities from January 1994 to October 2001.There were 31 male patients and 12 female patients.40 patients with PE underwent modified sternal elevation and 3 sternal turn-over operation.Results:Except one case of associated pneumonia and another of wound infection,the other cases had normal contours.The follow-up period was 6 months~7 years postoperatively.Except that two had logical notch and one had a flat contour in thorax,all patients had satisfactory results.Conclusion:Pectus excavatum deformities can be early operated.Correction of pectus excavatum by using sternal elevation procedure and fixation with Lucite results in an excellent cosmetic outcome.