Psoriasis is a chronic recurrent inflammatory skin disease,and its pathogenesis is still unclear.At present,it is believed that immune,genetic and environmental factors play important roles in the occurrence of psoriasis.More and more studies have indicated that the imbalance of intestinal flora is associated with immune diseases,especially inflammatory bowel disease.The pathogenesis and clinical manifestations of psoriasis are similar to those of inflammatory bowel disease,and psoriasis is proved to be associated with changes in intestinal microbial flora.This review discusses the association between the imbalance of intestinal flora and psoriasis.

Three cases of dermatomyositis presenting with inverse Gottron's papules were reported.Of the 3 patients,there were 2 males and 1 female aged 43,41 and 46 years respectively,whose disease durations were 1,6,7 months respectively.Inverse Gottron's papules manifested as papules overlying the palmar aspect of the metacarpal and interphalangeal joints,which were arranged in a linear pattern in 2 cases.Of the 3 cases,1 presented with interstitial pneumonia,3 with myositis,and 2 showed negative anti-nuclear antibody test.Histopathological examination of inverse Gottron's papules in 1 case revealed focal liquefaction degeneration of basal cells and perivascular infiltration with inflammatory cells,especially lymphocytes,in the superficial dermis.The 3 patients received oral glucocorticoids and immunosuppressive agents in the early period of treatment.After 3-month treatment,clinical symptoms including muscle weakness and muscle pain were improved evidently,but no obvious improvement in inverse Gottron's papules was observed.After 1-year treatment,these papules on the palmar aspect were markedly relieved in 1 case.