1.Preparation of 125I-Iodotyraminehemisuccinyltaxol ( 125ITHT ) for Competitive Taxol Radioimmunoassay.
Chang Woon CHOI ; Sang Moo LIM ; Ok Doo AWH ; Tae Sup LEE ; Tae Hyun CHOI ; Hyun Suk KIM ; Jun Pyo HONG ; Eun Sook LEE
Korean Journal of Nuclear Medicine 2002;36(2):121-132
No abstract available.
Paclitaxel*
;
Radioimmunoassay*
2.Radiation Recall Dermatitis after Treatment with Paclitaxel and Cisplatin.
Seung Woo BAEK ; Young Joon SEO ; Jun Sang KIM ; Hyo Jin LEE
Annals of Dermatology 2012;24(2):223-224
No abstract available.
Cisplatin
;
Paclitaxel
;
Radiodermatitis
3.Characterization of purified coconut oil bodies as an encapsulating agent for Doxorubicin and Paclitaxel
Pamela T. Aliman ; Ronina Franne N. Cada ; Mark Kevin P. Devanadera ; Alexis M. Labrador ; Myla R. Santiago-Bautista
Acta Medica Philippina 2021;55(4):442-450
Introduction:
Doxorubicin (DOX) and paclitaxel (PTX) are both widely used anticancer drugs with a broad spectrum of antitumor activity, commonly against breast, ovarian, and lung cancers. Currently, these drugs are commercially available in liposomal formulations for their use in chemotherapy. This study generally proposed coconut oil bodies (COB) obtained from Cocos nucifera L. as an alternative carrier for DOX and PTX rather than the currently used liposome.
Objectives:
This study aimed to compare standard liposome and coconut oil bodies as drug carriers in terms of their microencapsulation efficiencies, lipid profiles, in vitro drug release and stability, as well as their cholesterol levels.
Methods:
Coconut oil bodies (COB) were isolated and purified from Cocos nucifera L. by modified sucrose
gradient method followed by microencapsulation of standard drugs (doxorubicin and paclitaxel) through selfassembly and freeze-thaw method. The two standard drugs were encapsulated using COB and standard liposome. Encapsulation efficiency of both materials were determined. Lipid profiles of both encapsulating materials were analyzed by Fourier-transform infrared spectroscopy, gas chromatography-flame ionization detector, and cholesterol level determination. In vitro drug release and pH stability of both encapsulated drugs were analyzed.
Results:
Doxorubicin (DOX) and paclitaxel (PTX) were successfully incorporated in COB. Lauric acid was mainly
abundant in COB and was able to lower cholesterol levels (5 mg/dL). COB incorporated with DOX and PTX
showed stability at acidic and neutral pH. Drug release profile showed a rapid outburst within 3 hours compared to liposome encapsulated DOX and PTX.
Conclusion
Our study showed the encouraging potentials of using COB as wall materials that will make them
attractive candidates for the formulation of pharmaceuticals for optimized drug delivery of cancer chemotherapeutics DOX and PTX
Liposomes
;
Doxorubicin
;
Paclitaxel
4.A case of neoadjuvant chemotherapy with taxol / carboplatin in advanced epithelial ovarian cancer.
Korean Journal of Obstetrics and Gynecology 2000;43(10):1874-1878
No abstract available.
Carboplatin*
;
Drug Therapy*
;
Ovarian Neoplasms*
;
Paclitaxel*
5.Treatment of Disseminated Classic Type of Kaposi's Sarcoma with Paclitaxel.
Soo Yeon KIM ; Dae Hoon KIM ; Hyo Jin LEE ; Young Joon SEO ; Jeung Hoon LEE ; Young LEE
Annals of Dermatology 2011;23(4):504-507
Classic Kaposi sarcoma (KS) is a rare human herpes virus 8-associated angioproliferative disease, and the disseminated classic type of KS in Korea is even rarer. The treatment options for classic KS vary and range from surgical excision to ionizing irradiation or chemotherapy. Recently, there have been a few reports of treating classic KS with paclitaxel, which has been used to treat AIDS-associated KS and post-transplant KS. We herein report a case of disseminated classic type KS in a 78-year-old Korean male patient who showed dramatic response after only two cycles of paclitaxel treatment.
Humans
;
Korea
;
Male
;
Paclitaxel
;
Sarcoma, Kaposi
;
Viruses
6.Phase II Study of Cisplatin, Ifosfamide . Paclitaxel (CIP) as Neoadjuvant Chemotherapy in Patients with Locally Advanced Cervical Carcinoma.
Seog Beom YOON ; Jong Kug LEE ; Seob JEON ; Ji Yeon LEE ; Seung Do CHOI ; Dong Han BAE
Korean Journal of Obstetrics and Gynecology 2000;43(10):1763-1768
No abstract available.
Cisplatin*
;
Drug Therapy*
;
Humans
;
Ifosfamide*
;
Paclitaxel*
7.A Case of Squamous Cell Carcinoma of The Ovary Showing Complete Remission to Combination Chemotherapy Composed of Paclitaxel and Cisplatin.
Jin Dong JEON ; Eun Gyung CHOI ; Eun Mi JO ; Young Tae KIM ; Jae Wook KIM
Korean Journal of Obstetrics and Gynecology 2000;43(8):1492-1496
No abstract available.
Carcinoma, Squamous Cell*
;
Cisplatin*
;
Drug Therapy, Combination*
;
Female
;
Ovary*
;
Paclitaxel*
8.The Hidden Culprit: A Case of Repeated Anaphylaxis to Cremophor.
Young Nam KIM ; Jun Young KIM ; Ji Won KIM ; Jin Hae KIM ; Hye In KIM ; Sehyo YUNE ; Dong Chull CHOI ; Byung Jae LEE
Allergy, Asthma & Immunology Research 2016;8(2):174-177
Drug-induced anaphylaxis is a big pitfall in patients receiving antineoplastic chemotherapy. We report a case of lung cancer patient who experienced two near-fatal anaphylactic reactions that resulted from paclitaxel and multivitamin, seperately. Recurrent severe reactions to different agents led to further investigation to which material the patient was hypersensitive. The skin prick test revealed sensitization to cremophor, which is a commonly used emulsifying agent. This case emphasizes the importance of correctly identifying the culprit drug of anaphylaxis to avoid potentially fatal reaction.
Anaphylaxis*
;
Drug Therapy
;
Humans
;
Hypersensitivity
;
Lung Neoplasms
;
Paclitaxel
;
Skin
9.Effect of Music Therapy as Intervention on Peripheral Neuropathic Pain and Anxiety of Gynecologic Cancer Patients Undergoing Paclitaxel Chemotherapy.
Gie Ok NOH ; Moon Sook HWANG ; Keum Sook CHO ; Joung Ah LIM ; Mi Kyung KANG ; Hyo Jin KIM ; Ji Youn KIM
Korean Journal of Women Health Nursing 2011;17(3):215-224
PURPOSE: This study was to investigate the effect of music therapy as intervention on peripheral neuropathic pain and anxiety of gynecologic cancer patients who were undergoing paclitaxel chemotherapy. METHODS: Hospitalized 62 patients were assigned to an experimental group (n=30) and a control group (n=33) in this quasi-experimental study. The experimental group participated in music therapy that includes listening, singing and song writing during 1 hour. The peripheral neuropathic pain, anxiety and depression were examined as pre-intervention evaluation by using pain scale, anxiety scale (20 questions) and depression scale (20 questions) in both groups. There were no further treatments for the control group while the experimental group involved in music therapy. The peripheral neuropathic pain and anxiety were evaluated in both groups as post-intervention evaluation. RESULTS: Outcomes were verified through hypothesis testing. The level of peripheral neuropathic pain and anxiety in the experimental group was decreased, compared to the control group. CONCLUSION: According to the study, music therapy is a beneficial intervention that reduces peripheral neuropathic pain and anxiety in gynecologic cancer patients. These findings are encouraging and suggest that music therapy can be applied as an effective intervention for minimizing chemotherapy related symptoms.
Anxiety
;
Depression
;
Humans
;
Music
;
Music Therapy
;
Neuralgia
;
Paclitaxel
;
Singing
;
Writing
10.Comparative Effects of Paclitaxel and Nitric Oxide on Superficial Murine Bladder Tumor Cells.
Byoung Sun AHN ; Hyun Jeong KWAK ; Hyun Ock BAE ; Ji Chang YOO ; Chang Duk JUN ; Jeong Sik RIM ; Hun Taeg CHUNG
Korean Journal of Immunology 2000;22(4):235-245
No abstract available.
Nitric Oxide*
;
Paclitaxel*
;
Urinary Bladder Neoplasms*
;
Urinary Bladder*