Rapid technological developments in medicine have taken place in the Asia-Pacific region over the last decades. Radiology, in particular, has seen enormous growth with the latest medical equipment and practices being commonplace in this region. The use of radiation in medicine must be carefully considered with regard to the potential side effects, such as radiation-induced cancer. There are very limited published papers on the use of radiation in medicine in this region. Hence, in this paper, we present an overview of the use of radiation in medicine in the Asia-Pacific region.
Asia ; Developing Countries ; Humans ; Pacific Islands ; Radiation Oncology ; statistics & numerical data ; Radiotherapy ; utilization

Influenza A and B viruses cause significant human disease worldwide through regular outbreaks and epidemics of seasonal influenza, and occasional pandemics when a novel influenza A virus emerges. Whereas Australia and New Zealand have well-established systems for community and laboratory-based surveillance of influenza, most other countries of the Pacific are only beginning to develop such systems with the support of various global and regional agencies and networks. Here we describe the role of the World Health Organization Global Influenza Surveillance Network and other organizations in laboratory-based influenza surveillance in the region and review some of the available data on seasonal and pandemic influenza in the developed and developing countries of the Pacific. The particular features of the Pacific Island countries and territories as small dispersed island communities, together with the greater susceptibility of indigenous people to the severe effects of influenza, highlight the importance of developing local laboratory-based surveillance systems. Such systems will improve the understanding, detection and control of seasonal influenza while also providing early warning of the emergence of potential pandemic viruses.
Disease Outbreaks ; Humans ; Influenza, Human/epidemiology ; Influenza, Human/virology ; Pacific Islands/epidemiology ; Population Surveillance ; Seasons ; World Health Organization.

OBJECTIVES: Gentamicin (GM) is a commonly used aminoglycoside antibiotic that generates free oxygen radicals within the inner ear, which can cause vestibulo-cochlear toxicity and permanent damage to the sensory hair cells and neurons. Piper longum L. (PL) is a well-known spice and traditional medicine in Asia and Pacific islands, which has been reported to exhibit a wide spectrum of activity, including antioxidant activity. In this study, we evaluated the effect of hexane:ethanol (2:8) PL extract (subfraction of PL [SPL] extract) on GM-induced hair cell loss in basal, middle and apical regions in a neonatal cochlea cultures. METHODS: The protective effects of SPL extract were measured by phalloidin staining of cultures from postnatal day 2-3 mice with GM-induced hair cell loss. The anti-apoptosis activity of SPL extract was measured using double labeling by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and myosin-7a staining. The radical-scavenging activity of SPL extract was assessed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. RESULTS: SPL extract at a concentration of 1 microg/mL significantly inhibited GM-induced hair cell loss at basal and middle region of cochlea, while 5 microg/mL was effective against apical region hair cell loss. The protective effect of SPL extract was concentration dependent and hair cells retained their stereocilia in explants treated with SPL extract prior to treatment with 0.3 mM GM. SPL extract decreased GM-induced apoptosis of hair cells as assessed by TUNEL staining. The outer hair and inner hair counts were not decreased in SPL extract treated groups in compare to GM treated explants. Additionally, SPL extract showed concentration dependent radical scavenging activity in a DPPH assay. CONCLUSION: An anti-apoptosis effect and potent radical scavenger activity of SPL extract protects from GM-induced hair cell loss at basal, middle and apical regions in neonatal cochlea cultures.
Animals ; Apoptosis ; Asia ; Cochlea ; DNA Nucleotidylexotransferase ; Ear, Inner ; Ethanol* ; Gentamicins ; Hair* ; In Situ Nick-End Labeling ; Medicine, Traditional ; Mice ; Neurons ; Pacific Islands ; Phalloidine ; Piper* ; Reactive Oxygen Species ; Spices ; Stereocilia

Scrub typhus, an acute febrile illness caused by Orientia tsutsugamushi-induced vasculitis, is common in Korea, Asia and Pacific Islands. Endoscopic mucosal lesions or mucosal damages have rarely been reported in Scrub typhus. However, four cases of upper gastrointestinal bleeding, controlled by hemoclipping, in Tsutsugamushi-infected patients have been reported in Korea; although, no case of lower gastrointestinal bleeding in Scrub typhus has been reported. We experienced massive hematochezia in a 77-year-old female patient with Scrub typhus. Special studies, including upper gastroduodenoscopy, colonoscopy, abdominal CT scan, and SMA angiography were performed, but the focus of the bleeding could not be found. An RBC scan showed suspicious small bowel bleeding, but a capsule endoscopy could not reveal the focus of the bleeding focus; however, a colonoscopy showed active bleeding at the terminal ileum, with multiple ileal ulcerations. After conservative therapy, the patient's condition was stable and the hematochezia disappeared.
Aged ; Angiography ; Asia ; Capsule Endoscopy ; Colonoscopy ; Female ; Gastrointestinal Hemorrhage ; Hemorrhage* ; Humans ; Ileum ; Korea ; Pacific Islands ; Scrub Typhus* ; Tomography, X-Ray Computed ; Ulcer* ; Vasculitis

Dengue virus causes dengue fever and its more severe form, dengue hemorrhagic fever. The classical symptoms of dengue fever are high fever lasting for 5~7 days and bright reddish petechiae developed at the end of fever. The virus is transmitted by mosquitoes belonging to the genus Aedes, which are distributed in the tropical and subtropical areas of Africa, America, Southeast Asia, and Pacific islands. The currant pandemic of dengue viral infection began after the 1940s, possibly in consequence to the World War II, and the dengue virus infection has become the most important arthropod-borne viral infection. With an increase in the number of Koreans traveling to dengue fever-endemic areas since 1988, there has been an increase in the incidence of dengue viral infection and is reported to affect 50 to 90 patients annually. Further, it is the most common notifiable imported disease in Korea. Most of the patients with dengue infection presented with dengue fever or dengue hemorrhagic fever, and 1 fatal case of dengue shock syndrome was reported.
Aedes ; Africa ; Americas ; Asia, Southeastern ; Culicidae ; Dengue ; Dengue Hemorrhagic Fever ; Dengue Virus ; Fever ; Humans ; Incidence ; Korea ; Pacific Islands ; Pandemics ; Purpura ; Viruses ; World War II

Bacteria, pigs, rats, pots, plants, words, bones, stones, earrings, diseases, and genetic indicators of all varieties are markers and proxies for the complexity of interweaving trails and stories integral to understanding human movement and knowledge assemblage in Southeast Asia and around the world. Understanding human movement and knowledge assemblage is central to comprehending the genetic basis of disease, especially of a cancer like nasopharyngeal carcinoma. The problem is that the markers and trails, taken in isolation, do not all tell the same story. Human movement and knowledge assemblage are in constant interaction in an adaptive process of co-production with genes, terrain, climate, sea level changes, kinship relations, diet, materials, food and transport technologies, social and cognitive technologies, and knowledge strategies and transmission. Nasopharyngeal carcinoma is the outcome of an adaptive process involving physical, social, and genetic components.
Americas ; epidemiology ; Archaeology ; Asia, Southeastern ; epidemiology ; Biomarkers, Tumor ; analysis ; China ; epidemiology ; Emigration and Immigration ; Humans ; Knowledge ; Nasopharyngeal Neoplasms ; epidemiology ; etiology ; genetics ; Pacific Islands ; epidemiology

experience ; Tonga ; Health

Zika virus (ZIKV) was spread to both eastward and westward from Uganda where the virus was identified approximately in 1947 by a group of arbovirus researchers. In 2015, ZIKV reached Americas with major outbreaks in Brazil. Most countries with mosquito transmitted ZIKV infection are located in tropical and subtropical areas, where ZIKV is endemic with other flaviviruses, including JEV, dengue and yellow fever virus. Approximately 40 countries in Central and South Americas and territories in South Pacific Islands and South East Asia show autochthonous ZIKV endemics. American lineage of ZIKV is known significantly to be mutated in susceptibility to host and in pathogenicity from Asian and Asian lineages approximately since 2014. Early and specific identification of ZIKV infection is very important for the effective management of patients. First of all, optimal collection of specimens for the laboratory diagnosis is required for both nucleic acid testing (NAT) and serological tests. Specimens for NAT tests and serological tests should be determined by the available laboratory resources, work-flow in each laboratory and the geographic areas of specimen collected in addition to days after showing symptoms. Testing strategy for specific differentiation among flaviviruses will vary depending on the prevalence of viruses known to be circulating in the area where the patients were exposed. NAT will be employed for the patients presenting with onset of symptoms less than 7 days. Advanced diagnostic technologies should be continuously developed for the increase of specificity and sensitivity of ZIKV diagnosis.
Americas ; Arboviruses ; Asian Continental Ancestry Group ; Biology* ; Brazil ; Clinical Laboratory Techniques* ; Culicidae ; Dengue ; Diagnosis ; Disease Outbreaks ; Epidemiology* ; Far East ; Flavivirus ; Humans ; Pacific Islands ; Prevalence ; Sensitivity and Specificity ; Serologic Tests ; South America ; Uganda ; Virulence ; Yellow fever virus ; Zika Virus*

A population of 211 Melanesian babies born in Port Moresby after a known gestation were studied using the Dubowitz gestational assessment in order to assess the method in Melanesians. After exclusion of obvious outliers the regression equation for gestational age on total score was not significantly different from that of Dubowitz. Melanesian babies had relatively more mature neurological scores than external scores. The Dubowitz method of gestational assessment may be used without restandardization in a Melanesian population.
Gestational Age ; Humans ; Infant, Newborn ; Melanesia - ethnology ; Observer Variation ; Papua New Guinea

No abstract available.
Aircraft* ; DNA Fingerprinting ; Guam*