1.Photochemotherapy-induced Lentigines on a Vitiliginous Patch Electron Microscopic Observations.
Kwang Hoon LEE ; Dong Sik BANG ; Won Soo LEE
Yonsei Medical Journal 1988;29(1):66-71
Patients with vitiligo seem be less prone to the development of lentigines as a side effect of long-term photochemotherapy than do psoriatics. An 8-year-old boy who had a vitiliginous patch on his left thigh, had been receiving photochemotherapy since he was 2 years old. At the age of 3, multiple star-shaped brownish macules developed at the site of treatment. Photochemotherapy was continued until the patient was 6 year old, at which time no improvement in the vitiligo was seen, so photochemotherapy was discontinued. Now 2 years after treatment the lentigines still persist. On electron microscopic examination, the melanocytes showed two patterns of cell death: coagulative necrosis and apotosis together with atypical cytoplasmic and melanosomal alterations.
Case Report
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Child
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Human
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Lentigo/*etiology/pathology
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Male
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Melanocytes/ultrastructure
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Microscopy, Electron
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PUVA Therapy/*adverse effects
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Vitiligo/drug therapy