1.POEMS syndrome.
Moo Il KANG ; Kun Ho YOON ; Kwan Su HONG ; Bong Yun CHA ; Kwang Woo LEE ; Ho Young SON ; Sung Ku KANG
Journal of Korean Society of Endocrinology 1991;6(1):95-96
No abstract available.
POEMS Syndrome*
2.Recurrent Stroke as the Clinical Onset of POEMS Syndrome.
Zigao WANG ; Lu XIONG ; Hengbing ZU
Journal of Clinical Neurology 2017;13(2):199-200
No abstract available.
POEMS Syndrome*
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Stroke*
3.Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin abnormalities (POEMS) syndrome in a Filipino nurse returning to work following bortezomib treatment: A case report.
Nadine J. ENDAYA ; Raymond L. ROSALES
Journal of Medicine University of Santo Tomas 2022;6(2):1021-1026
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes) also known as Crow-Fukase syndrome or Takatsuki syndrome is a rare and disabling paraneoplastic syndrome that frequently occurs in the fifth or sixth decade of life without a known standard first-line therapy. A 34-year-old Filipino male nurse, who presented with gradually progressive distal lower extremity weakness and sharp shooting pain in bilateral legs accompanied by mild joint effusion on the left knee, hypertrichosis, bilateral conjunctival injection, and gynecomastia underwent extensive workup and was diagnosed with POEMS syndrome. Complete blood count revealed erythrocytosis and thrombocytosis with elevated serum VEGF (vascular endothelial growth factor) and elevated monoclonal serum free lambda light chains. The electrophysiologic studies revealed chronic demyelinating sensorimotor polyneuropathy while bone marrow core biopsy and bone marrow aspirate smear immunohistochemical staining showed it to be positive for lambda and CD138. He had an initial unsuccessful treatment course with melphalan and prednisone. Hence, bortezomib and dexamethasone were given which gave significant improvement in symptoms from the overall neuropathy limitation score of 5 to 1.
Poems Syndrome|bortezomib|dexamethasone
4.How I diagnose and treat POEMS syndrome.
Chinese Journal of Hematology 2019;40(5):368-371
5.Glomeruloid Hemangioma as a Marker for the Early Diagnosis of POEMS Syndrome.
Jin Yong LEE ; Jae Kyun CHOI ; Jae Won HA ; So Eun PARK ; Chul Woo KIM ; Sang Seok KIM
Annals of Dermatology 2017;29(2):249-251
No abstract available.
Early Diagnosis*
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Hemangioma*
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POEMS Syndrome*
6.Postoperative pulmonary edema in a patient with POEMS syndrome.
Yoonji JO ; Jee Eun CHANG ; Seokha YOO ; Jin HUH
Korean Journal of Anesthesiology 2013;65(6 Suppl):S82-S83
No abstract available.
Humans
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POEMS Syndrome*
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Pulmonary Edema*
7.Advance in diagnosis and treatment of POEMS syndrome.
Chinese Journal of Hematology 2012;33(10):881-883
Humans
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POEMS Syndrome
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diagnosis
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therapy
8.POEMS Syndrome: Two Cases Report.
Eun Young KO ; Ik YANG ; Kyung Won LEE ; Yul LEE ; Soo Young CHUNG ; Eil Seoung LEE
Journal of the Korean Radiological Society 1998;39(1):169-172
Two patients with an unusual multisystemic syndrome characterized by polyneuropathy, organomegaly(especiallyhepatosplenomegaly), endocrine dysfunction, M-protein, and skin abnormalites(POEMS syndrome) are discussed.Characteristic radiographic features include hepatosplenomegaly, lymph node enlargement, sclerotic bony lesions,and a peculiar variety of bony proliferation.
Humans
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Lymph Nodes
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POEMS Syndrome*
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Polyneuropathies
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Skin
9.Diagnostic performance and clinical correlation of serum vascular endothelial growth factor levels in patients with newly diagnosed POEMS syndrome.
Xinxin CAO ; Chen WANG ; Hao CAI ; Minghui DUAN ; Wei ZHANG ; Tianjiao LI ; Daobin ZHOU ; Jian LI
Chinese Journal of Hematology 2014;35(12):1065-1068
OBJECTIVETo evaluate the diagnostic performance and clinical correlation of serum vascular endothelial growth factor (VEGF) in patients with newly diagnosed POEMS syndrome.
METHODSWe recruited 104 patients with POEMS syndrome who diagnosed at Peking Union Medical College Hospital during October 2010 to April 2014 in the current study. Clinical data and serum samples were collected. Serum VEGF levels were measured, comparing to both disease and healthy controls, and its correlation with clinical features were analyzed.
RESULTSPatients with newly diagnosed POEMS syndrome showed markedly elevated levels of serum VEGF (median 3503 ng/L, P<0.01). A cut-off value of 1 200 ng/L had a specificity of 90.2%, with a sensitivity of 83.7%, in support of a POEMS diagnosis. Further analyses indicated that patients with higher serum VEGF level (>2 000 ng/L) had more prevalent osteosclerosis (61.0% vs 37.0%, P=0.031) and papilledema (70.1% vs 44.4%, P=0.017).
CONCLUSIONSerum VEGF level was useful in differentiating POEMS syndrome from other disorders with overlapping clinical presentations, and its levels correlated with several disease features.
Humans ; POEMS Syndrome ; Vascular Endothelial Growth Factor A
10.A Case of POEMS Syndrome-Renal Involvements of POEMS Syndrome in Korea.
Young Il KWON ; Joo Hark YI ; Ji Eun KIM ; Chi Un CHOI ; Sang Woong HAN ; Moon Hyang PARK ; Ho Jung KIM
Korean Journal of Nephrology 2006;25(4):621-628
Renal involvements of POEMS syndrome are not rare. In some reports, almost 50% of patients show proteinuria. There are some case reports of renal involvement in POEMS syndrome in Korea, but there are no reports about clinical features of renal involvement in POEMS syndrome in Korea and its frequency. We report a case of POEMS syndrome with nephropathy and clinical features of renal involvement in POEMS syndrome in Korea. The most frequent symptoms in POEMS syndrome in Korea were polyneuropathy, edema and ascites. Renal involvement was found in 40% of patients. If there were unknown cause of edema and renal failure when combined with polyneuropathy, considerations should be taken into patients for POEMS syndrome even though POEMS syndrome is very rare.
Ascites
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Edema
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Humans
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Korea*
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POEMS Syndrome*
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Polyneuropathies
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Proteinuria
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Renal Insufficiency