Objective: To understand the status of non-suicidal self-injury (NSSI) among Zhuang middle school students and its association with internet addiction, and to provide support for the effective prevention of unhealthy behaviors among Zhuang middle school students. Methods: From March to June 2018, 14 822 Zhuang middle school students were selected from 8 cities in Guangxi to conduct a questionnaire survey, including demographic information, family status, NSSI, internet addiction, and psychological status. Results: The proportion of NSSI among middle school students in Zhuang nationality was 30.54%; the proportion of occasional and frequent NSSI was 18.24% and 12.30%, respectively. The proportion of Zhuang middle school students with internet addiction was 1.82%, and those with suspected Internet addiction was 29.77%. Non-suicidal self-injury behaviors were statistically significant in different grades, whether the only-child in the family, family income, family type, parenting style, family history of mental illness, and Internet addiction(χ2=5.67, 34.25, 73.39, 16.12, 116.71, 10.66, 294.48, P<0.05). Regression analysis showed that middle school students (OR=0.53) and non-only children (OR=0.79) were more likely to have non-suicidal self-injury behaviors. Family income ≥5 000 yuan per month(OR=1.49), joint family(OR=1.98), intergenerational family(OR=1.30), education method with neglect(OR=1.35), family history of mental illness(OR=1.29), suspected internet addiction(OR=1.65), and internet middle school students with an addiction(OR=1.96) were more likely to have non-suicide suicide. Conclusion Zhuang middle school students have serious non-suicide suicide behaviors, which is closely associated with internet addiction. In the future, non-suicide suicide behaviors can be reduced through internet addiction prevention.