1.Туршилтын Амьтанд Үүсгэсэн Артритын Эмгэг Загварын Үеийн Антиоксидант Тогтолцооны Алдагдалд Уламжлалт Лидэр-5 Тангийн Үзүүлэх Нөлөө
Sukhee Z ; Khishigjargal S ; Molor-Erdene P ; Uuganbayar B
Journal of Oriental Medicine 2015;9(2):17-23
Abstracts Traditional drug Lider-5 traditional medicine, rheumatism
and arthritis disease which has been used experimental animals we
created arthritis disease antioxidant system of the Lider-5 studied
the impact of the loss. As a result of the research that you created
via a test animal collagen II arthritis pathological articular tissues
and blood plasma contained malondialidyegid In addition to
reducing the antioxidant Glutathione is provided a system of the
body, including supyeroksidismutaza enzymes to increase the
amount of influence. As you can see in the traditional drug Lider-5
disorders antioxidant system, loss prevention, and treatment is
effective, the effects of its ingredients contained Tinospora sinensis,
Gentiana decumbens, such as antioxidant effect might be
associated with key plant attendant substances.
2.AntinociceptiveEffects Of The Of Deva-5 Decoction Used In Traditional Medicine In Mice
Munkh-Undrakh N ; Molor-Erdene P
Journal of Oriental Medicine 2013;4(1):58-63
Antinociceptive effect of Deva-5 (Gentiana decumbens L.,
Terminalia Chebula Retz., Polygonium bistorta L., Momordica
cochinchinensis Lour., Chiazospermum erectum Bernh) used in
traditional medicine for treatment of infectious heat disease was
examined in both chemically- and temperature-induced pain models
of mice. Deva-5 administered orally at 100 and 200 mg/kg
significantly reduced the writhings induced by acetic acid from
control values of 37.7±6.7 (N = 6) to 24.5±3.9 (N = 6) and 18,8±2,8
(N = 6), respectively (p<0.05). When administered at 100 and 200
mg/kg, Deva-5 reduced the paw licking time for the second phase of
the formalin test from the control value of 92.6±12.9 s (N = 6) to
69.8±5.7 s (N = 6) and 70.1±11.7 s (N = 6), respectively (p<0.05).
Deva-5 had no significant effect on the first phase of the formalin
test. As evaluated by the tail immersion test, Deva-5 at doses of 100
and 200 mg/kg, showed no analgesic activity. These results show
that Deva-5 has antinociceptive activity and suggest that this effect
is probably an indirect anti-inflammatory effect, which does not
involve the central nervous system.
3.Аnti-inflammatory activities of traditional Mongolian drug garidi-5
Uuganbayar B ; Ariunaa Z ; Oldokh S ; Chimedragchaa CH ; Munkhzul G ; Sugarjav E ; Molor-Erdene P
Mongolian Medical Sciences 2013;165(3):61-65
Introduction. Garidi-5, a traditional medicine composed of 5 herbs including Terminalia chebula Retz., Aconitum Kusnezoffii Reichb., Acorus calamus L., Saussurea lappa L., and musk of Moschus moschiferus, has been used in traditional Mongolian medicine as an analgesic and antibacterial medicine. The present work was undertaken to evaluate the traditional drug Garidi-5 for its analgesic and anti-inflammatory activity.Materials and Methods. The method of Winter et al. was used to study acute inflammation. Rats in groups of five each were treated with vehicle, Garidi-5 (20, 80 and 200 mg/kg, p.o.) and Indometacin (10 mg/kg) one hour prior to Carrageenan injection. 0.1 ml of 1% Carrageenan was injected into the subplantar tissue of left hind paw of each rat. Swelling of carrageenan injected foot was measured at 0, 0.5, 2, 4 h using Plethysmometer (UGO Basile, Italy)). The right hind paw was injected with 0.1 ml of vehicle.Results. The Garidi-5 (20, 80 and 200 mg/kg) significantly (P<0.01) inhibited carrageenan induced rat paw edema as compared to control group. Maximum inhibition of paw edema was observed with Garidi- 5 (80 and 200 mg/kg) at 4 h when compared to the control group (Tab.1). In assay data, the TNF-α, IL-1β and IL-6 secretion in serum were highly elevated by carrageenan induction but administration of Garidi-5 signifi cantly reduced serum secretion of inflammatory mediatorsas compared to vehicle group (Tab. 2).Conclusion. In conclusion, Traditional drug Garidi-5 have anti-in flammatory properties. The potential efficacy of Garidi-5 to treat inflammation is based in a part on the hy pothesis that it will suppress the proinflammatory cytok ines resulting in less oedema.
4.Аnti-inflammatory activities of traditional mongolian drug garidi-5
Uuganbayar B ; Ariunaa Z ; Oldokh S ; Chimedragchaa CH ; Munkhzul G ; Sugarjav E ; Molor-Erdene P
Mongolian Medical Sciences 2013;166(4):52-56
Introduction. Garidi-5, a traditional medicine composed of 5 herbs including Terminalia chebula Retz. Aconitum Kusnezoffii Reichb., Acorus calamus L., Saussurea lappa L., and musk of Moschus moschiferus, has been used in traditional Mongolian medicine as an analgesic and antibacterial medicine. The present work was undertaken to evaluate the traditional drug Garidi-5 for its analgesic and anti-inflammatory activity.Materials and Methods. The method of Winter et al. was used to study acute inflammation. Rats in groups of five each were treated with vehicle, Garidi-5 (20, 80 and 200 mg/kg, p.o.) and Indometacin (10 mg/kg) one hour prior to Carrageenan injection. 0.1 ml of 1% Carrageenan was injected into the subplantar tissue of left hind paw of each rat. Swelling of carrageenan injected foot was measured at 0, 0.5, 2, 4 h using Plethysmometer (UGO Basile, Italy)). The right hind pawwas injected with 0.1 ml of vehicle.ResultsThe Garidi-5 (20, 80 and 200 mg/kg) significantly (P<0.01) inhibited carrageenan induced rat paw edema as compared to control group. Maximum inhibition of paw edema was observed with Garidi-5 (80 and 200 mg/kg) at 4 h when compared to the control group (Tab.1). In assay data, the TNF-α, IL-1β and IL-6 secretion in serum were highly elevated by carrageenan induction but administration of Garidi-5 signifi cantly reduced serum secretion of inflammatory mediators as compared to vehicle group (Tab. 2). ConclusionIn conclusion, Traditional drug Garidi-5 have anti-in flammatory properties. The potential efficacy of Garidi-5 to treat inflammation is based in a part on the hy pothesis that it will suppress the proinflammatory cytok ines resulting in less oedema.
5.The study of some theoretical concepts of pulse reading method in traditional Mongolian medicine
Chen Yu Lin ; Molor-Erdene P ; Bold Sh
Mongolian Pharmacy and Pharmacology 2020;16(1):35-39
Introduction
Traditional Mongolian medicine pulse diagnosis is one of the three major assessments in consultation. Possessing thorough pulse feeling skill, the main diagnostic method of traditional medicine,
makes a direct impact to treatment results. Unfortunately, there has not been much research done
on determining the scientific nature of the pulse feeling diagnostic method in Mongolia. Therefore,
the topic was selected in order to clarify some issues of history and theory of the pulse feeling method and to prove the method with practical application.
Highlight some of the theoretical concepts of the traditional medicine approach to pulse reading.
When feeling the pulse, the index finger is pressed lightly to feel the skin, the middle finger is
pressed with medium pressure to feel the muscle tissue and the ring finger is pressed hard to feel
the bone of the doctor is pressed lightly in order to distinguish the twisted blood flow changes overcoming the resistance of sequential pressure. We also identified that the pulse feeling is based on
the nature and connection of the wind and blood and their actions in regard to traditional medicine,
whereas by modern medical theory; it is based on functioning factors of vascular muscle layers,
pulse rate, pressure to vascular wall and condition of vascular wall as well as thickness and thinness of blood flow. In addition to the method being effective when detecting pregnancy and gender
of fetus of patients at the maternity hospital, it is definite that it can be basis of identifying the characteristic of pulse of warm and cold diseases.
6.Treatment methods of eye disease in the “Ngo Mtshar Dga’ Ston Gter Mdzod”
Wanglin ; Enkhjin G ; Molor-Erdene P ; Bold Sh
Mongolian Pharmacy and Pharmacology 2020;16(1):40-44
Abstract
Prescriptions of Iron decoction-5, Brightness-7 mixed medicine, Sun-17 and Brightness-30 are used
in practice in Inner Mongolian Autonomous Region of China. However these prescriptions are just a
few of the medicines used for eye diseases and there are dozens of unexplored prescriptions. The
source study of traditional medicine is the main research direction to facilitate this kind of research.
We have examined the treaatmen methods of eye diseases from the book gso rig gzhung mang
bsdus pa'i bdud rtsi'i snying po tsha grang zug rngu sel ba'i ngo mtshar dga' ston gter mdzod zhes
bya ba bzhugs so by Choijamts. The study found that the main cause of eye disease is damage in
one or combination of wind, bile, phlegm, blood and identified several interesting prescriptions and
interpreted its names in Mongolian, including mun sel nyi ma'i dkyil 'khor, a gar mchog bdun, gsal
byed bcu gsum, ring srel phan byed, rdo rje khrag 'joms. In addition, eye diseases were generally
treated by mun sel nyi ma'i dkyil 'khor, a gar mchog bdun, gsal byed bcu gsum, ring srel phan byed,
rdo rje khrag 'joms decoctions.
There are a number of interesting methods of treating eye diseases within the one scripture used in
the study, and furthermore it is necessary to further study each of these methods and to introduce
them into curriculum of ophthalmology of traditional medicine subject.
7.Literature Review On Effect Of Ingredients Of Churu-5, A Bhutanese Traditional Concoction On Diabetes Mellitus
Jurmie chodena ; Molor-Erdene P ; Tsend-Ayush D
Journal of Oriental Medicine 2014;6(1):17-17
Background:This study reports a literature review aimed to assess studies related to
the efficacy of various herbs in diabetes mellitus used in Bhutan. The incidence of
Diabetes Mellitus is rising and many of the diabetics frequently use herbal
treatments along with modern medical treatment for glyceamic control and
improving their well-being. Methods: An electronic database (Pub med) was
searched for 2002-2014 period and 31 related articles were assessed. Result:
Many studies-mostly animal trials- have been conducted in this field. Among the
herbs, we searched for Phyllantus emblica Linn., Curcuma longa Linn., Berberies
aristata Berberidaceae, Tribulus terristries Linn., and Thlaspi arvense Linn. Their
chemical compositions, ethno medical uses and anti diabetic activities were
summarized. In the search using the keywords ‘phyllantus emblica and diabetes
mellitus’’ 19 articles were found. Likewise 48 articles were found with the keyword
‘curcuma longa and diabetes mellitus’ but only 45 articles were of within 2002. 2
articles were found with the keywords ‘berberies aristata and diabetes mellitus’ and
4 articles with ‘tribulus terristries and diabetes mellitus’. As for the ‘thlaspi arvense
and diabetes mellitus’ no articles were available. Conclusion: Almost all ingredients
of Churu-5 showed effective result in the study done by others.
8.Study Of Action Of Modification Of Some Animal-Originated Medicines Based On Traditional Principles Of Diet Therapy
Alimaa T ; Chimedragchaa Ch ; Tumurbaatar N ; Molor-Erdene P
Journal of Oriental Medicine 2012;3(2):58-58
Introduction: Diet therapy is based on body constitution, disease
conditions and seasonal influences in traditional medicine.
Traditional principles of disease treatment and prevention with
diet can be combined with conventional medical practices and
may lead to a possibility of developing new treatment and
preventive strategies.
Objectives: To study the effects of interconnected factors of diet
and season on some pathological changes of organ systems, we
examined the effect of horse meat which has hot quality and
goat meat which has cold quality on rat models of acute hepatitis
induced by CCL4 and acute pulmonary edema induced by
adrenalin hydrochloride in the spring and autumn.
Materials and methods: CCL4 (200 mg/kg) was administered
percutaneously to induce acute hepatitis in rats. Adrenalin
hydrochloride (25 mg/kg) injected via the tail vein by slow
injection to induce acute pulmonary edema in mice. Horse and
goat meat were given for 14 days before the CCL4 and
adrenalin hydrochloride administration. Renal activity was
determined by measuring urine volume every 6 hours.
Results: Results of our study show that goat meat which has
cold quality is more effective in the autumn when a rise of bile
element is occurred, and horse meat which has a cold quality is
more effective in the autumn when phlegm element rises. Horse
meat increased pulmonary surfactant stability coefficient by
54.73% in the autumn while it increased that by 69.66% in the
spring. Decreased alveolar collapse and improved pulmonary
surfactant stability by horse meat treatment support the concept
of traditional medicine that diseases of the lungs, phlegm
dominant organs are treated with diet, medicine, and behavior
with warm and oily qualities. In the spring, urine excretion was
increased in animals treated with goat meat which has cold and
oily qualities.
Conclusions: 1. The “spring + horse meat” and “autumn + goat
meat” versions of treatments more effectively decrease cytolysis
during acute hepatocellular necrosis in animals administered
CCL4. 2. Compare to goat meat, horse meat has more effects to
decrease alveolar collapse and pulmonary edema in mice model
of pulmonary edema induced by adrenalin hydrochloride. 3.
“Goat meat + spring” version of treatment decreases urine
excretion in experimental animals.
9.Study Of Some Traditional Drugs Based On Calcite Processed By Traditional Technology
Seesregdorj S ; Molor-Erdene P ; Ariunjargal N ; Dorjbat S ; Soyolt S ; Tsendjav D
Journal of Oriental Medicine 2012;3(2):59-59
In traditional Mongolian Medicine, materials derived from plants,
animals, trees, and minerals are processed by traditional
technology to improve their effectiveness and safety. One of
mineral-based materials is calcite which is widely used in
traditional medicine.
Mineral contents of calcite: After processing by traditional
technology (taming) with enrichment, calcite turns to bright
yellow, small soft microcrystals with bitter taste and smell of milk.
Moreover it obtains solubility in water.
Various macro- and microelements were determined in tamed
calcite including Na, Mg, K, Ca, S, Mn, and Fe. Ca takes the
major part (64%) of the elements.
Crystal size determined by NANOPHOX (PCCS), GmbH,
Sympatec apparatus were 115 nm and 124 nm depending on
the traditional technology of processing.
Crystal structure of calcite in phase shifts was analyzed after
burning it in +300º C, +500 º C, +800 º C, +1200 º C, and +1400
º C by using Shimadzu XRD-7000 X-ray diffractometer, HA-
1001, and TTK-450 apparatus. CaCO3 content (84.23%) was
higher at +300º C and +500 º C, while CaC2 content (15.77%)
was higher at +800 º C, +1200 º C, and +1400 ºC.
Effects of calcite on acetic acid-induced gastric ulcer: Gastric
ulcer induced by acetic acid in rats was healed completely by
tamed calcite within 21 days. Calcite improves bone repair of
experimental fracture in rats by increasing Ca and alkaline
phosphatase activities.
Effects of calcite containing drug Jonsh-5 on experimental femur
fracture in rabbits: Jonsh-5 is composed of 5 components
including calcite, Cardius crispus, Forsythia suspense,
Terminalia Chebula, and Inula helenium. Jonsh-5 increased
serum level of alkaline phosphatase after 7 days of fracture. X-
ray images showed that healing process of the bone was
significantly increased by Jonsh-5 compare to control and
Calcium D3-Nycomed treatment. These results were also proved
by histological analysis suggesting that Jonsh-5 may promote
bone healing in rat model of fracture.
Safety of calcite containing drugs: Contents of macro- and
microelements, moisture, and substances extractable in water
have been determined. Mineral and organic impurities have also
been evaluated in Jonsh-5. Bacterial impurity of the drug is
within the standard range. Moreover contents of heavy metals
such as lead, cadmium, and mercury meat the WHO permeated
levels of toxic metals.
10.Аnalgesic Activities Of Traditional Mongolian Drug Garidi-5
Uuganbayar B ; Ariunaa Z ; Oldokh S ; Chimedragchaa Ch ; Sugarjav E ; Molor-Erdene P ; Munkhzul G
Journal of Oriental Medicine 2013;4(1):64-70
Garidi-5, a traditional medicine composed of 5 herbs including
Terminalia chebula Retz., Aconitum Kusnezoffii Reichb., Acorus
calamus L., Saussurea lappa L., and musk ofMoschus moschiferus,
has been used in traditional Mongolian medicine as an analgesic and
antibacterial medicine. The aim of the study was to evaluate the
central and peripheral analgesic action of traditional mongolian drug
Garidi-5 in experimental animal models. Analgesic activity was
assessed by tail flick method (for central action) and l acetic acid-
induced writhing test (for peripheral action). Garidi-5 extract (20
mg/kg, 80, 200mg/kg p.o.) and aspirin (100 mg/kg) showed
significant peripheral analgesic activity (p<0.05). Garidi-5 extract (20
mg/kg, 80, 200mg/kg p.o.) and Morphin (10 mg/kg, i.p.) also showed
significant central analgesic activity (p<0.05). Conclusion: Biological
activity substances were detected in the Traditional drug Garidi-5.
Traditional drug Garidi-5 has analgesic effects.