Introduction. Garidi-5, a traditional medicine composed of 5 herbs including Terminalia chebula Retz., Aconitum Kusnezoffii Reichb., Acorus calamus L., Saussurea lappa L., and musk of Moschus moschiferus, has been used in traditional Mongolian medicine as an analgesic and antibacterial medicine. The present work was undertaken to evaluate the traditional drug Garidi-5 for its analgesic and anti-inflammatory activity.Materials and Methods. The method of Winter et al. was used to study acute inflammation. Rats in groups of five each were treated with vehicle, Garidi-5 (20, 80 and 200 mg/kg, p.o.) and Indometacin (10 mg/kg) one hour prior to Carrageenan injection. 0.1 ml of 1% Carrageenan was injected into the subplantar tissue of left hind paw of each rat. Swelling of carrageenan injected foot was measured at 0, 0.5, 2, 4 h using Plethysmometer (UGO Basile, Italy)). The right hind paw was injected with 0.1 ml of vehicle.Results. The Garidi-5 (20, 80 and 200 mg/kg) significantly (P<0.01) inhibited carrageenan induced rat paw edema as compared to control group. Maximum inhibition of paw edema was observed with Garidi- 5 (80 and 200 mg/kg) at 4 h when compared to the control group (Tab.1). In assay data, the TNF-α, IL-1β and IL-6 secretion in serum were highly elevated by carrageenan induction but administration of Garidi-5 signifi cantly reduced serum secretion of inflammatory mediatorsas compared to vehicle group (Tab. 2).Conclusion. In conclusion, Traditional drug Garidi-5 have anti-in flammatory properties. The potential efficacy of Garidi-5 to treat inflammation is based in a part on the hy pothesis that it will suppress the proinflammatory cytok ines resulting in less oedema.

Introduction Traditional Mongolian medicine pulse diagnosis is one of the three major assessments in consultation. Possessing thorough pulse feeling skill, the main diagnostic method of traditional medicine, makes a direct impact to treatment results. Unfortunately, there has not been much research done on determining the scientific nature of the pulse feeling diagnostic method in Mongolia. Therefore, the topic was selected in order to clarify some issues of history and theory of the pulse feeling method and to prove the method with practical application.
Highlight some of the theoretical concepts of the traditional medicine approach to pulse reading. When feeling the pulse, the index finger is pressed lightly to feel the skin, the middle finger is pressed with medium pressure to feel the muscle tissue and the ring finger is pressed hard to feel the bone of the doctor is pressed lightly in order to distinguish the twisted blood flow changes overcoming the resistance of sequential pressure. We also identified that the pulse feeling is based on the nature and connection of the wind and blood and their actions in regard to traditional medicine, whereas by modern medical theory; it is based on functioning factors of vascular muscle layers, pulse rate, pressure to vascular wall and condition of vascular wall as well as thickness and thinness of blood flow. In addition to the method being effective when detecting pregnancy and gender of fetus of patients at the maternity hospital, it is definite that it can be basis of identifying the characteristic of pulse of warm and cold diseases.

Abstract Prescriptions of Iron decoction-5, Brightness-7 mixed medicine, Sun-17 and Brightness-30 are used in practice in Inner Mongolian Autonomous Region of China. However these prescriptions are just a few of the medicines used for eye diseases and there are dozens of unexplored prescriptions. The source study of traditional medicine is the main research direction to facilitate this kind of research. We have examined the treaatmen methods of eye diseases from the book gso rig gzhung mang bsdus pa'i bdud rtsi'i snying po tsha grang zug rngu sel ba'i ngo mtshar dga' ston gter mdzod zhes bya ba bzhugs so by Choijamts. The study found that the main cause of eye disease is damage in one or combination of wind, bile, phlegm, blood and identified several interesting prescriptions and interpreted its names in Mongolian, including mun sel nyi ma'i dkyil 'khor, a gar mchog bdun, gsal byed bcu gsum, ring srel phan byed, rdo rje khrag 'joms. In addition, eye diseases were generally treated by mun sel nyi ma'i dkyil 'khor, a gar mchog bdun, gsal byed bcu gsum, ring srel phan byed, rdo rje khrag 'joms decoctions.
There are a number of interesting methods of treating eye diseases within the one scripture used in the study, and furthermore it is necessary to further study each of these methods and to introduce them into curriculum of ophthalmology of traditional medicine subject.

Introduction. Garidi-5, a traditional medicine composed of 5 herbs including Terminalia chebula Retz. Aconitum Kusnezoffii Reichb., Acorus calamus L., Saussurea lappa L., and musk of Moschus moschiferus, has been used in traditional Mongolian medicine as an analgesic and antibacterial medicine. The present work was undertaken to evaluate the traditional drug Garidi-5 for its analgesic and anti-inflammatory activity.Materials and Methods. The method of Winter et al. was used to study acute inflammation. Rats in groups of five each were treated with vehicle, Garidi-5 (20, 80 and 200 mg/kg, p.o.) and Indometacin (10 mg/kg) one hour prior to Carrageenan injection. 0.1 ml of 1% Carrageenan was injected into the subplantar tissue of left hind paw of each rat. Swelling of carrageenan injected foot was measured at 0, 0.5, 2, 4 h using Plethysmometer (UGO Basile, Italy)). The right hind pawwas injected with 0.1 ml of vehicle.ResultsThe Garidi-5 (20, 80 and 200 mg/kg) significantly (P<0.01) inhibited carrageenan induced rat paw edema as compared to control group. Maximum inhibition of paw edema was observed with Garidi-5 (80 and 200 mg/kg) at 4 h when compared to the control group (Tab.1). In assay data, the TNF-α, IL-1β and IL-6 secretion in serum were highly elevated by carrageenan induction but administration of Garidi-5 signifi cantly reduced serum secretion of inflammatory mediators as compared to vehicle group (Tab. 2). ConclusionIn conclusion, Traditional drug Garidi-5 have anti-in flammatory properties. The potential efficacy of Garidi-5 to treat inflammation is based in a part on the hy pothesis that it will suppress the proinflammatory cytok ines resulting in less oedema.

Proteomic tools were used to identify the key proteins that might be associated with bronchial asthma(BA). Firstly, the serum samples from healthy adults and asthmatic patients were collected. Tandem Mass Tag~(TM)(TMT), which removes high-abundance structures and nonspecific proteins, was employed to identify the differentially expressed proteins between asthmatic patients and healthy adults. Gene Ontology(GO) annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis were carried out for the differentially expressed proteins. The core proteins in the asthma group were screened out by protein-protein interaction(PPI) analysis. Then the core proteins were verified by Western blot for 3 patients with bronchial asthma and 3 healthy adults. A total of 778 differentially expressed proteins were screened out, among which 32 proteins contained quantitative information, including 18 up-regulated proteins and 14 down-regulated proteins. The differentially expressed proteins were enriched in 28 KEGG signaling pathways. The PPI analysis showed that 10 proteins(GDN, 1433 Z, VWF, HEMO, CERU, A1 AT, TSP1, G3 P, IBP7, and KPYM) might be involved in the pathogenesis of bronchial asthma. Compared with those in healthy adults, the expression levels of SLC25 A4, SVEP1, and KRT25 in the sera of asthmatic patients were up-regulated(P<0.05). Therefore, it is hypothesized that a variety of immune signaling pathways and differentially expressed proteins play a role in the pathogenesis of BA, which provides potential target information for the treatment of BA.
Adult ; Humans ; Proteomics ; Gene Ontology ; Proteins ; Disease Susceptibility ; Asthma/genetics*