<p>OBJECTIVEClinical effects in local application of hyaluronic acid (HA) adjunctive to scaling and root planing (SRP) were evaluated.p><p>METHODSIn this cross over design study 20 patients with chronic periodontitis were included. Plaque index, sulcus-fluid-flow-rate (SFFR), sulcus bleeding index, probing pocket depth and attachment level were monitored. All patients were treated with full mouth SRP, in addition a HA gel was administered subgingivally in the test site every week for 6 weeks.p><p>RESULTSA statistically significant improvement of all clinical test parameters was observed in both groups (P < 0.05). Clinically, no significant difference between test and control group could be found. However, the SFFR decreased significantly faster in the test group.p><p>CONCLUSIONNo post-inflammatory tissue regeneration could be achieved by the adjunctive use of HA gel to SRP in the patients with chronic periodontitis. Due to SFFR a control of local inflammation can be achieved quickly.p>
Adult ; Aged ; Chronic Disease ; Dental Scaling ; Female ; Humans ; Hyaluronic Acid ; therapeutic use ; Male ; Middle Aged ; Periodontal Pocket ; Periodontitis ; drug therapy ; Root Planing