Oncocytic lipoadenoma is a rare tumor, with only 18 cases having been reported since the first in 1998. We encountered a case of oncocytic lipoadenoma presenting as a slowly growing parotid mass in a 71-year-old man. This tumor is characteristically comprised of a mixture of oncocytes and adipocytes. The present case is one of five reported cases of oncocytic lipoadenoma showing sebaceous differentiation. The results of immunohistochemical study with DOG1 antibody supported the origination of this tumor in the striated duct.
Adipocytes ; Aged ; Humans ; Oxyphil Cells ; Parotid Gland*

Metastatic hepatocellular carcinoma of the ovary is an extremely rare ovarian tumors and may cause a diagnostic problem. This tumor was first described by Ooartman and Elliot in 1983. The differential diagnosis in cases of hepatocellular carcinoma metastatic to the ovary is with primary and metastatic hepatoid tumors of the ovary and diverse other tumors of the ovary composed of oxyphil cells, which may be primary or metastatic. We have experienced one case of metastatic hepatocellular carcinoma of the ovary with brief review of the literature.
Carcinoma, Hepatocellular* ; Diagnosis, Differential ; Female ; Ovary* ; Oxyphil Cells

Renal oncocytomas are neoplasms consisting of oncocytes, which are large epithelial cells with finely granular eosinophilic cytoplasm. The incidence of these tumors are unknown and exceedingly rare but believed to range between 5 and 10% of renal cortical tumors. Although renal oncocytomas are considered benign neoplasms, they are difficult to differentiate from renal cell carcinomas and easily misdiagnosed as carcinomas. We report a case that are indistinguishable from renal cell carcinoma preoperatively and another case showing apparently benign nature, despite its large size, 17 x 15cm and 8 years long history. So a provisional diagnosis of renal oncocytoma was made after renal computed tomography demonstrated characteristic appearance of this tumor and the diagnosis was confirmed with electron microscopy.
Adenoma, Oxyphilic* ; Carcinoma, Renal Cell ; Cytoplasm ; Diagnosis ; Eosinophils ; Epithelial Cells ; Incidence ; Microscopy, Electron ; Oxyphil Cells

Oncocytoma is a neoplasm consisting of oncocytes that is found in the salivary gland, kidney, and thyroid. Adrenocortical oncocytoma is particularly uncommon, and most cases reported are benign and nonfunctioning. Here, we report a 20 cm adrenal mass associated with necrosis that was identified as an oncocytic adrenocortical tumor with uncertain malignant potential through histopathological evaluation after its resection.
Adenoma, Oxyphilic ; Adrenal Gland Neoplasms ; Kidney ; Necrosis ; Oxyphil Cells ; Salivary Glands ; Thyroid Gland ; Uncertainty

Melanotic oncocytic metaplasia of the nasopharynx is a rare condition which is characterized by the presence of usually a small, brown to black colored pigmented lesion around the Eustachian tube opening. Although it is a benign lesion, it may be clinically misdiagnosed as malignant melanoma. Microscopically, melanotic oncocytic metaplasia is a combination of oncocytic metaplasia of the epithelium of the gland and melanin pigmentation in its cytoplasm. In our present study, we report three cases of melanotic oncocytic metaplasia of the nasopharynx. All the three cases occurred in men and were presented as multiple black pigmented lesions around the torus tubarius. Microscopically, mucous glands with diffuse oncocytic metaplasia and numerous black pigments were observed. No cellular atypia was observed. Immunohistochemically, the scattering of S-100 protein-positive, and human melanoma black 45-negative dendritic melanocytes was evident. This is the first report of cases of melanotic oncocytic metaplasia of the nasopharynx in Korea.
Cytoplasm ; Epithelium ; Eustachian Tube ; Humans ; Korea ; Male ; Melanins ; Melanocytes ; Melanoma ; Metaplasia ; Nasopharynx ; Oxyphil Cells ; Pigmentation

Adrenal oncocytomas are very rare. Because most of them are benign and nonfunctioning, they are detected incidentally. Here, we report a case of nonfunctioning benign adrenocortical oncocytoma located in the left adrenal gland in a 54-year-old man who presented with no symptoms. The tumor was 4.5 x 3 x 3 cm in size and was predominantly composed of oncocytes, which exhibited abundant eosinophilic granular cytoplasm and were arranged with a nested or diffuse architecture without capsular or vascular invasion. Nuclear atypia and mitotic figures were not observed. A discussion of this case and a review of recent updates in the literature are presented. In patients with adrenocortical oncocytomas, treatment is similar to that for adrenocortical neoplasia. However, due to the risk of over-diagnosis of malignancy, and the better clinical outcomes associated with adrenocortical oncocytoma, more attention should be paid to the diagnosis of adrenocortical oncocytoma.
Adenoma, Oxyphilic ; Adrenal Glands ; Adrenocortical Adenoma ; Cytoplasm ; Eosinophils ; Humans ; Oxyphil Cells

Aged ; Female ; Humans ; Male ; Melanosomes ; Metaplasia ; Middle Aged ; Nasopharynx ; cytology ; pathology ; Oxyphil Cells ; cytology

Adult ; Female ; Humans ; Maxillary Sinus Neoplasms ; pathology ; Nasal Cavity ; pathology ; Oxyphil Cells ; Papilloma ; pathology

The increased use of thyroid fine needle aspiration (FNA) has refocused on Hurthle cell lesions. The cytologic diagnosis of Hurthle cell tumor is a challenge due to the presence of Hurthle cells in non-neoplastic lesions and the inability to differentiate between benign and malignant Hurthle cell tumor. We report a case of Hurthle cell adenoma(HCA) in a 68-year old woman, with reivew of the cytopathologic findings. FNA revealed losely cohesive or sheets of sheets of large oval to polygonal Hurthle cells containing bundant granular cytoplasm. The histopathologic examination confirmed the diagnosis of HCA with follicular growth pattern, Ultrastructurally, the cytoplasm was packed with variable sized mitochondria.
Adenoma* ; Adenoma, Oxyphilic ; Aged ; Biopsy, Fine-Needle* ; Cytoplasm ; Diagnosis ; Female ; Humans ; Mitochondria ; Oxyphil Cells ; Thyroid Gland

BACKGROUND: Oncocytic neoplasms of the salivary glands are rare and the differential diagnosis between oncocytic carcinomas (OCs) and oncocytomas is difficult. We present 5 cases of oncocytoma and 3 cases of OC of the salivary glands with clinicopathological and immunohistochemical comparisons. METHODS: Eight cases of oncocytic neoplasms diagnosed at Asan Medical Center between 1998 and 2009 were reviewed for clinical data and histological features. Immunohistochemical staining for epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (Her-2), c-kit, p53, and Ki-67 was done. RESULTS: Cytological differences between oncocytomas and OCs were not obvious, but unequivocal infiltrative growths were identified in 3 cases, rendering the diagnosis of oncocytic carcinoma. When the remaining cases were classified as oncocytomas, there was no difference in age, size, and clinical symptoms between oncocytomas and OCs. Two of 3 OCs showed strong membranous expression of c-kit, but all oncocytomas were negative. The proportion of p53-positive cells was larger in OCs than oncocytomas. Her-2 or EGFR expression was absent, and Ki-67 labeling indices were less than 1% in all cases. CONCLUSIONS: An infiltrative growth pattern, strong membranous expression of c-kit, and an increased proportion of p53-positive cells are features that can differentiate OCs from oncocytomas of the salivary glands.
Adenocarcinoma ; Adenoma, Oxyphilic ; Diagnosis, Differential ; Humans ; Oxyphil Cells ; Receptor, Epidermal Growth Factor ; Receptor, erbB-2 ; Salivary Glands