1.SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer.
Jung Taek KANG ; Hyung Jin KIM ; Hyun Ju OH ; So Gun HONG ; Jung Eun PARK ; Min Jung KIM ; Min Kyu KIM ; Goo JANG ; Dae Yong KIM ; Byeong Chun LEE
Journal of Veterinary Science 2012;13(2):211-213
Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but developed ovotestis. Through molecular analysis of the SRY gene, a mutation in the coding sequence of SRY gene could be excluded as a cause of intersexuality. This is the first report of a cloned wolf with a 78, XY ovotesticular disorder affecting sexual development characterized by bilateral ovotestes.
Animals
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Cloning, Organism/*veterinary
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Female
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Karyotyping
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Mutation
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Nuclear Transfer Techniques/*veterinary
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Ovotesticular Disorders of Sex Development/pathology/*veterinary
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*Wolves
Result Analysis
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