Background: Over the past 20 years, world wide scale social and economic reforms, technological breakthroughs, and the population growth (increased by 1.64 billion), especially in urban areas, have had a negative impact on human health; changes in living and working conditions (environmental and air pollution), population density, traffic jam, unhealthy lifestyles, workload, and work stress – all contribute to non-communicable diseases – are increasing. According to researchers from Stanford University in the United States, “Stress plays a key role in the development of behavioral disorders such as poor diet, lack of exercise, alcohol and tobacco use, and addiction. Furthermore, these behavioral disorders play a major role in the development of metabolic disorders and cancer, such as hypertension, cardiovascular disease such as myocardial infarction, and diabetes and obesity. “Stress, in particular, depends on the type of workplace, work environment, and occupation in which the person spends most of their life. Materials and Methods: The study is covered 473 nurses from the specialized tertiary level hospitals in Mongolia. We determined their perceived work stress by the WPS (3 parts 57 questions) questionnaire of American scientist Rice. The work stress results were analytically analyzed with the cross-sectional method regarding the nurses’ arterial blood pressure. Results: Totally 473, or 121, 89, 146, and 117 nurses participated from NCTO (1), NCMH (3), NCID (4), and NCC (4). In present study, 34 or 7.2% of 18-24 year olds, 139 or 29.4% of 25-30 year olds, 99 or 20.9% of 31-40 year olds, 169 or 35.7% of 41-50, and 32 or 6.8% over 51 year olds. The study was conducted by collecting an age group similar to the age pyramid of nurses working in the hospital. The participants illustrated low levels of work stress in 7.6%, medium levels in 27.1%, and high levels of work stress in 65.3%, respectively. When we examine whether the level of stress exposure of nurses differs between the groups by high, medium, and low levels of workplace stress, the analysis of one factor variance confirms the statistical real difference (F = 3.071), (p = 0.028). The study results revealed that long lasted accumulated work stress trigger the hypertention. Conclusion The onset of stress in a nurse’s workplace depends on many different social factors, such as age, gender, organizational characteristics, organization, place of work, and years of experiences. In conclusion, we agreed with Spruil Tanya et al., that chroronic stress at work can be the reason for the high blood pressure.