The paper outlines the achievements and challenges in the additive manufacturing (AM) application to veterinary practice. The state-of-the-art in AM application to the veterinary surgery is presented, with the focus of AM for patient-specifi c implants manufacturing. It also provides critical discussion on some of the potential issues design and technology should overcome for wider and more eff ective implementation of additively manufactured parts in veterinary practices. Most of the discussions in present paper are related to the metallic implants, manufactured in this case using so-called powder bed additive manufacturing (PB-AM) in titanium alloy Ti–6AL–4V, and to the corresponding process of their design, manufacturing and implementation in veterinary surgery. Procedures of the implant design and individualization for veterinary surgery are illustrated basing on the four performed surgery cases with dog patients. Results of the replacement surgery in dogs indicate that individualized additively manufactured metallic implants signifi cantly increase chances for successful recovery process, and AM techniques present a viable alternative to amputation in a large number of veterinary cases. The same time overcoming challenges of implant individualization in veterinary practice signifi cantly contributes to the knowledge directly relevant to the modern medical practice. An experience from veterinary cases where organ-preserving surgery with 3D-printed patient-specifi c implants is performed provides a unique opportunity for future development of better human implants.
Alloys ; Amputation ; Animals ; Dogs ; Humans ; Osteosarcoma ; Surgery, Veterinary ; Titanium

Low-grade myofibroblastic sarcoma (LGMS) is a rare, malignant tumor with myofibroblastic differentiation. Despite it being classified as a distinct entity by the World Health Organization, a few cases were reported in the oral and maxillofacial region. Here, a LGMS developed on the palate of a 73-year-old man who presented with a 1-cm tumor on the posterior border of the palate. Based on the histological and immunohistochemical features, a diagnosis of LGMS was established. The tumor was resected, and no recurrence was observed over 2 years. Although the tongue is the most preferred site for LGMS, it may occur in any region of the oral cavity.
Aged ; Humans ; Male ; Myofibroblasts ; pathology ; Osteosarcoma ; pathology ; surgery ; Palatal Neoplasms ; pathology ; surgery ; Palate, Hard ; pathology

Adult ; Cardiopulmonary Bypass ; Female ; Heart Neoplasms ; surgery ; Humans ; Lung Neoplasms ; secondary ; Osteosarcoma ; secondary ; surgery

Bone Neoplasms/surgery* ; Hospitals ; Humans ; Neoplastic Cells, Circulating ; Osteosarcoma/surgery* ; Pilot Projects

Humans ; Male ; Osteosarcoma ; complications ; diagnostic imaging ; surgery ; Ultrasonography ; Wounds and Injuries ; complications ; Young Adult

PURPOSE: We analyzed survival rates and the prognostic factors of pulmonary metastases from osteosarcoma. MATERIALS AND METHODS: Between 1989 and 2001, of 312 patients who were diagnosed and treated for osteosarcoma in our institute, 35 patients with pulmonary metastases were included in the present study. We examined the overall survival rates and analyzed prognostic factors, such as age, gender, chemotherapeutic response, number of the pulmonary lesions, and disease-free interval. RESULTS: Overall 3-year and 5-year survival rates were 62.3% and 39.3%. Patients treated with thoracotomy and chemotherapy seemed to survive longer than patients without thoracic surgery. In the thoracostomy group, the degree of tumor necrosis after neoadjuvant chemotherapy, the number of metastatic nodules, and the tumor free interval were meaningful factors of survival. CONCLUSIONS: In osteosarcoma with pulmonary metastasis, complete metastatectomy and intensive postoperative chemotherapy can improve survival in selected patients.
Drug Therapy ; Humans ; Necrosis ; Neoplasm Metastasis* ; Osteosarcoma* ; Survival Rate ; Thoracic Surgery ; Thoracostomy ; Thoracotomy

Humans ; Solitary Fibrous Tumors/pathology* ; Osteosarcoma/pathology* ; Fibrosarcoma ; Bone Neoplasms/surgery*

OBJECTIVETo evaluate the local recurrence and 5-year survival of proximal fibular osteosarcoma.

METHODSFrom October 1997 to July 2005, 12 patients with proximal fibular osteosarcoma were treated. There were 9 males and 3 females. The mean age at diagnosis was 16 (9-23) years old. Histopathological diagnosis were obtained by trut-cut biopsy, Enneking surgical stages of 12 lesions were as follows: 11 grade II B and 1 grade III. Induction chemotherapy was applied to all patients except one who left the hospital after the biopsy. Of 11 patients, 8 were performed Malawer type I resection, and 3 type II. All patients continued to get postoperative chemotherapy.

RESULTSRegular follow-up was applied. Only 1 patient was found local recurrence one year after operation and received re-resection, the others did not. Four patients died of lung metastases, including the one who did not get treated, one stage III and two II B patients. The range of follow up was 6 to 117 months. The evaluated 5 year disease-free survival of 11 patients who got treated was 72.7% by using Kaplan Meier survival analysis.

CONCLUSIONSThe local recurrence is low, and 5 year disease-free survival is acceptable, in accordance with present point that marginal resection may not impact survival for fibular osteosarcoma. No knee instability is found in this group after great care is taken for proper reconstruction of lateral collateral ligament and reinsertion of biceps femoris tendon on the lateral condyle of tibia.

Adolescent ; Adult ; Bone Neoplasms ; surgery ; Child ; Female ; Fibula ; Follow-Up Studies ; Humans ; Male ; Neoplasm Recurrence, Local ; Osteosarcoma ; surgery ; Survival Analysis

Multilobular tumor of bone detected in a 2.5-year-old male Pekingese dog is reported. Grossly, the neoplasm consisted of multiple, variably sized, gritty, grayish-white to yellow nodules separated by thick collagenous septa. Histologically, these nodules contained multiple lobules of irregularly shaped and sized islands of well-differentiated osteoid and cartilage, separated by anastomosing fibrovascular septa. Chondrocytes and osteocytes were observed in the lacunae and in more osseous islands in the lobule, respectively. These lobules were surrounded by mesenchymal spindle cells. Mitotic figures were not evident. The neoplastic pattern was consistent with that of a multilobular bone tumor. Diagnosis was based on gross and light microscopic findings. The cause of this neoplasm was not determined.
Animals ; Bone Neoplasms/pathology/surgery/*veterinary ; Dog Diseases/*pathology/surgery ; Dogs ; Histocytochemistry/veterinary ; Male ; Mandible/*pathology/surgery ; Osteosarcoma/pathology/surgery/*veterinary

INTRODUCTIONLimb salvage in children with primary malignant bone tumours around the knee is challenging, with considerations such as shortening, bone and joint remodeling and high functional demands of active children. The ultimate aim for reconstruction is restoring a stable, painless and mobile joint. With improved survival rates from chemotherapy, reconstructive techniques should ideally last the child's lifespan. We adopted a biological approach by preserving the patients' native joint, with bony defects bridged by fibula grafts supplemented by autoclaved bone grafts infused with bone marrow. We conducted this retrospective review to determine if we were able to meet our objectives of reconstruction.

MATERIALS AND METHODSA retrospective review of children with osteogenic sarcoma involving the distal femur or proximal tibia treated at our institution was done. Patients aged 13 years and below at the time of surgery who had undergone a limb salvage procedure that preserved the knee joint were included.

RESULTSNine patients were identified, 3 males and 6 females. The average age was 10.0 years (range, 7 to 13 years) at the time of surgery. Seven had tumours involving the distal femur while 2 had tumours involving the proximal tibia. There were no cases of local recurrence. Four of the 9 patients died from metastatic disease, the 5 surviving patients have no evidence of disease, and the average follow-up for survivors was 13.2 years. The average active range of motion for the knee joint was 96° (range, 50° to 130°). The average Musculoskeletal Tumour Society (MSTS) score was 26.3 (range, 23 to 30).

CONCLUSIONWe have observed this technique of limb salvage offers satisfactory limb function with long-term follow-up.

Adolescent ; Bone Neoplasms ; surgery ; Child ; Female ; Femoral Neoplasms ; surgery ; Humans ; Knee Joint ; surgery ; Limb Salvage ; methods ; Male ; Osteosarcoma ; surgery ; Recovery of Function ; Retrospective Studies ; Tibia ; Time Factors ; Treatment Outcome