1.Severe Osteomyelitis as a Complication of Tokyo-172 BCG Vaccination.
Hyo Jin KWON ; Bo Hyun CHUNG ; Byung Min CHOI ; Kyung Un PARK ; Yun Kyung KIM
Journal of Korean Medical Science 2012;27(2):221-224
The bacilli Calmette-Guerin (BCG) Tokyo-172 strain was considered to exhibit good protective efficacy with a low rate of unfavorable side effects. However, we describe a rare case of BCG osteomyelitis developed in an immunocompetent host who was given with BCG Tokyo-172 vaccine on the left upper arm by multipuncture method. A 9-month-old girl presented with progressive inability to move her right elbow and had radiographic evidence of septic elbow combined with osteomyelitis of right distal humerus. A biopsy from the site revealed chronic caseating granulomatous inflammation, positive for BCG Tokyo-172 strain on the multiplex polymerase chain reaction. The child had to undergo second surgical debridements and oral antituberculosis chemotherapy. There were no sequelae after 2 yr of follow-up. This complication, although uncommon, should be considered in the appropriate clinical setting.
Antitubercular Agents/therapeutic use
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BCG Vaccine/*adverse effects
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DNA, Bacterial/genetics
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Female
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Humans
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Infant
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Magnetic Resonance Imaging
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Multiplex Polymerase Chain Reaction
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Mycobacterium bovis/genetics/*isolation & purification
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Osteomyelitis/drug therapy/*etiology/*microbiology/surgery