No abstract available.
Osteomalacia

No abstract available.
Osteomalacia*

We present a case of a 53-year-old woman who developed multifocal insufficiency fractures associated with adefovir dipivoxil (ADV) induced osteomalacia, including recurring metatarsal insufficiency fractures and a subtrochanteric femoral insufficiency fracture requiring surgical fixation. She had received low-dose ADV treatment for 59 months for chronic hepatitis B viral infection at the time of presentation with subtrochanteric fracture. Imaging evidence of multifocal insufficiency fractures and metabolic disease on background of hypophosphatemia is attributed to hypophosphatemic osteomalacia from adefovir-induced renal proximal tubular dysfunction. Radiologists and clinicians should be aware of the possibility of insufficiency fractures in patients receiving ADV therapy to avoid delayed diagnosis and progression of high-risk proximal femoral fractures.
Osteomalacia

Osteomalacia is one of the post-gastrectomy complications resulting from the impaired absorption of vitamin D and calcium.1 Vitamin D deficiency or osteomalacia can be diagnosed by clinical, biochemical and radiographic parameters, and bone biopsy. The radiologic findings of “Looser zones” or pseudofractures aid in the diagnosis. Severe generalized pain, mimicking rheumatologic disorders is one of the features that maybe a presenting complaint of osteomalacia. We report a case of osteomalacia as a consequence of gastric by-pass surgery.
Osteomalacia ;

No abstract available.
Adult* ; Humans ; Osteomalacia*

No abstract available.
Fractures, Bone ; Osteomalacia

PURPOSE: Chronic use of anticonvulsant bring about abnormalities of bone metabolism, as hypocalcemia, rickets and osteomalacia. Early detection and treatment of abnormalities is important to pediatric patients. To investigate the usefulness of the serum Ca and 1,25(OH)2D3 as an predictor of bone metabolism abnormality, the study was done. METHODS: Serum Ca, P, ALP and 1,25(OH)2D3 were measured and analyzed in 48 children who diagnosed as convulsive disorder and took anticonvulsant medication over 6 months in Pediatric Department of Kyung Hee Medical Center. RESULTS: 1) Average duration of medication was 3.4+/-2.5yrs. 2) Values of serum Ca and P, ALP, 1,25(OH)2D3 were normal. 3) Serum levels of anticonvulsants were therapeutic range. 4) 1,25(OH)2D3 had significant correlation to serum Ca (P<0.005) and P (P<0.05) but no correlation to ALP. 5) Duration of medication had significant correlation to 1,25(OH)2D3 (P<0.05) but no correlation to Ca. 6) Duration of medication had no correlation to 1,25(OH)2D3 and Ca. CONCLUSIONS: Because 1,25(OH)2D3 is a good predictor for change of bone metabolism by chronic medication of anticonvulsant than Ca, its regular check is necessary.
Anticonvulsants ; Child ; Humans ; Hypocalcemia ; Metabolism* ; Osteomalacia ; Rickets

No abstract available.
Osteomalacia* ; Primary Myelofibrosis* ; Vitamin D Deficiency*

An unusual and rare presentation of osteomalacia results from the paracrine effect of a localized bone or soft tissue neoplasm. In this syndrome, known as tumor induced osteomalacia or oncogenic osteomalacia, a neoplasm synthesizes and secretes a circulating compound, known as phosphatonin, which acts on the kidney leading to phosphate wasting. Oncogenic osteomalacia can be caused by a wide variety of neoplasm, although they are usually primary soft tissue or bone tumors. Most commonly the causative neoplasm is a benign or low-grade malignant vascular or fibrous tissue tumor. Complete removal of the offending neoplasm completely reverses the osteomalacia. If successful, the osteomalacia resolves. However, incomplete removal of the neoplasm necessitates treatment with phosphate and Vitamin D3 to ameliorate the skeletal disease.
Cholecalciferol ; Kidney ; Osteomalacia* ; Soft Tissue Neoplasms

No abstract available.
Giant Cells ; Gingiva ; Granuloma, Giant Cell ; Osteomalacia