Osteochondroma is the most common of the benign bone tumors. They are probably developmental malformations rather than true neoplasms. But rarely they develope in a joint, especially in the ankle joint. We reported a case of intraarticular osteochondromatosis of ankle joint.
Ankle Joint ; Ankle ; Joints ; Osteochondroma ; Osteochondromatosis

PURPOSE: The purpose of this study is to help predict the prognosis of multiple osteochondromatosis patients with the investigation of social function, pain, physical function and quality of life of patients. MATERIALS AND METHODS: Forty-five cases were diagnosed as multiple osteochondromatosis from March 1993 to June 2014. We performed a survey on pain, daily life, school or work life assessment of research and development-36. Forty-five people who responded to the survey completely were enrolled. Variable factors, including physical functioning, role limitations due to physical health, role limitations due to emotional problems, energy/fatigue, emotional well-being, social functioning, pain, and general health state were considered as elements related to quality of life. In addition, we investigated significant factors for multiple osteochondromatosis patients, and analyzed the survey by scoring. Related factors included age (over 18 years and under 18 years), gender, body mass index, operation, joint deformity, recurrence of disease, family history, the number of involved joints and the location of tumor. Statistical analyses were performed using SAS ver. 9.3 (SAS Inc., Cary, NC, USA). p-values of <0.05 were deemed statistically significant. RESULTS: Patients with a family history of multiple osteochondromatosis showed a significantly decreased result of assessment, physical function, vitality of life, social activities, and health state. In addition, there was a tendency of a poor influence in pain, emotional wellbeing, and general health. CONCLUSION: The results suggest that family history is a significant factor influencing and predicting the quality of life. In other words, the developed patients in the household including patients with severe enough for the rest of the family to know have poor prognosis. Through this study multiple osteochondromatosis is a chronic disease having a profound impact on quality of life.
Body Mass Index ; Chronic Disease ; Congenital Abnormalities ; Exostoses, Multiple Hereditary ; Family Characteristics ; Family Relations ; Humans ; Joints ; Osteochondromatosis* ; Prognosis ; Quality of Life* ; Recurrence

Primary synovial osteochondromatosis is a disorder characterized by the formation of multiple intra-articular osteocartilaginous bodies. Clinical symptoms are not specific, which makes the diagnosis difficult. Magnetic resonance imaging is useful in the diagnosis of synovial osteochondromatosis of the hip, especially in cases in which ossified bodies are not present. Synovial osteochondromatosis tends to be progressive but self-limiting and the optional treatment is controversial. We described two patients with primary osteochondromatosis of hip who presented with symptoms and signs of single joint arthropathy of hip.
Chondromatosis, Synovial* ; Diagnosis ; Hip ; Humans ; Joints ; Magnetic Resonance Imaging ; Osteochondromatosis

A chondrosarcoma of thoracic spine with local recurrence is described in a 40.year.old man having osteochondromatosis. We had performed a subtotal resection of a chondrosarcoma 3.5 years ago. However, the tumor had grown larger than the initial size. The patient showed symptoms of myelopathy. He was treated with a staged posterior spinal fusion and anterior decompression/corpectomy for grossly total removal of the chondrosarcoma. The patient had near.complete resolution of his myelopathy after surgery, immediatly. Follow.up at 6 months revealed no recurrence and the patient had recovered normal muscle power. Even low grade chondrosarcomas have a high recurrence rate and respond poorly to medical treatments such as chemotherapy or radiotherapy, making total surgical resection is the most important treatment. For good therapeutic results, the chondrosarcoma should be performed aggressive total resection.
Chondrosarcoma ; Humans ; Muscles ; Osteochondromatosis ; Recurrence ; Spinal Cord Diseases ; Spinal Fusion ; Spine

PURPOSE: To assess the MR findings of symptomatic osteochondromas. MATERIALS AND METHODS: We evaluated 31patients who between July, 1994 and May, 1997 underwent MR imaging for symptomatic osteochondroma. Fourteen were males and 17 were females, and their ages ranged from 8 to 49(mean, 23) years. Using T1WI, T2WI andgadolinium-DTPA-enhanced T1WI, images were analysed according to signal intensity in the osseous component of theosteochondroma, thickness of the cartilage cap, and associated change in surrounding soft tissue. RESULTS:Clinical manifestations included a palpable mass or tendency to grow(n=22) and pain on movement(n=9).Complications were of three types : that which followed change in the osseous component of the tumor, associatedchange in surrounding soft tissue, and malignant transformation. In the osseous component, bone marrow edema orcontussion was seen in 21 cases(67.7%), and in two(65%), fracture was observed. In surrounding soft tissue, muscleimpingement was seen in 21 cases(67.7%), bursitis was in 7 cases(22.6%), tenosynovitis in seven(22.6%), andvascular compression in five(16.1%). In three cases(9.7%), thansformation to chondrosarcoma had occurred ; two ofthese were derived from osteochondromatosis and one from a single osteochondroma. The thickness of the cartilagecap was as follows : <5mm(n=16), 5-10mm(n=12), and > 10mm(n=3). CONCLUSION: In patients with symptometicosteochondroma, MR imaging is useful for detecting both complications and malignant transformation.
Bone Marrow ; Bursitis ; Cartilage ; Chondrosarcoma ; Edema ; Female ; Humans ; Magnetic Resonance Imaging* ; Male ; Osteochondroma* ; Osteochondromatosis ; Tenosynovitis

PURPOSE: To analyze clinical, radiological and pathological features as well as clinical outcome after surgical treatment of patients with secondary chondrosarcoma arising from osteochondroma(tosis). MATERIALS AND METHODS: We retrospectively reviewed clinical records, radiographs, pathologic slides of 14 patients. Nine patients were male and five were female. The mean age was 34 years. The mean follow-up period was 54 months. RESULTS: All patients had a history of previous mass since childhood or puberty. Preexisted osteochondroma was single in 3 patients and multiple in 10. Remaining 1 patient had multiple osteochondromatosis with enchondromatosis. MRI clearly provided thickness of cartilage cap, which was over 2 cm except in 2 cases. Chondrosarcoma was grade 1 in all except 1 case, which was grade 2. Wide excision was performed in 10 patients, marginal excision in 3 and amputation in 1. Twelve patients were doing very well without evidence of disease. Among 3 patients with marginal excision, 1 patient had local recurrence and 1 patient died of disease. CONCLUSION: Comprehensive understanding of clinical, radiological and pathological features of secondary chondrosarcoma is warranted for accurate diagnosis. The best result can be expected with early recognition of malignant change of osteohcondroma(tosis) and wide excision.
Amputation ; Cartilage ; Chondrosarcoma ; Enchondromatosis ; Female ; Follow-Up Studies ; Humans ; Male ; Osteochondroma ; Osteochondromatosis ; Puberty ; Recurrence ; Retrospective Studies

PURPOSE: To evaluate the relationships between mutations of the p53 and MDM-2 proteins in human primary chondrosarcoma and in secondary chondrosarcoma from osteochondromatosis. MATERIALS AND METHODS: From January, 1984 to April, 2000, 33 cases were grouped into three categories: Group I, osteochondromatosis (18 cases), group II, secondary chondrosarcoma (6 cases), group III, primary chondrosarcoma (9 cases). We analysed the expressions of the p53 and MDM-2 proteins. All specimens were embedded in paraffin and stained using the Streptavidin-Biotin peroxidase method with anti-p53 antibody, and DO7 anti-MDM-2 antibody IF2 as monoclonal antibody. RESULTS: The expressions of the p53 and MDM-2 proteins, the pathologic grade of each group, and clinical outcomes were compared and analysed. The expressions of the p53 and MDM-2 proteins in each group were significantly different (p<0.05). However, MDM-2 protein expression was similar between group II and III. Both p53 and MDM-2 protein were expressed most frequently in group III and this was significant. There was an increased manifestation of the p53 and MDM-2 protein in the higher pathologic grade. The 5-year survival rate of patients with a malignant tumor was about 70%. In expired patients, the histologic grade was grade III, and both proteins were expressed, which enabled a relationship to be established between p53 and MDM-2 protein expression and a poorer prognosis. CONCLUSION: In osteochondromatosis, the coexpression of the p53 and MDM-2 proteins was not observed, but isolated p53 or MDM-2 expression was observed in some cases. According to this study, it is helpful as a basic study for early detection of malignant translation of osteochondromatosis. In conclusion, we suggest that the expressions of the p53 and MDM-2 proteins are useful indicators of prognosis.
Chondrosarcoma* ; Humans ; Osteochondromatosis* ; Paraffin ; Peroxidase ; Prognosis ; Proto-Oncogene Proteins c-mdm2 ; Survival Rate

PURPOSE: We analyzed the oncological outcome and prognostic factor of the chondrosarcoma arising from benign bone tumor due to malignant transformation. MATERIALS AND METHODS: From April 1986 to April 2009, 18 cases were considered eligible. We analyzed retrospectively the patient's characteristics and prognostic factors that affect to the local recurrence and distant metastasis. RESULTS: As classified by primary benign bone tumor, 4 cases were solitary osteochondroma, 11 cases were multiple osteochondromatosis and 3 cases were multiple enchondromatosis. The mean follow-up period was 85 months. The 5-year disease free survival rate of 18 patients was 85.9%. Their overall MSTS score was 25.2 (84%). There were local recurrence in 3 cases and no distant metastasis. We found that tumor location and surgical margin affected to the prognosis significantly. CONCLUSION: In secondary chondrosarcoma patients, the prognosis was good relatively and tumor location and surgical margin are important prognosis factor.
Chondrosarcoma ; Disease-Free Survival ; Enchondromatosis ; Follow-Up Studies ; Humans ; Neoplasm Metastasis ; Osteochondroma ; Osteochondromatosis ; Prognosis ; Recurrence ; Retrospective Studies

Synovial chondromatosis is an uncommon disorder characterized by cartilaginous proliferation within the synovial membrane of the articular joint. Smaller joints are rarely affected and it may be progressed to osteochondromatosis after ossification or calcification of metaplastic cartilage. It is commonly presented in the third to fourth decade of life, but rarely presented in adolescence. We report a unique case of synovial osteochondromatosis of the subtalar joint in 14-year-old baseball player. Arthroscopic removal of loose body and complete excision of the osteochondral mass with concomitant synovectomy resulted in satisfactory outcome without recurrence at final follow-up.
Adolescent* ; Arthroscopy ; Baseball* ; Cartilage ; Chondromatosis, Synovial* ; Follow-Up Studies ; Humans ; Joints ; Osteochondromatosis ; Recurrence ; Subtalar Joint* ; Synovial Membrane

Osteochondroma is the most common of primary benign bone tumors. It is characterized by protruding mass from metaphysic of long bone with semitranslucent cartilaginous cap on its surface. This lesion, which has its own growth plate, usually stops growing at skeletal maturity. The multiple variant of osteochondroma, namely the osteochondromatosis, may show various deformities around the joints in its course. In addition, sarcomatous change is sometimes developed. One hundred and twenty one patients were diagnosed as osteochondroma or osteochondromatosis from Jan. 1981 to Dec. 1991, and followed-up for 3.4 years(6months-8years). There were 74 cases of solitary osteochondroma(male : female=1.47 : 1), and 47 cases of osteochondromatosis (male : female=1.61:1). The age at initial visit was averaged 19.5 years(2 years 8 months-58 years). In our experience, common sites were distal femur, proximal tibia, proximal humerus in solitary osteochondroma, proximal tibia, distal femur, distal tibia in osteochondromatosis. Mass with or without pain was the most common chief complaint. Familial histories were noted in 38% of osteochondromatosis. The deformity, which needed correction, were found in 10 among 119 cases ; corrective osteotomy in 7 cases, lengthening with Ilizarov apparatus in 3 cases. The complications such as limitation of motion, sensory disturbance, recurrence, persistent deformity after corrective surgery, epiphyseal plate injury, superficial infection, were noted in 28%. During the follow-up period, there were one case of malignant transformation, and recurrence was identified in 7 cases and three of them were reoperated. Interestingly, progressive deformity was noted in 3 cases postoperatively. And, if the tumor produces no symptom and no functional impairment, we recommend minimizing the indication of surgical intervention. In particular, special attention must be taken in growing children in order to avoid inadvertent complications such as progressive deformity.
Child ; Congenital Abnormalities ; Femur ; Follow-Up Studies ; Growth Plate ; Humans ; Humerus ; Joints ; Metaphysics ; Osteochondroma ; Osteochondromatosis ; Osteotomy ; Recurrence ; Tibia