No abstract available.
Acromegaly* ; Osteoarthropathy, Primary Hypertrophic*

No abstract available.
Osteoarthropathy, Primary Hypertrophic*

No abstract available.
Osteoarthropathy, Primary Hypertrophic*

A rare case of idiopathic Hypertrophic Osteoarthropathy is reported, who exhibited all typical clinical features, such as grimmy face with deep furrows, cylindrical enlargement of long bones, clubbing of digits and joint trouble. No underlying cause was detectable, Radiological and pathological investigations are presented and review of references as well.
Joints ; Osteoarthropathy, Primary Hypertrophic

This is a rare case of primary pachydermoperiostosis (PDP). A 28-year-old Filipino male presented with a lifelong history of enlarged hands and feet. He eventually developed symmetrical swelling of the ankles and knees associated with leg heaviness and knee pain with difficulty with ambulation, hence consult. His eldest brother also had the same “elephant-like” extremities. He had cutis vertices gyrata with a thickened corrugated hair pattern, deep lines on the forehead, deepened nasolabial folds, enlarged extremities especially distally, with coarse, thick skin, and prominent clubbing. The nails were convex “watch crystal-like.” The wrists, knees, and ankles were tender and enlarged, with massive effusion of the knees. All joints were devoid of warmth and erythema. Skeletal survey favored hypertrophic osteoarthropathy over acromegaly, with periosteal thickening of the metaphysis and digital clubbing. The filarial smear was negative for blood parasites. Skin biopsy showed keratoderma. Synovial fluid was non-inflammatory while arthroscopic synovial biopsy showed chronic inflammation eosinophilic amorphous tissue. Electrocardiogram, echocardiogram, thyroid function tests, complete blood count, peripheral blood smear, serum chemistries, coagulation tests, urinalysis, urine electrolytes, fecalysis, and chest CT scan were unremarkable. Whole abdomen ultrasound revealed the liver parenchymal disease. Hepatitis profile revealed chronic infection with hepatitis B, with low infectivity. The three major criteria for PDP (pachydermia, periostitis, and digital clubbing) were fulfilled. Possible secondary causes were either excluded or were non-contributory. He was started on analgesics and anti-inflammatory medicines. Repeated arthrocenteses drained liters of synovial fluid per knee, and along with intra-articular steroid injections and compressive bandages, temporarily relieved his bilateral knee pain. He was referred to rehabilitation to maximize his range of motion and to address body image issues. The patient remains on regular follow-up for periodic arthrocentesis. The option of anti-VEGF treatment and arthrotomy was explored as possibilities but were not deemed practical. PDP is a rare genodermatosis. Life span is not affected but the quality of life is dismal without supportive management, as there is no known cure. A multidisciplinary team composed of a rheumatologist, dermatologist, orthopedic surgeon, plastic surgeon, rehabilitation physician, and a psychiatrist should be available to assist in the needs of these patients.
Osteoarthropathy, Primary Hypertrophic

Touraine-Soulente-Gole Syndrome (TSG) or pachydermoperiostosis is a rare disorder characterized by pachydermia, periostosis & digital clubbing. Herein, we report a case of a 27 year old male, with the looks of a 47 year old. He presented with excessive wrinkling on his face since past 8 years. TSG syndrome was suspected and examined by histopathological, endocrinological and radiological studies for the confirmation of clinical diagnosis.
Humans ; Male ; Osteoarthropathy, Primary Hypertrophic

Touraine-Soulente-Gole Syndrome (TSG) or pachydermoperiostosis is a rare disorder characterized by pachydermia, periostosis & digital clubbing. Herein, we report a case of a 27 year old male, with the looks of a 47 year old. He presented with excessive wrinkling on his face since past 8 years. TSG syndrome was suspected and examined by histopathological, endocrinological and radiological studies for the confirmation of clinical diagnosis.
Humans ; Male ; Osteoarthropathy, Primary Hypertrophic

A study was conducted from July to Sept 2002 on old women (>59 years old) at Nguyen Xa, Tan Hoa and Song Lang communes in Vu Thu district, Thai Binh province. Results showed that the incidence of osteoarthropathies was the highest morbidity (71.9%) in comparing with other diseases. Among them, 55.1% had pain at spinal column, 38.8% had pain at joints of the limbs, with a highest incidence in 80-89 age group. The osteoarthropathic patient group joined in exercises was lower than control group, but the joining physical activities as well as the intake of meat, fish, bean,… were similar to control group
Osteoarthropathy, Primary Hypertrophic ; Aged ; Women

No abstract available.
Osteoarthropathy, Primary Hypertrophic* ; Peptic Ulcer* ; Polyps* ; Stomach*

OBJECTIVETo investigate the treatment and possible pathogenesis of pachydermoperiostosis.

METHODSFacelift was performed on five patients with pachydermoperiostosis. Histological studies were performed to check the affected skin for possible pathogenesis.

RESULTSAfter the surgery of facelift, appearances of the patients were markedly improved. Histological studies revealed significant changes in the skin, characterized by hyperplasia and thickening of the subcutaneous collagen, as well as an increase of PAS-positive substance.

CONCLUSIONAlterations of fibroblast bioactivity might be responsible for the pathogenesis of pachydermoperiostosis. There have been no satisfying treatments to the disease. Facelift is a feasible method to improve the aging appearance of the patients.