1.Evaluation of the effects of bupivacaine combined with sugammadex on the duration of the nociceptive blockade in sciatic nerve blocks: a controlled, double-blind animal study
Omer TASARGOL ; Isfendiyar DARBAZ ; Osman ERGENE ; Feride ZABITLER ; Aziz DENIZ ; Selin Guven KOSE ; Halil Cihan KOSE ; Serkan TULGAR
Korean Journal of Anesthesiology 2023;76(2):152-159
Background:
Animal and other experimental studies have demonstrated increased block time and quality when α- and β-cyclodextrin drugs are combined with local anesthetics. However, to our knowledge, no study has utilized γ-cyclodextrins in such a combination. In the present study, we used an animal model to evaluate the effects of different doses of the combined administration of γ-cyclodextrin (sugammadex) and bupivacaine on the duration of sciatic nerve blocks in rats.
Methods:
Sciatic nerve blocks were performed with a 0.20 ml mixture in all groups. For the non-experimental groups, this mixture consisted of 0.2 ml saline (Sham group), 0.2 ml sugammadex (Group S), or 0.16 ml bupivacaine 0.5% and 0.04 ml saline (Group B). For the experimental groups, 0.16 ml bupivacaine 0.5% was administered along with 0.01 ml sugammadex and 0.03 ml saline (Group BS1), 0.02 ml sugammadex and 0.02 ml saline (Group BS2), or 0.04 ml sugammadex (Group BS4). Proprioception, nociception, and motor function were evaluated until the sciatic block was completely reversed.
Results:
Motor, proprioceptive, and nociceptive blockades occurred within 5 min in all experimental groups. In Group BS4, the duration of the motor, proprioceptive, and nociceptive blockades was significantly increased compared with the other experimental groups. However, in Groups BS1 and BS2, only the duration of the nociceptive blockade was significantly increased.
Conclusions
The combined administration of sugammadex and bupivacaine for sciatic nerve blocks in rats led to a significant increase in the duration of motor, proprioceptive, and nociceptive blockades.
2.Acute Generalized Exanthematous Pustulosis Due to Oral Use of Blue Dyes.
Osman SENER ; Osman KOSE ; Ozgur KARTAL ; Mukerrem SAFALI
The Korean Journal of Internal Medicine 2011;26(3):360-363
Acute generalized exanthematous pustulosis is a rare severe pustular cutaneous adverse reaction characterized by a rapid clinical course with typical histological findings. It is accompanied by fever and acute eruption of non-follicular pustules overlying erythrodermic skin. The causative agents are most frequently antibacterial drugs. We present a patient with acute generalized exanthematous pustulosis caused by methylene blue and indigotin dyes.
Acute Generalized Exanthematous Pustulosis/*chemically induced/drug therapy/pathology
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Administration, Oral
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Adrenal Cortex Hormones/therapeutic use
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Aged
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Biopsy
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Coloring Agents/administration & dosage/*adverse effects
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Humans
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Indoles/administration & dosage/*adverse effects
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Intradermal Tests
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Male
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Methylene Blue/administration & dosage/*adverse effects
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Skin/*drug effects/pathology
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Treatment Outcome