Based on the results of 20 cases with mumps orchitis who were treated with Prednisolon (25-30 mgs per day in 5 days) or Triamcinolon (5-6 mgs per day in 5 days), the author showed that corticoids could either release fever and pain within 24 hours or 48 hours, or reduce the swelling of orches faster in comparison with the other group of patients. Nevertheless, corticoids could not prevent the orches shrinking
Orchitis ; Mumps ; Therapeutics ; Adrenal Cortex Hormones

Cryptococcus is native to the environment and thrives in any type of environment inhabited by birds. Cryptococcal genito-urinary infection has been reported in immunnocompromised patients and can involve the adrenal gland, kidney, prostate, or penis. To our knowledge, there have been no reports of cases where cryptococcal epididymo-orchitis infects an uncompromised healthy host. Here, we report a case of primary cryptococcal epididymo-orchitis in a healthy male.
Adrenal Glands ; Birds ; Cryptococcus ; Humans ; Kidney ; Male ; Orchitis ; Penis ; Prostate

Cysts ; Epididymitis ; Humans ; Male ; Orchitis ; Urinary Tract Infections

PURPOSE: Mumps orchitis rarely occurs in prepubescent boys, but it is common in adolescents and adults. Approximately 30-40% of the affected testes are said to atrophy within several months as a complication, but any study on this is lacking. We studied the clinical outcomes and the ultrasonographic findings of mumps orchitis. MATERIALS AND METHODS: We studied 15 patients who had been hospitalized and followed up for more than 3 months from July 2003 to June 2005. The average age of the patients was 16 years old. The patients' medical history, therapeutic measures and clinical outcomes were recorded, and scrotal color doppler ultrasonography was performed at the follow up sessions after the treatment. The criteria for testicular atrophy have been set according to the contralateral testicular volume reduction of 20% or 2ml. RESULTS: During an average of 10 months of follow up period, 9 of 15 patients experienced atrophy and the contraction rate of the affected testes was about 39.8%. Two of 5 patients who under systemic interferon-alpha2b treatments experienced atrophy and their contraction rate was about 46.5%. On the ultrasonography, inhomogeneous and decreased echogenicity was noted in the atrophic testes and the blood flow comparably decreased. CONCLUSIONS: From the study, it has been confirmed that the interfereon-alpha2b treatment was not adequate to completely prevent the atrophy. Scrotal ultrasonography is a useful examination that is able to measure the correct testicular volume and judge testicular atrophy. As mumps orchitis seem to induce testicular atrophy, periodic check up may be required after the acute stage.
Adolescent ; Adult ; Atrophy ; Follow-Up Studies ; Humans ; Male ; Mumps* ; Orchitis* ; Testis ; Ultrasonography ; Ultrasonography, Doppler, Color

The review summarized the recent progress on macrophages of male reproductive tract and the action of macrophages on male reproductive physiology and pathology. The close correlation and effect between testicular macrophages and Leydig cells, Sertoli cells, germ cells, hypothalamic-pituitary-gonadal axis were introduced, respectively. At the same time, it pointed out the changes of macrophages' morphology and function in immune orchitis, and their regulation on the development of orchitis. So the complex immune regulation network in testes and testicular macrophages playing an important role on spermatogenesis and the stableness of spermatogenetic microenvironment in testes were further illuminated, which can provide theoretical basis for clinic therapy.
Genitalia, Male ; cytology ; immunology ; physiology ; Humans ; Macrophages ; cytology ; immunology ; Male ; Orchitis ; immunology ; pathology ; Spermatogenesis ; physiology

OBJECTIVETo investigate the epidemiological characteristics, clinical manifestations, diagnosis, and treatment of Brucella orchitis, so as to provide reliable evidence for the prevention and treatment of the disease.

METHODSWe conducted retrospective statistical analyses on the medical records of 48 outpatients and 21 inpatients with Brucella orchitis.

RESULTSBrucella orchitis was diagnosed in 6.67% of the male patients with brucellosis (69/1 034). The disease exhibited typical epidemiological features, with a higher incidence rate among those in frequent contact with sheep and elderly people, in the period from April to July, and in the areas with sheep husbandry. All the Brucella orchitis patients had such local symptoms as testicular pain and swelling, more frequently involving both testes, and other most common symptoms included fever, chills, sweating, and painful joints. Based on IIEF-5, 45 of the patients suffered from severe erectile dysfunction, with their reproductive function temporarily affected in the course of the disease. Misdiagnosis easily occurred in the early stage of the disease. Therapeutic options mainly included doxycycline hydrochloride and rifampicin, administered orally or intravenously, which could effect a cure, though relapse might occur in some cases.

CONCLUSIONBru- cella orchitis has distinct epidemiological characteristics, with clinical manifestations of testicular pain and swelling. Though a transient disease, it affects the reproductive function of the patient before cured. It can be treated by combined oral and intravenous medication, with painkillers or ice bags for testicular pain and swelling.

Animals ; Brucella ; pathogenicity ; Brucellosis ; complications ; diagnosis ; therapy ; Humans ; Male ; Orchitis ; diagnosis ; microbiology ; therapy ; Retrospective Studies ; Sheep

Acute eididymo-orchitis is the most common cause of intrascrotal inflammation, and retrograde ascent of pathogens is the usual route of infection. Here we intend to present a case of young boy, not sexually active, suffering from acute epididymo-orchitis due to Pseudomonas aeruginosa presented with acute respiratory distress syndrome. Proper timely diagnosis of the primary cause and prompt treatment including support with non invasive ventilation lead to a favourable outcome in the same case.
Adolescent ; Dyspnea ; Epididymitis ; Humans ; Male ; Orchitis ; Pseudomonas Infections ; Pseudomonas aeruginosa ; Respiratory Distress Syndrome, Adult

Brucellosis is a zoonosis, which is caused by Brucella abortus, B. melitensis, B. suis and B. canis. Brucellosis has been an emerging disease since the discovery of B. melitensis, by Bruce, in 1887. Worldwide, brucellosis remains a major source of disease in both humans and domesticated animals. A high prevalence in certain geographical areas is well recognized, but has been largely underestimated. In Korea, the first human case of Brucellosis occurred in 2002, but the incidence of human brucellosis has now increased. Herein, a case of epididymorchitis due to brucellosis is reported.
Animals, Domestic ; Brucella abortus ; Brucella* ; Brucellosis ; Epididymitis ; Humans ; Incidence ; Korea ; Male ; Orchitis ; Prevalence

Mumps orchitis represents the most common complication of mumps infections and occurs in 5 to 37% of the populations. The most important danger is the risk of testicular atrophy up to 50% of affected testis which results in sterility. Two patients with mumps orchitis received systemic treatment with Interferon-alpha2(INF-alpha2)(3x06IU per day) for 7 days. All acute symptoms and signs of mumps orchitis disappeared within 4-7 days of INF-alpha2 therapy. No incidence of testicular atrophy was observed at the 19 and 6 months follow-up, respectively. No significant adverse effects of drug were occurred during treatment. We recommend the immediate interferon therapy, as soon as mumps orchitis manifests, to relieve clinical manifestation and to prevent testicualr atrophy and resulting infertility.
Atrophy ; Follow-Up Studies ; Humans ; Incidence ; Infertility ; Interferons ; Male ; Mumps* ; Orchitis* ; Testis

Postpubertal mumps may result in ochitis and permanent testicular atrophy may develop following infection. This present study was initiated to evaluate the preventive effect of interferon-alpha2B on infertilty after mumps orchitis. There were 21 patients with mumps orchitis between May 1990 and June 1997. Patients were randomly distributed into 2 groups: group 1 patients (n=13) maintained therapy with interferon-alpha2B (3x10(6) IU per day) and group 2 were managed by conservatively. All of the patients were evaluated with testis size measurement, mumps virus titer, hormone level, and if possible semen analysis. For group 1 patients symptoms disappeared within 2 to 3 days and the volume of testis returned to normal within 11 days and testis atrophy was not observed in all patients in follow up. But asthenospermia was continued in 4 patients (unilateral 2, bilateral 2). For group 2 patients symptoms disappeared within 5 to 6 days and the volume of testis returned to normal within 10 days and testis atrophy was observed in 3 patients (unilateral 2, bilateral 1) in floow up. Asthenospermia was continued in 4 patients (unilateral 2, bilateral 2). Sperm count and morphology were recovered all the recover in group 1, 4 patients had persistent reduced sperm count and morphology in group 2, respectively. These observations suggest that systemic interferon-alpha2B treatment is highly effective in preventing infertility as well as testicular atrophy after mumps orchitis.
Atrophy ; Follow-Up Studies ; Humans ; Infertility* ; Male ; Mumps virus ; Mumps* ; Orchitis* ; Semen Analysis ; Sperm Count ; Testis