No abstract available.
CD4 Lymphocyte Count* ; Humans ; Oral Manifestations*

Non-Hodgkin's lymphoma is a heterogenous group of neoplasm affecting the lymphoid system. About 10% of Non-Hodgkin's lymphoma occur in the extra-nodal region in the head and neck area and more than half of extra-nodal lymphoma in the head and neck area involves the Waldeyer's ring. Localization in the oral cavity is rare. We experienced one rare case of Non-Hodgkin's lymphoma in the oral cavity, with trismus and persistent ulcerated swelling in the right-side cheek as the chief complaint.
Cheek ; Head ; Lymphoma ; Lymphoma, Non-Hodgkin* ; Mouth* ; Neck ; Oral Manifestations ; Trismus ; Ulcer

Dyke-Davidoff-Masson syndrome is a non-inherited rare condition that presents during childhood and is characterized by seizures, hemiplegia, mental retardation, cerebral hemiatrophy, calvarial thickening, and hyperpneumatization of the frontal sinuses. The present article highlights a case of a 12-year-old male child with additional clinical findings of café-au-late pigmentation and ocular lipodermoid. This is the first case report of Dyke-Davidoff-Masson syndrome to describe oral manifestations, such as unilateral delayed eruption of teeth, hypoplasia, and taurodontism, which could be unique and characteristic of this condition. Oral health care providers and physicians should be aware of these oral observations as dental referrals could warrant early dental prophylactic care and can be useful in diagnosing the possible time of injury and type of Dyke-Davidoff-Masson syndrome.
Child ; Dental Enamel Hypoplasia ; Frontal Sinus ; Hemiplegia ; Humans ; Intellectual Disability ; Male ; Open Bite ; Oral Health ; Oral Manifestations* ; Pigmentation ; Referral and Consultation ; Seizures ; Tooth

Osteonecrosis of the jaw (ONJ) is a well-known pathological condition in oncology derived from the use of bisphosphonates (BPs) and denosumab. Many molecular and immunological targets have been introduced for daily use in cancer treatment in recent years; consequently, new cases of ONJ have been reported in association with these drugs, especially if administered with BPs and denosumab. When the drugs are administered alone, ONJ is rarely seen. The objective of our study was to analyze the recent literature relative to the association of ONJ with these new drugs highlighting the pathogenic, clinical and therapeutic aspects. The close collaboration between maxillofacial surgeon, oncologist, dentist, and dental hygienist remains the most important aspect for the prevention, prompt recognition, and treatment of this pathology.
Angiogenesis Modulating Agents ; Cooperative Behavior ; Denosumab ; Dental Hygienists ; Dentists ; Diphosphonates ; Humans ; Immunomodulation ; Immunotherapy ; Jaw ; Oral and Maxillofacial Surgeons ; Oral Manifestations ; Osteonecrosis ; Pathology

Oral features include repeated occurrence of blisters, erosions, and scars, which lead to limited mouth opening, ankyloglossia, elimination of buccal vestibule, and increased risk of oral carcinoma. Routine dental care or even normal tooth brushing might cause bullae on the oral mucosa. Occasionally, the clinician will be called upon to treat patients with EB and should therefore be aware of specific treatment modifications. we present a reviews of the literature with a case providing adequate anesthetic and surgical care.]]>
Blister ; Cicatrix ; Dental Care ; Epidermolysis Bullosa ; Genetic Heterogeneity ; Humans ; Mouth ; Mouth Abnormalities ; Mouth Mucosa ; Oral Manifestations ; Phenotype ; Skin ; Tooth

oral cavity has been known to be less common one among oral manifestations of AIDS. The authors experienced a case of CMV infection on tongue of an AIDS patient. Thirty eight years old male developed a lesion on the dorsal surface and tip of tongue, manifesting superficial painful ulcer, and complained of the mouth discomfort. The histopathological features showed changes within the vascular endothelial cells : that is, extremely swollen cells with intracytoplasmic and intranuclear inclusions. Periodic acid-Schiff(PAS) and Gomori's methenamine silver(CMS) stains showed more prominent inclusions. The immunohistochemical stain using cytomegalovirus antibody(CMV Ab) showed strong positivity So it seems to us that was a good example of oral CMV infection in AIDS patient. Therefore we report one case of CMV stomatitis in AIDS patient.]]>
Coloring Agents ; Cytomegalovirus ; Endothelial Cells ; Humans ; Intranuclear Inclusion Bodies ; Male ; Methenamine ; Mouth ; Oral Manifestations ; Stomatitis ; Tongue ; Ulcer

Treating patients with severely worn dentition often requires comprehensive prosthetic treatments. Oral rehabilitation and long-term stability could be achieved by analyzing the cause of the wear and changing vertical dimension. The temporary restoration procedure is executed and patient's adaptation is evaluated by long-term observation when treatment is accompanied with increasing vertical dimension. In this case, 54 year-old male presented with worn dentition and esthetic dissatisfaction. In oral manifestations, severely worn dentition with attrition and erosion is diagnosed. To evaluate change of vertical dimension, interocclusal rest space, facial appearance, pronunciation, clinical crown length, distance from incisor edge to labial vestibule are evaluated. Consequently, 2.5 mm increase of vertical dimension that based on articulator incisal pin is determined. After 8 weeks stabilization period with temporary prostheses, definitive prostheses are fabricated. After 6 months follow up period, satisfactory outcomes were achieved both in functional and esthetic aspects through this procedure.
Crowns ; Dental Articulators ; Dentition* ; Follow-Up Studies ; Humans ; Incisor ; Male ; Mouth Rehabilitation* ; Oral Manifestations ; Prostheses and Implants ; Rehabilitation ; Tooth Wear ; Vertical Dimension*

Multiple myeloma is a clonal neoplastic proliferation of terminally differentiated B-lymphocytes involving the skeletal system in a multifocal fashion. Its oral manifestations are less common in the maxilla than in the mandible due to the lower amount of hemopoietic bone marrow in the maxilla. We report the case of a 50-year-old man who presented with a mass in the left maxillary alveolar region with tooth mobility. The mass had become enlarged after the teeth were extracted 15 days previously. Radiographs demonstrated multiple punched-out radiolucent lesions in the skull and pelvic region. Computed tomography images showed a soft tissue density mass in the left maxilla, eroding the floor and walls of the maxillary sinus. Although several analytical techniques were used to characterize the lesion, it was finally confirmed as multiple myeloma through immunohistochemistry.
B-Lymphocytes ; Bone Marrow ; Cytochrome P-450 CYP1A1 ; Humans ; Immunohistochemistry ; Mandible ; Maxilla ; Maxillary Sinus ; Middle Aged ; Multiple Myeloma* ; Oral Manifestations ; Pelvis ; Plasma Cells ; Plasmacytoma ; Skull ; Tooth ; Tooth Mobility

BACKGROUND: Skin disorders are common in human immunodeficiency virus (HIV)-infected patients in Korea. However, introduction of highly active antiretroviral therapy (HAART) has changed the skin manifestations of HIV infection. OBJECTIVE: We evaluated the frequency of skin disorders and their immune status using CD4+ T lymphocyte counts in HIV infected patients. METHODS: A retrospective study of 134 HIV-infected patients who visited in our clinic was carried out from September 2008 to July 2011. All subjects underwent complete physical examination to detect their skin disorders as well as necessary diagnostic procedures by consultation with the dermatologist. RESULTS: Tinea infection (including tinea corporis, tinea pedis and onychomycosis) was the most common skin disorder identified. Patients with a CD4+ T lymphocyte count of less than 200 cells/mm3 showed a significantly higher prevalence of syphilis, oral candidiasis and drug eruption compared with patients with a CD4+ T lymphocyte count of over 200 cells/mm3. CONCLUSION: Numerous skin disorders were demonstrated in HIV-infected patients. Among them, tinea infection was the most common skin manifestation in 134 HIV-infected patients. Moreover, Syphilis, oral candidiasis and drug eruption were associated with low CD4+ T lymphocyte counts. Further evaluation is necessary to confirm the trend towards changes in skin manifestations in HIV infected patients.
Antiretroviral Therapy, Highly Active ; Candidiasis, Oral ; Drug Eruptions ; HIV ; HIV Infections ; Humans ; Korea ; Lymphocyte Count* ; Lymphocytes* ; Physical Examination ; Prevalence ; Retrospective Studies ; Skin Manifestations ; Skin* ; Syphilis ; Tinea ; Tinea Pedis

PURPOSE: Methimazole is an anti-thyroid drug that can cause life-threatening neutropenia in rare situations. The aim of this case report is to describe a set of oral complications associated with methimazole-induced neutropenia and the healing of the gingiva after proper treatment. METHODS: A 31-year-old female patient hospitalized for systemic symptoms of sore throat and fever and showing extensive gingival necrosis with pain was referred to the Department of Periodontics from the Department of Endocrinology. Methimazole-induced neutropenia was diagnosed based on blood test results and her medical history. Methimazole was discontinued and a range of treatments was administered, including the injection of granulocyte colony stimulating factor. RESULTS: After systemic treatment, the gingiva began to heal as the neutrophil count increased. Approximately one year later, the gingiva had returned to a normal appearance. Twenty-one months after treatment, sequestra of the alveolar bone that had broken through the gingiva were removed. Periodic supportive periodontal treatment has been continued uneventfully. CONCLUSIONS: The oral manifestations of gingival necrosis and ulcerations, in combination with systemic symptoms such as fever and sore throat, are the critical signs presented in the early stages of drug-induced neutropenia. Therefore, dentists need to be aware of these oral complications in order to make an accurate diagnosis and to ensure that prompt medical intervention is provided.
Adult ; Colony-Stimulating Factors ; Dentists ; Diagnosis ; Endocrinology ; Female ; Fever ; Follow-Up Studies* ; Gingiva ; Granulocytes ; Hematologic Tests ; Humans ; Hyperthyroidism ; Methimazole ; Necrosis* ; Neutropenia* ; Neutrophils ; Oral Manifestations ; Periodontics ; Pharyngitis ; Ulcer